{"created":"2024-11-22T06:47:24.492354+00:00","id":2008265,"links":{},"metadata":{"_buckets":{"deposit":"5a0b5b36-ccf9-4dad-a8ad-b55d22075b58"},"_deposit":{"created_by":7,"id":"2008265","owners":[7],"pid":{"revision_id":0,"type":"depid","value":"2008265"},"status":"published"},"_oai":{"id":"oai:tokushima-u.repo.nii.ac.jp:02008265","sets":["1713853213384:1713853296295:1716267876683:1716268551628"]},"author_link":["1012","1559","615","1214","831","834","176","612","1540","1548"],"item_10001_alternative_title_1":{"attribute_name":"タイトル別表記","attribute_value_mlt":[{"subitem_alternative_title":"甲状腺未分化癌同所移植SCIDマウスモデルへのパクリタキセルとレンバチニブの有効性に対する小動物用FDG-PET/CTを用いた非侵襲的モニタリング","subitem_alternative_title_language":"ja"},{"subitem_alternative_title":"MONITORING ANAPLASTIC THYROID CANCER MODELS BY PET/CT","subitem_alternative_title_language":"en"}]},"item_10001_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2020-08-07","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"4","bibliographicPageEnd":"1716","bibliographicPageStart":"1709","bibliographicVolumeNumber":"44","bibliographic_titles":[{"bibliographic_title":"Oncology Reports","bibliographic_titleLang":"en"}]}]},"item_10001_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Anaplastic thyroid carcinoma (ATC) is a rare type of thyroid carcinoma with a poor prognosis. Thus, suitable preclinical tumor models are required for the development of new ATC therapies. In the present study, orthotopic tumor xenograft models were established using ATC cell lines and SCID mice, and tumor invasion and the effects of anticancer drugs were evaluated using positron emission tomography/computed tomography (PET/CT) to repeatedly and non-invasively monitor these models. Three ATC cell lines (8305c, 8505c, and ACT-1) were used. Their sensitivities to two anticancer drugs (paclitaxel and lenvatinib) were investigated. The 8505c cell line was orthotopically implanted into SCID mice, which were then divided into three groups: no chemotherapy, paclitaxel (5 mg/kg, administered intraperitoneally, every week), and lenvatinib (5 mg/kg, oral route, every day) groups. PET/CT was performed and tumor growth and the effects of anticancer drugs based on tumor volume and fludeoxyglucose (FDG) uptake were evaluated. 8505c cells exhibited the highest sensitivity to the anticancer drugs. In mice implanted with 8505c cells, continuous increases in FDG uptake associated with tumor growth were detected on PET/CT in the group that received no chemotherapy. The tumor volume and FDG uptake increased by 91.5- and 2.4-fold, respectively, within 2 weeks. The increase observed in tumor volume was 26.9- and 12.2-fold in the paclitaxel and lenvatinib groups, respectively, within 2 weeks. Furthermore, the increase in FDG uptake was 1.8-fold and 1.6-fold in the paclitaxel and lenvatinib groups, respectively, within 2 weeks. In our orthotopic SCID mouse model, tumor growth and the effects of anticancer drugs were repeatedly and non-invasively monitored using PET/CT. The present method is useful for the development of new ATC treatments.","subitem_description_language":"en","subitem_description_type":"Abstract"}]},"item_10001_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Spandidos