{"created":"2024-11-22T06:37:40.208386+00:00","id":2008159,"links":{},"metadata":{"_buckets":{"deposit":"c43b09ba-6b2f-4945-b485-f9f05289b015"},"_deposit":{"created_by":7,"id":"2008159","owners":[7],"pid":{"revision_id":0,"type":"depid","value":"2008159"},"status":"published"},"_oai":{"id":"oai:tokushima-u.repo.nii.ac.jp:02008159","sets":["1713853213384:1713853295607"]},"author_link":["1594","246"],"control_number":"2008159","item_10001_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2019-04-23","bibliographicIssueDateType":"Issued"},"bibliographicPageStart":"1844","bibliographicVolumeNumber":"10","bibliographic_titles":[{"bibliographic_title":"Nature Communications","bibliographic_titleLang":"en"}]}]},"item_10001_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Lentiviruses have evolved to acquire an auxiliary protein Vpx to counteract the intrinsic host restriction factor SAMHD1. Although Vpx is phosphorylated, it remains unclear whether such phosphorylation indeed regulates its activity toward SAMHD1. Here we identify the PIM family of serine/threonine protein kinases as the factors responsible for the phosphorylation of Vpx and the promotion of Vpx-mediated SAMHD1 counteraction. Integrated proteomics and subsequent functional analysis reveal that PIM family kinases, PIM1 and PIM3, phosphorylate HIV-2 Vpx at Ser13 and stabilize the interaction of Vpx with SAMHD1 thereby promoting ubiquitin-mediated proteolysis of SAMHD1. Inhibition of the PIM kinases promotes the antiviral activity of SAMHD1, ultimately reducing viral replication. Our results highlight a new mode of virus–host cell interaction in which host PIM kinases facilitate promotion of viral infectivity by counteracting the host antiviral system, and suggest a novel therapeutic strategy involving restoration of SAMHD1-mediated antiviral response.","subitem_description_language":"en","subitem_description_type":"Abstract"}]},"item_10001_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Springer Nature","subitem_publisher_language":"en"}]},"item_10001_rights_15":{"attribute_name":"権利情報","attribute_value_mlt":[{"subitem_rights":"This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/","subitem_rights_language":"en"}]},"item_10001_source_id_9":{"attribute_name":"収録物ID","attribute_value_mlt":[{"subitem_source_identifier":"20411723","subitem_source_identifier_type":"ISSN"},{"subitem_source_identifier":"AA12645905","subitem_source_identifier_type":"NCID"}]},"item_10001_version_type_20":{"attribute_name":"出版タイプ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_1715043197608":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"open access"}]},"item_1722929371688":{"attribute_name":"出版社版DOI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_language":"ja","subitem_relation_name_text":"10.1038/s41467-019-09867-7"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://doi.org/10.1038/s41467-019-09867-7","subitem_relation_type_select":"DOI"}}]},"item_1723180141928":{"attribute_name":"EID","attribute_value_mlt":[{"subitem_identifier_type":"URI","subitem_identifier_uri":"354803"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"ミヤカワ, ケイ","creatorNameLang":"ja"},{"creatorName":"ミヤカワ, ケイ","creatorNameLang":"ja-Kana"},{"creatorName":"Miyakawa, Kei","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"マツナガ, サトコ","creatorNameLang":"ja"},{"creatorName":"マツナガ, サトコ","creatorNameLang":"ja-Kana"},{"creatorName":"Matsunaga, Satoko","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"ヨコヤマ, マサル","creatorNameLang":"ja"},{"creatorName":"ヨコヤマ, マサル","creatorNameLang":"ja-Kana"},{"creatorName":"Yokoyama, Masaru","creatorNameLang":"en"}]},{"creatorAffiliations":[{"affiliationNameIdentifiers":[{"affiliationNameIdentifier":"","affiliationNameIdentifierScheme":"ISNI","affiliationNameIdentifierURI":"http://www.isni.org/isni/"}],"affiliationNames":[{"affiliationName":"","affiliationNameLang":"ja"}]}],"creatorNames":[{"creatorName":"野間口, 雅子","creatorNameLang":"ja"},{"creatorName":"ノマグチ, マサコ","creatorNameLang":"ja-Kana"},{"creatorName":"Nomaguchi, Masako","creatorNameLang":"en"}],"familyNames":[{"familyName":"野間口","familyNameLang":"ja"},{"familyName":"ノマグチ","familyNameLang":"ja-Kana"},{"familyName":"Nomaguchi","familyNameLang":"en"}],"givenNames":[{"givenName":"雅子","givenNameLang":"ja"},{"givenName":"マサコ","givenNameLang":"ja-Kana"},{"givenName":"Masako","givenNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"246","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"153171/profile-ja.html","nameIdentifierScheme":"徳島大学 