{"created":"2024-11-22T06:34:45.137501+00:00","id":2008129,"links":{},"metadata":{"_buckets":{"deposit":"cf8211f0-fb5d-44d7-9e34-32cb6348d856"},"_deposit":{"created_by":7,"id":"2008129","owners":[7],"pid":{"revision_id":0,"type":"depid","value":"2008129"},"status":"published"},"_oai":{"id":"oai:tokushima-u.repo.nii.ac.jp:02008129","sets":["1713853213384:1713853295607"]},"author_link":["426"],"control_number":"2008129","item_10001_alternative_title_1":{"attribute_name":"タイトル別表記","attribute_value_mlt":[{"subitem_alternative_title":"Ripasudil Promotes Neuroprotection","subitem_alternative_title_language":"en"}]},"item_10001_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2018-04","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"5","bibliographicPageEnd":"2089","bibliographicPageStart":"2080","bibliographicVolumeNumber":"59","bibliographic_titles":[{"bibliographic_title":"Investigative Ophthalmology & Visual Science","bibliographic_titleLang":"en"}]}]},"item_10001_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"PURPOSE. To assess if ripasudil has a neuroprotective effect using mice with excitatory amino acid carrier 1 (EAAC1) deletion (EAAC1 knockout [KO] mice), a mouse model of normal tension glaucoma.\nMETHODS. Topical administration (5 μL/day) of two different concentrations of ripasudil (0.4% and 2%) were applied to EAAC1 KO mice from 5 to 12 weeks old. Optical coherence tomography, multifocal electroretinograms, the measurement of intraocular pressure (IOP), and histopathology analyses were performed at 5, 8, and 12 weeks old. Retrograde labeling of retinal ganglion cells (RGCs), immunoblot, and immunohistochemical analyses of phosphorylated p38 mitogen-activated protein kinase (MAPK) in the retina were performed at 8 weeks old.\nRESULTS. Topical ripasudil ameliorated retinal degeneration and improved visual function in EAAC1 KO mice at both 8 and 12 weeks old. Ripasudil reduced IOP and strongly suppressed the phosphorylation of p38 MAPK that stimulates RGC death in EAAC1 KO mice.\nCONCLUSIONS. These results suggest that, in addition to IOP reduction, ripasudil prevents glaucomatous retinal degeneration by neuroprotection, which is achieved by suppressing cell-death signaling pathways.","subitem_description_language":"en","subitem_description_type":"Abstract"}]},"item_10001_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Silverchair","subitem_publisher_language":"en"},{"subitem_publisher":"The Association for Research in Vision and Ophthalmology","subitem_publisher_language":"en"}]},"item_10001_rights_15":{"attribute_name":"権利情報","attribute_value_mlt":[{"subitem_rights":"This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.","subitem_rights_language":"en"}]},"item_10001_source_id_9":{"attribute_name":"収録物ID","attribute_value_mlt":[{"subitem_source_identifier":"15525783","subitem_source_identifier_type":"ISSN"}]},"item_10001_version_type_20":{"attribute_name":"出版タイプ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_1715043197608":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"open access"}]},"item_1722929371688":{"attribute_name":"出版社版DOI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_language":"ja","subitem_relation_name_text":"10.1167/iovs.17-23276"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://doi.org/10.1167/iovs.17-23276","subitem_relation_type_select":"DOI"}}]},"item_1723180141928":{"attribute_name":"EID","attribute_value_mlt":[{"subitem_identifier_type":"URI","subitem_identifier_uri":"351504"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"赤岩, 