Publications","subitem_publisher_language":"en"}]},"item_10001_source_id_9":{"attribute_name":"収録物ID","attribute_value_mlt":[{"subitem_source_identifier":"1021335X","subitem_source_identifier_type":"ISSN"},{"subitem_source_identifier":"17912431","subitem_source_identifier_type":"ISSN"},{"subitem_source_identifier":"AA11016405","subitem_source_identifier_type":"NCID"}]},"item_10001_version_type_20":{"attribute_name":"出版タイプ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_be7fb7dd8ff6fe43","subitem_version_type":"NA"}]},"item_1714461018643":{"attribute_name":"報告番号","attribute_value_mlt":[{"subitem_dissertationnumber":"甲第3461号"}]},"item_1714461102074":{"attribute_name":"学位名","attribute_value_mlt":[{"subitem_degreename":"博士（医学）","subitem_degreename_language":"ja"}]},"item_1714461118377":{"attribute_name":"学位授与年月日","attribute_value_mlt":[{"subitem_dategranted":"2020-09-24"}]},"item_1714461137393":{"attribute_name":"学位授与機関","attribute_value_mlt":[{"subitem_degreegrantor":[{"subitem_degreegrantor_language":"ja","subitem_degreegrantor_name":"徳島大学"}]}]},"item_1715043197608":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"open access"}]},"item_1718868208704":{"attribute_name":"備考","attribute_value_mlt":[{"subitem_textarea_language":"ja","subitem_textarea_value":"内容要旨・審査要旨・論文本文の公開\n本論文は，著者Mariko Aoyamaの学位論文として提出され，学位審査・授与の対象となっている。\n学位授与者所属 : 徳島大学大学院医科学教育部（医学専攻）"}]},"item_1718868303842":{"attribute_name":"学位記番号","attribute_value_mlt":[{"subitem_text_language":"ja","subitem_text_value":"甲医第1468号"}]},"item_1722929371688":{"attribute_name":"出版社版DOI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_language":"ja","subitem_relation_name_text":"10.3892/or.2020.7720"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://doi.org/10.3892/or.2020.7720","subitem_relation_type_select":"DOI"}}]},"item_1723180141928":{"attribute_name":"EID","attribute_value_mlt":[{"subitem_identifier_type":"URI","subitem_identifier_uri":"373106"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorAffiliations":[{"affiliationNameIdentifiers":[{"affiliationNameIdentifier":"","affiliationNameIdentifierScheme":"ISNI","affiliationNameIdentifierURI":"http://www.isni.org/isni/"}],"affiliationNames":[{"affiliationName":"","affiliationNameLang":"ja"}]}],"creatorNames":[{"creatorName":"(青山)三崎, 万理子","creatorNameLang":"ja"},{"creatorName":"(アオヤマ)ミサキ, マリコ","creatorNameLang":"ja-Kana"},{"creatorName":"Aoyama-Misaki, Mariko","creatorNameLang":"en"}],"familyNames":[{"familyName":"(青山)三崎","familyNameLang":"ja"},{"familyName":"(アオヤマ)ミサキ","familyNameLang":"ja-Kana"},{"familyName":"Aoyama-Misaki","familyNameLang":"en"}],"givenNames":[{"givenName":"万理子","givenNameLang":"ja"},{"givenName":"マリコ","givenNameLang":"ja-Kana"},{"givenName":"Mariko","givenNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"1012","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"364614/profile-ja.html","nameIdentifierScheme":"徳島大学 教育研究者総覧","nameIdentifierURI":"http://pub2.db.tokushima-u.ac.jp/ERD/person/364614/profile-ja.html"},{"nameIdentifier":"60598639","nameIdentifierScheme":"e-Rad","nameIdentifierURI":"https://nrid.nii.ac.jp/ja/search/?qm=60598639"}]},{"creatorAffiliations":[{"affiliationNameIdentifiers":[{"affiliationNameIdentifier":"","affiliationNameIdentifierScheme":"ISNI","affiliationNameIdentifierURI":"http://www.isni.org/isni/"}],"affiliationNames":[{"affiliationName":"","affiliationNameLang":"ja"}]}],"creatorNames":[{"creatorName":"滝沢, 宏光","creatorNameLang":"ja"},{"creatorName":"タキザワ, ヒロミツ","creatorNameLang":"ja-Kana"},{"creatorName":"Takizawa, Hiromitsu","creatorNameLang":"en"}],"familyNames":[{"familyName":"滝沢","familyNameLang":"ja"},{"familyName":"タキザワ","familyNameLang":"ja-Kana"},{"familyName":"Takizawa","familyNameLang":"en"}],"givenNames":[{"givenName":"宏光","givenNameLang":"ja"},{"givenName":"ヒロミツ","givenNameLang":"ja-Kana"},{"givenName":"Hiromitsu","givenNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"1214","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"73178/profile-ja.html","nameIdentifierScheme":"徳島大学 