教育研究者総覧","nameIdentifierURI":"http://pub2.db.tokushima-u.ac.jp/ERD/person/153171/profile-ja.html"},{"nameIdentifier":"80452647","nameIdentifierScheme":"e-Rad","nameIdentifierURI":"https://nrid.nii.ac.jp/ja/search/?qm=80452647"}]},{"creatorNames":[{"creatorName":"キムラ, ヤヨイ","creatorNameLang":"ja"},{"creatorName":"キムラ, ヤヨイ","creatorNameLang":"ja-Kana"},{"creatorName":"Kimura, Yayoi","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"ニシ, マユコ","creatorNameLang":"ja"},{"creatorName":"ニシ, マユコ","creatorNameLang":"ja-Kana"},{"creatorName":"Nishi, Mayuko","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"キムラ, ヒロカズ","creatorNameLang":"ja"},{"creatorName":"キムラ, ヒロカズ","creatorNameLang":"ja-Kana"},{"creatorName":"Kimura, Hirokazu","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"サトウ, ヒロノリ","creatorNameLang":"ja"},{"creatorName":"サトウ, ヒロノリ","creatorNameLang":"ja-Kana"},{"creatorName":"Sato, Hironori","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"ヒラノ, ヒサシ","creatorNameLang":"ja"},{"creatorName":"ヒラノ, ヒサシ","creatorNameLang":"ja-Kana"},{"creatorName":"Hirano, Hisashi","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"タムラ, トモヒコ","creatorNameLang":"ja"},{"creatorName":"タムラ, トモヒコ","creatorNameLang":"ja-Kana"},{"creatorName":"Tamura, Tomohiko","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"アカリ, ヒロフミ","creatorNameLang":"ja"},{"creatorName":"アカリ, ヒロフミ","creatorNameLang":"ja-Kana"},{"creatorName":"Akari, Hirofumi","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"ミウラ, トモユキ","creatorNameLang":"ja"},{"creatorName":"ミウラ, トモユキ","creatorNameLang":"ja-Kana"},{"creatorName":"Miura, Tomoyuki","creatorNameLang":"en"}]},{"creatorAffiliations":[{"affiliationNameIdentifiers":[{"affiliationNameIdentifier":"","affiliationNameIdentifierScheme":"ISNI","affiliationNameIdentifierURI":"http://www.isni.org/isni/"}],"affiliationNames":[{"affiliationName":"","affiliationNameLang":"ja"}]}],"creatorNames":[{"creatorName":"足立, 昭夫","creatorNameLang":"ja"},{"creatorName":"アダチ, アキオ","creatorNameLang":"ja-Kana"},{"creatorName":"Adachi, Akio","creatorNameLang":"en"}],"familyNames":[{"familyName":"足立","familyNameLang":"ja"},{"familyName":"アダチ","familyNameLang":"ja-Kana"},{"familyName":"Adachi","familyNameLang":"en"}],"givenNames":[{"givenName":"昭夫","givenNameLang":"ja"},{"givenName":"アキオ","givenNameLang":"ja-Kana"},{"givenName":"Akio","givenNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"1594","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"60165/profile-ja.html","nameIdentifierScheme":"徳島大学 教育研究者総覧","nameIdentifierURI":"http://pub2.db.tokushima-u.ac.jp/ERD/person/60165/profile-ja.html"},{"nameIdentifier":"90127043","nameIdentifierScheme":"e-Rad","nameIdentifierURI":"https://nrid.nii.ac.jp/ja/search/?qm=90127043"}]},{"creatorNames":[{"creatorName":"サワサキ, タツヤ","creatorNameLang":"ja"},{"creatorName":"サワサキ, タツヤ","creatorNameLang":"ja-Kana"},{"creatorName":"Sawasaki, Tatsuya","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"ヤマモト, ナオキ","creatorNameLang":"ja"},{"creatorName":"ヤマモト, ナオキ","creatorNameLang":"ja-Kana"},{"creatorName":"Yamamoto, Naoki","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"リョウ, アキヒデ","creatorNameLang":"ja"},{"creatorName":"リョウ, アキヒデ","creatorNameLang":"ja-Kana"},{"creatorName":"Ryo, Akihide","creatorNameLang":"en"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_access","date":[{"dateType":"Available","dateValue":"2020-12-25"}],"displaytype":"detail","filename":"ncomms_10_1844.pdf","filesize":[{"value":"1.88 MB"}],"format":"application/pdf","licensetype":"license_0","mimetype":"application/pdf","url":{"objectType":"fulltext","url":"https://tokushima-u.repo.nii.ac.jp/record/2008159/files/ncomms_10_1844.pdf"},"version_id":"37e76680-0d94-483b-a2b0-1df960a37a23"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"PIM kinases facilitate lentiviral evasion from SAMHD1 restriction via Vpx phosphorylation","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"PIM kinases facilitate lentiviral evasion from SAMHD1 restriction via Vpx phosphorylation","subitem_title_language":"en"}]},"item_type_id":"40001","owner":"7","path":["1713853295607"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2020-12-25"},"publish_date":"2020-12-25","publish_status":"0","recid":"2008159","relation_version_is_last":true,"title":["PIM kinases facilitate lentiviral evasion from SAMHD1 restriction via Vpx phosphorylation"],"weko_creator_id":"7","weko_shared_id":-1},"updated":"2025-01-29T05:44:22.160547+00:00"}