慶","creatorNameLang":"ja"},{"creatorName":"アカイワ, ケイ","creatorNameLang":"ja-Kana"},{"creatorName":"Akaiwa, Kei","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"ナメカタ, カズヒコ","creatorNameLang":"ja"},{"creatorName":"ナメカタ, カズヒコ","creatorNameLang":"ja-Kana"},{"creatorName":"Namekata, Kazuhiko","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"アヅチ, ユリコ","creatorNameLang":"ja"},{"creatorName":"アヅチ, ユリコ","creatorNameLang":"ja-Kana"},{"creatorName":"Azuchi, Yuriko","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"サノ, ヒロキ","creatorNameLang":"ja"},{"creatorName":"サノ, ヒロキ","creatorNameLang":"ja-Kana"},{"creatorName":"Sano, Hiroki","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Guo, Xiaoli","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"キムラ, アツコ","creatorNameLang":"ja"},{"creatorName":"キムラ, アツコ","creatorNameLang":"ja-Kana"},{"creatorName":"Kimura, Atsuko","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"ハラダ, チカコ","creatorNameLang":"ja"},{"creatorName":"ハラダ, チカコ","creatorNameLang":"ja-Kana"},{"creatorName":"Harada, Chikako","creatorNameLang":"en"}]},{"creatorAffiliations":[{"affiliationNameIdentifiers":[{"affiliationNameIdentifier":"","affiliationNameIdentifierScheme":"ISNI","affiliationNameIdentifierURI":"http://www.isni.org/isni/"}],"affiliationNames":[{"affiliationName":"","affiliationNameLang":"ja"}]}],"creatorNames":[{"creatorName":"三田村, 佳典","creatorNameLang":"ja"},{"creatorName":"ミタムラ, ヨシノリ","creatorNameLang":"ja-Kana"},{"creatorName":"Mitamura, Yoshinori","creatorNameLang":"en"}],"familyNames":[{"familyName":"三田村","familyNameLang":"ja"},{"familyName":"ミタムラ","familyNameLang":"ja-Kana"},{"familyName":"Mitamura","familyNameLang":"en"}],"givenNames":[{"givenName":"佳典","givenNameLang":"ja"},{"givenName":"ヨシノリ","givenNameLang":"ja-Kana"},{"givenName":"Yoshinori","givenNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"426","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"207501/profile-ja.html","nameIdentifierScheme":"徳島大学 教育研究者総覧","nameIdentifierURI":"http://pub2.db.tokushima-u.ac.jp/ERD/person/207501/profile-ja.html"},{"nameIdentifier":"30287536","nameIdentifierScheme":"e-Rad","nameIdentifierURI":"https://nrid.nii.ac.jp/ja/search/?qm=30287536"}]},{"creatorNames":[{"creatorName":"ハラダ, タカユキ","creatorNameLang":"ja"},{"creatorName":"ハラダ, タカユキ","creatorNameLang":"ja-Kana"},{"creatorName":"Harada, Takayuki","creatorNameLang":"en"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_access","date":[{"dateType":"Available","dateValue":"2021-02-10"}],"displaytype":"detail","filename":"iovs_59_5_2080.pdf","filesize":[{"value":"1.31 MB"}],"format":"application/pdf","licensetype":"license_5","mimetype":"application/pdf","url":{"objectType":"fulltext","url":"https://tokushima-u.repo.nii.ac.jp/record/2008129/files/iovs_59_5_2080.pdf"},"version_id":"f314b1ce-7641-476d-bff7-20c914588ed0"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"ripasudil","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"glaucoma","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"neuroprotection","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"intraocular pressure","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"p38","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Topical Ripasudil Suppresses Retinal Ganglion Cell Death in a Mouse Model of Normal Tension Glaucoma","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Topical Ripasudil Suppresses Retinal Ganglion Cell Death in a Mouse Model of Normal Tension Glaucoma","subitem_title_language":"en"}]},"item_type_id":"40001","owner":"7","path":["1713853295607"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2021-02-10"},"publish_date":"2021-02-10","publish_status":"0","recid":"2008129","relation_version_is_last":true,"title":["Topical Ripasudil Suppresses Retinal Ganglion Cell Death in a Mouse Model of Normal Tension Glaucoma"],"weko_creator_id":"7","weko_shared_id":-1},"updated":"2025-01-29T07:31:17.940044+00:00"}