教育研究者総覧","nameIdentifierURI":"http://pub2.db.tokushima-u.ac.jp/ERD/person/73178/profile-ja.html"},{"nameIdentifier":"90332816","nameIdentifierScheme":"e-Rad","nameIdentifierURI":"https://nrid.nii.ac.jp/ja/search/?qm=90332816"}]},{"creatorAffiliations":[{"affiliationNameIdentifiers":[{"affiliationNameIdentifier":"","affiliationNameIdentifierScheme":"ISNI","affiliationNameIdentifierURI":"http://www.isni.org/isni/"}],"affiliationNames":[{"affiliationName":"","affiliationNameLang":"ja"}]}],"creatorNames":[{"creatorName":"大谷, 環樹","creatorNameLang":"ja"},{"creatorName":"オオタニ, タマキ","creatorNameLang":"ja-Kana"},{"creatorName":"Otani, Tamaki","creatorNameLang":"en"}],"familyNames":[{"familyName":"大谷","familyNameLang":"ja"},{"familyName":"オオタニ","familyNameLang":"ja-Kana"},{"familyName":"Otani","familyNameLang":"en"}],"givenNames":[{"givenName":"環樹","givenNameLang":"ja"},{"givenName":"タマキ","givenNameLang":"ja-Kana"},{"givenName":"Tamaki","givenNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"612","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"261370/profile-ja.html","nameIdentifierScheme":"徳島大学 教育研究者総覧","nameIdentifierURI":"http://pub2.db.tokushima-u.ac.jp/ERD/person/261370/profile-ja.html"},{"nameIdentifier":"40709557","nameIdentifierScheme":"e-Rad","nameIdentifierURI":"https://nrid.nii.ac.jp/ja/search/?qm=40709557"}]},{"creatorAffiliations":[{"affiliationNameIdentifiers":[{"affiliationNameIdentifier":"","affiliationNameIdentifierScheme":"ISNI","affiliationNameIdentifierURI":"http://www.isni.org/isni/"}],"affiliationNames":[{"affiliationName":"","affiliationNameLang":"ja"}]}],"creatorNames":[{"creatorName":"井上, 聖也","creatorNameLang":"ja"},{"creatorName":"イノウエ, セイヤ","creatorNameLang":"ja-Kana"},{"creatorName":"Inoue, Seiya","creatorNameLang":"en"}],"familyNames":[{"familyName":"井上","familyNameLang":"ja"},{"familyName":"イノウエ","familyNameLang":"ja-Kana"},{"familyName":"Inoue","familyNameLang":"en"}],"givenNames":[{"givenName":"聖也","givenNameLang":"ja"},{"givenName":"セイヤ","givenNameLang":"ja-Kana"},{"givenName":"Seiya","givenNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"831","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"310675/profile-ja.html","nameIdentifierScheme":"徳島大学 教育研究者総覧","nameIdentifierURI":"http://pub2.db.tokushima-u.ac.jp/ERD/person/310675/profile-ja.html"}]},{"creatorAffiliations":[{"affiliationNameIdentifiers":[{"affiliationNameIdentifier":"","affiliationNameIdentifierScheme":"ISNI","affiliationNameIdentifierURI":"http://www.isni.org/isni/"}],"affiliationNames":[{"affiliationName":"","affiliationNameLang":"ja"}]}],"creatorNames":[{"creatorName":"河北, 直也","creatorNameLang":"ja"},{"creatorName":"カワキタ, ナオヤ","creatorNameLang":"ja-Kana"},{"creatorName":"Kawakita, Naoya","creatorNameLang":"en"}],"familyNames":[{"familyName":"河北","familyNameLang":"ja"},{"familyName":"カワキタ","familyNameLang":"ja-Kana"},{"familyName":"Kawakita","familyNameLang":"en"}],"givenNames":[{"givenName":"直也","givenNameLang":"ja"},{"givenName":"ナオヤ","givenNameLang":"ja-Kana"},{"givenName":"Naoya","givenNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"834","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"310688/profile-ja.html","nameIdentifierScheme":"徳島大学 教育研究者総覧","nameIdentifierURI":"http://pub2.db.tokushima-u.ac.jp/ERD/person/310688/profile-ja.html"}]},{"creatorAffiliations":[{"affiliationNameIdentifiers":[{"affiliationNameIdentifier":"","affiliationNameIdentifierScheme":"ISNI","affiliationNameIdentifierURI":"http://www.isni.org/isni/"}],"affiliationNames":[{"affiliationName":"","affiliationNameLang":"ja"}]}],"creatorNames":[{"creatorName":"坪井, 