{"created":"2024-11-22T06:43:37.545284+00:00","id":2008228,"links":{},"metadata":{"_buckets":{"deposit":"52eed896-56de-4843-8750-03bee0ed2674"},"_deposit":{"created_by":7,"id":"2008228","owners":[7],"pid":{"revision_id":0,"type":"depid","value":"2008228"},"status":"published"},"_oai":{"id":"oai:tokushima-u.repo.nii.ac.jp:02008228","sets":["1713853213384:1713853295607"]},"author_link":["1648","1264"],"item_10001_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2020-09-23","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"2","bibliographicPageEnd":"268","bibliographicPageStart":"262","bibliographicVolumeNumber":"32","bibliographic_titles":[{"bibliographic_title":"Endocrine Pathology","bibliographic_titleLang":"en"}]}]},"item_10001_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Craniopharyngioma (CP) is mainly classified into two pathological subtypes: adamantinomatous (ACP) and papillary (PCP). CTNNB1 (β-catenin) mutations are detected in ACPs, and the BRAF V600E mutation is detected in PCPs. However, genetic analysis is not always possible in general medical practice. In this study, we investigated whether immunohistochemistry could replace genetic analysis as an aid in subtype diagnosis. Here, 38 CP patients who had undergone their first tumor resection were included. Among the 38 cases, 22 were morphologically diagnosed as ACP, 10 cases were diagnosed as PCP, and six cases were diagnosed as undetermined CP that were morphologically difficult to classify as either ACP or PCP. Results of immunohistochemistry and genetic analysis and clinical features were compared. Based on the immunohistochemistry, 26 (22 ACPs and four undetermined CPs) showed nuclear β-catenin expression, 11 (nine PCPs and two undetermined CPs) exhibited positive BRAF V600E immunostaining and one PCP showed membranous β-catenin expression and negative for BRAF V600E immunostaining. Among the 26 nuclear β-catenin expression cases, 11 had CTNNB1 mutations; however, 15 cases had mutations of neither CTNNB1 nor BRAF V600E. All 11 BRAF V600E immunopositive cases had BRAF V600E mutations. When comparing clinical features between, pediatric patients and those with tumor calcification and less solid components on MRI more commonly had nuclear β-catenin expression tumors than BRAF V600E immunopositive tumors, reflecting the differences in clinical features between ACP and PCP. Accordingly, immunohistochemistry can replace genetic analysis as an aid to determine the subtype diagnosis of CP in general medical practice.","subitem_description_language":"en","subitem_description_type":"Abstract"}]},"item_10001_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Springer Science+Business Media","subitem_publisher_language":"en"},{"subitem_publisher":"Springer Nature","subitem_publisher_language":"en"}]},"item_10001_source_id_9":{"attribute_name":"収録物ID","attribute_value_mlt":[{"subitem_source_identifier":"15590097","subitem_source_identifier_type":"ISSN"},{"subitem_source_identifier":"10463976","subitem_source_identifier_type":"ISSN"},{"subitem_source_identifier":"AA10803175","subitem_source_identifier_type":"NCID"}]},"item_10001_version_type_20":{"attribute_name":"出版タイプ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_1715043197608":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"open access"}]},"item_1718868208704":{"attribute_name":"備考","attribute_value_mlt":[{"subitem_textarea_language":"ja","subitem_textarea_value":"This is a post-peer-review, pre-copyedit version of an article published in Endocrine Pathology. The final authenticated version is available online at: http://dx.doi.org/10.1007/s12022-020-09644-z."}]},"item_1722929371688":{"attribute_name":"出版社版DOI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_language":"ja","subitem_relation_name_text":"10.1007/s12022-020-09644-z"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://doi.org/10.1007/s12022-020-09644-z","subitem_relation_type_select":"DOI"}}]},"item_1723180141928":{"attribute_name":"EID","attribute_value_mlt":[{"subitem_identifier_type":"URI","subitem_identifier_uri":"371551"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"フクハラ, ノリアキ","creatorNameLang":"ja"},{"creatorName":"フクハラ, ノリアキ","creatorNameLang":"ja-Kana"},{"creatorName":"Fukuhara, Noriaki","creatorNameLang":"en"}]},{"creatorAffiliations":[{"affiliationNameIdentifiers":[{"affiliationNameIdentifier":"","affiliationNameIdentifierScheme":"ISNI","affiliationNameIdentifierURI":"http://www.isni.org/isni/"}],"affiliationNames":[{"affiliationName":"","affiliationNameLang":"ja"}]}],"creatorNames":[{"creatorName":"岩田, 