光弘","creatorNameLang":"ja"},{"creatorName":"ツボイ, ミツヒロ","creatorNameLang":"ja-Kana"},{"creatorName":"Tsuboi, Mitsuhiro","creatorNameLang":"en"}],"familyNames":[{"familyName":"坪井","familyNameLang":"ja"},{"familyName":"ツボイ","familyNameLang":"ja-Kana"},{"familyName":"Tsuboi","familyNameLang":"en"}],"givenNames":[{"givenName":"光弘","givenNameLang":"ja"},{"givenName":"ミツヒロ","givenNameLang":"ja-Kana"},{"givenName":"Mitsuhiro","givenNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"615","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"10711872","nameIdentifierScheme":"e-Rad","nameIdentifierURI":"https://nrid.nii.ac.jp/ja/search/?qm=10711872"}]},{"creatorAffiliations":[{"affiliationNameIdentifiers":[{"affiliationNameIdentifier":"","affiliationNameIdentifierScheme":"ISNI","affiliationNameIdentifierURI":"http://www.isni.org/isni/"}],"affiliationNames":[{"affiliationName":"","affiliationNameLang":"ja"}]}],"creatorNames":[{"creatorName":"坂東, 良美","creatorNameLang":"ja"},{"creatorName":"バンドウ, ヨシミ","creatorNameLang":"ja-Kana"},{"creatorName":"Bando, Yoshimi","creatorNameLang":"en"}],"familyNames":[{"familyName":"坂東","familyNameLang":"ja"},{"familyName":"バンドウ","familyNameLang":"ja-Kana"},{"familyName":"Bando","familyNameLang":"en"}],"givenNames":[{"givenName":"良美","givenNameLang":"ja"},{"givenName":"ヨシミ","givenNameLang":"ja-Kana"},{"givenName":"Yoshimi","givenNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"1559","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"60096/profile-ja.html","nameIdentifierScheme":"徳島大学 教育研究者総覧","nameIdentifierURI":"http://pub2.db.tokushima-u.ac.jp/ERD/person/60096/profile-ja.html"},{"nameIdentifier":"00238239","nameIdentifierScheme":"e-Rad","nameIdentifierURI":"https://nrid.nii.ac.jp/ja/search/?qm=00238239"}]},{"creatorAffiliations":[{"affiliationNameIdentifiers":[{"affiliationNameIdentifier":"","affiliationNameIdentifierScheme":"ISNI","affiliationNameIdentifierURI":"http://www.isni.org/isni/"}],"affiliationNames":[{"affiliationName":"","affiliationNameLang":"ja"}]}],"creatorNames":[{"creatorName":"上原, 久典","creatorNameLang":"ja"},{"creatorName":"ウエハラ, ヒサノリ","creatorNameLang":"ja-Kana"},{"creatorName":"Uehara, Hisanori","creatorNameLang":"en"}],"familyNames":[{"familyName":"上原","familyNameLang":"ja"},{"familyName":"ウエハラ","familyNameLang":"ja-Kana"},{"familyName":"Uehara","familyNameLang":"en"}],"givenNames":[{"givenName":"久典","givenNameLang":"ja"},{"givenName":"ヒサノリ","givenNameLang":"ja-Kana"},{"givenName":"Hisanori","givenNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"1548","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"60072/profile-ja.html","nameIdentifierScheme":"徳島大学 教育研究者総覧","nameIdentifierURI":"http://pub2.db.tokushima-u.ac.jp/ERD/person/60072/profile-ja.html"},{"nameIdentifier":"30263809","nameIdentifierScheme":"e-Rad","nameIdentifierURI":"https://nrid.nii.ac.jp/ja/search/?qm=30263809"}]},{"creatorAffiliations":[{"affiliationNameIdentifiers":[{"affiliationNameIdentifier":"","affiliationNameIdentifierScheme":"ISNI","affiliationNameIdentifierURI":"http://www.isni.org/isni/"}],"affiliationNames":[{"affiliationName":"","affiliationNameLang":"ja"}]}],"creatorNames":[{"creatorName":"近藤, 和也","creatorNameLang":"ja"},{"creatorName":"コンドウ, カズヤ","creatorNameLang":"ja-Kana"},{"creatorName":"Kondo, Kazuya","creatorNameLang":"en"}],"familyNames":[{"familyName":"近藤","familyNameLang":"ja"},{"familyName":"コンドウ","familyNameLang":"ja-Kana"},{"familyName":"Kondo","familyNameLang":"en"}],"givenNames":[{"givenName":"和也","givenNameLang":"ja"},{"givenName":"カズヤ","givenNameLang":"ja-Kana"},{"givenName":"Kazuya","givenNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"1540","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"60056/profile-ja.html","nameIdentifierScheme":"徳島大学 教育研究者総覧","nameIdentifierURI":"http://pub2.db.tokushima-u.ac.jp/ERD/person/60056/profile-ja.html"},{"nameIdentifier":"10263815","nameIdentifierScheme":"e-Rad","nameIdentifierURI":"https://nrid.nii.ac.jp/ja/search/?qm=10263815"}]},{"creatorAffiliations":[{"affiliationNameIdentifiers":[{"affiliationNameIdentifier":"","affiliationNameIdentifierScheme":"ISNI","affiliationNameIdentifierURI":"http://www.isni.org/isni/"}],"affiliationNames":[{"affiliationName":"","affiliationNameLang":"ja"}]}],"creatorNames":[{"creatorName":"丹黒, 章","creatorNameLang":"ja"},{"creatorName":"タンゴク, アキラ","creatorNameLang":"ja-Kana"},{"creatorName":"Tangoku, Akira","creatorNameLang":"en"}],"familyNames":[{"familyName":"丹黒","familyNameLang":"ja"},{"familyName":"タンゴク","familyNameLang":"ja-Kana"},{"familyName":"Tangoku","familyNameLang":"en"}],"givenNames":[{"givenName":"章","givenNameLang":"ja"},{"givenName":"アキラ","givenNameLang":"ja-Kana"},{"givenName":"Akira","givenNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"176","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"113573/profile-ja.html","nameIdentifierScheme":"徳島大学 教育研究者総覧","nameIdentifierURI":"http://pub2.db.tokushima-u.ac.jp/ERD/person/113573/profile-ja.html"},{"nameIdentifier":"10197593","nameIdentifierScheme":"e-Rad","nameIdentifierURI":"https://nrid.nii.ac.jp/ja/search/?qm=10197593"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_access","date":[{"dateType":"Available","dateValue":"2020-10-13"}],"displaytype":"detail","filename":"k3461_abstract_review.pdf","filesize":[{"value":"240 KB"}],"format":"application/pdf","mimetype":"application/pdf","url":{"objectType":"abstract","url":"https://tokushima-u.repo.nii.ac.jp/record/2008265/files/k3461_abstract_review.pdf"},"version_id":"ae907655-0a5c-440e-8f1c-8bb812029841"},{"accessrole":"open_access","date":[{"dateType":"Available","dateValue":"2021-02-08"}],"displaytype":"detail","filename":"k3461_fulltext.pdf","filesize":[{"value":"1.22 MB"}],"format":"application/pdf","mimetype":"application/pdf","url":{"objectType":"fulltext","url":"https://tokushima-u.repo.nii.ac.jp/record/2008265/files/k3461_fulltext.pdf"},"version_id":"d5a88a60-55de-4fe5-a71c-9043b4ff34c8"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"anaplastic thyroid carcinoma","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"orthotopic model","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"18F-FDG PET/CT","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"paclitaxel","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"lenvatinib","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"doctoral thesis","resourceuri":"http://purl.org/coar/resource_type/c_db06"}]},"item_title":"Non-invasive monitoring of paclitaxel and lenvatinib efficacy against anaplastic thyroid cancer in orthotopic SCID mouse models using small-animal FDG-PET/CT","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Non-invasive monitoring of paclitaxel and lenvatinib efficacy against anaplastic thyroid cancer in orthotopic SCID mouse models using small-animal FDG-PET/CT","subitem_title_language":"en"}]},"item_type_id":"40001","owner":"7","path":["1716268551628"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2020-10-13"},"publish_date":"2020-10-13","publish_status":"0","recid":"2008265","relation_version_is_last":true,"title":["Non-invasive monitoring of paclitaxel and lenvatinib efficacy against anaplastic thyroid cancer in orthotopic SCID mouse models using small-animal FDG-PET/CT"],"weko_creator_id":"7","weko_shared_id":-1},"updated":"2025-02-13T01:52:59.519098+00:00"}