武男","creatorNameLang":"ja"},{"creatorName":"イワタ, タケオ","creatorNameLang":"ja-Kana"},{"creatorName":"Iwata, Takeo","creatorNameLang":"en"}],"familyNames":[{"familyName":"岩田","familyNameLang":"ja"},{"familyName":"イワタ","familyNameLang":"ja-Kana"},{"familyName":"Iwata","familyNameLang":"en"}],"givenNames":[{"givenName":"武男","givenNameLang":"ja"},{"givenName":"タケオ","givenNameLang":"ja-Kana"},{"givenName":"Takeo","givenNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"1264","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"10350399","nameIdentifierScheme":"e-Rad","nameIdentifierURI":"https://nrid.nii.ac.jp/ja/search/?qm=10350399"}]},{"creatorNames":[{"creatorName":"イノシタ, ナオコ","creatorNameLang":"ja"},{"creatorName":"イノシタ, ナオコ","creatorNameLang":"ja-Kana"},{"creatorName":"Inoshita, Naoko","creatorNameLang":"en"}]},{"creatorAffiliations":[{"affiliationNameIdentifiers":[{"affiliationNameIdentifier":"","affiliationNameIdentifierScheme":"ISNI","affiliationNameIdentifierURI":"http://www.isni.org/isni/"}],"affiliationNames":[{"affiliationName":"","affiliationNameLang":"ja"}]}],"creatorNames":[{"creatorName":"吉本, 勝彦","creatorNameLang":"ja"},{"creatorName":"ヨシモト, カツヒコ","creatorNameLang":"ja-Kana"},{"creatorName":"Yoshimoto, Katsuhiko","creatorNameLang":"en"}],"familyNames":[{"familyName":"吉本","familyNameLang":"ja"},{"familyName":"ヨシモト","familyNameLang":"ja-Kana"},{"familyName":"Yoshimoto","familyNameLang":"en"}],"givenNames":[{"givenName":"勝彦","givenNameLang":"ja"},{"givenName":"カツヒコ","givenNameLang":"ja-Kana"},{"givenName":"Katsuhiko","givenNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"1648","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"60308/profile-ja.html","nameIdentifierScheme":"徳島大学 教育研究者総覧","nameIdentifierURI":"http://pub2.db.tokushima-u.ac.jp/ERD/person/60308/profile-ja.html"},{"nameIdentifier":"90201863","nameIdentifierScheme":"e-Rad","nameIdentifierURI":"https://nrid.nii.ac.jp/ja/search/?qm=90201863"}]},{"creatorNames":[{"creatorName":"キタガワ, マサノブ","creatorNameLang":"ja"},{"creatorName":"キタガワ, マサノブ","creatorNameLang":"ja-Kana"},{"creatorName":"Kitagawa, Masanobu","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"フクハラ, ヒロカズ","creatorNameLang":"ja"},{"creatorName":"フクハラ, ヒロカズ","creatorNameLang":"ja-Kana"},{"creatorName":"Fukuhara, Hirokazu","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"タツシマ, ケイタ","creatorNameLang":"ja"},{"creatorName":"タツシマ, ケイタ","creatorNameLang":"ja-Kana"},{"creatorName":"Tatsushima, Keita","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"ヤマグチ オカダ, ミツオ","creatorNameLang":"ja"},{"creatorName":"ヤマグチ オカダ, ミツオ","creatorNameLang":"ja-Kana"},{"creatorName":"Yamaguchi-Okada, Mitsuo","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"タケシタ, アキラ","creatorNameLang":"ja"},{"creatorName":"タケシタ, アキラ","creatorNameLang":"ja-Kana"},{"creatorName":"Takeshita, Akira","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"イトウ, ジュンコ","creatorNameLang":"ja"},{"creatorName":"イトウ, ジュンコ","creatorNameLang":"ja-Kana"},{"creatorName":"Ito, Junko","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"タケウチ, ヤスヒロ","creatorNameLang":"ja"},{"creatorName":"タケウチ, ヤスヒロ","creatorNameLang":"ja-Kana"},{"creatorName":"Takeuchi, Yasuhiro","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"山田, 正三","creatorNameLang":"ja"},{"creatorName":"ヤマダ, ショウゾウ","creatorNameLang":"ja-Kana"},{"creatorName":"Yamada, Shozo","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"ニシオカ, ヒロシ","creatorNameLang":"ja"},{"creatorName":"ニシオカ, ヒロシ","creatorNameLang":"ja-Kana"},{"creatorName":"Nishioka, Hiroshi","creatorNameLang":"en"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_access","date":[{"dateType":"Available","dateValue":"2021-09-23"}],"displaytype":"detail","filename":"ep_32_2_262.pdf","filesize":[{"value":"545 KB"}],"format":"application/pdf","mimetype":"application/pdf","url":{"objectType":"fulltext","url":"https://tokushima-u.repo.nii.ac.jp/record/2008228/files/ep_32_2_262.pdf"},"version_id":"1af386e5-9d5b-4ccb-985b-49b2d7864992"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"Craniopharyngioma","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"CTNNB1","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"β-Catenin","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"BRAF V600E","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Immunohistochemistry or Molecular Analysis : Which Method Is Better for Subtyping Craniopharyngioma?","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Immunohistochemistry or Molecular Analysis : Which Method Is Better for Subtyping Craniopharyngioma?","subitem_title_language":"en"}]},"item_type_id":"40001","owner":"7","path":["1713853295607"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2020-09-29"},"publish_date":"2020-09-29","publish_status":"0","recid":"2008228","relation_version_is_last":true,"title":["Immunohistochemistry or Molecular Analysis : Which Method Is Better for Subtyping Craniopharyngioma?"],"weko_creator_id":"7","weko_shared_id":-1},"updated":"2025-01-29T01:09:48.848108+00:00"}