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We report in situ click chemistry screening with human D-amino acid oxidase (hDAO), which led to the identification of a more potent hDAO inhibitor. The hDAO inhibitors have chemotherapeutic potential as antipsychotic agents. The new inhibitor displayed competitive inhibition of hDAO and showed significantly increased inhibitory activity against hDAO compared with that of an anchor molecule of in situ click chemistry.","subitem_description_language":"en","subitem_description_type":"Abstract"}]},"item_10001_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"The Pharmaceutical Society of Japan","subitem_publisher_language":"en"}]},"item_10001_source_id_9":{"attribute_name":"収録物ID","attribute_value_mlt":[{"subitem_source_identifier":"00092363","subitem_source_identifier_type":"ISSN"},{"subitem_source_identifier":"13475223","subitem_source_identifier_type":"ISSN"},{"subitem_source_identifier":"AA00602100","subitem_source_identifier_type":"NCID"}]},"item_10001_version_type_20":{"attribute_name":"出版タイプ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_1715043197608":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"open access"}]},"item_1722929371688":{"attribute_name":"出版社版DOI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_language":"ja","subitem_relation_name_text":"10.1248/cpb.c15-00867"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://doi.org/10.1248/cpb.c15-00867","subitem_relation_type_select":"DOI"}}]},"item_1723180141928":{"attribute_name":"EID","attribute_value_mlt":[{"subitem_identifier_type":"URI","subitem_identifier_uri":"314631"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"トグチ, ショウヘイ","creatorNameLang":"ja"},{"creatorName":"トグチ, ショウヘイ","creatorNameLang":"ja-Kana"},{"creatorName":"Toguchi, Shohei","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"ヒロセ, トモヤス","creatorNameLang":"ja"},{"creatorName":"ヒロセ, トモヤス","creatorNameLang":"ja-Kana"},{"creatorName":"Hirose, Tomoyasu","creatorNameLang":"en"}]},{"creatorAffiliations":[{"affiliationNameIdentifiers":[{"affiliationNameIdentifier":"","affiliationNameIdentifierScheme":"ISNI","affiliationNameIdentifierURI":"http://www.isni.org/isni/"}],"affiliationNames":[{"affiliationName":"","affiliationNameLang":"ja"}]}],"creatorNames":[{"creatorName":"頼田, 和子","creatorNameLang":"ja"},{"creatorName":"ヨリタ, カズコ","creatorNameLang":"ja-Kana"},{"creatorName":"Yorita, Kazuko","creatorNameLang":"en"}],"familyNames":[{"familyName":"頼田","familyNameLang":"ja"},{"familyName":"ヨリタ","familyNameLang":"ja-Kana"},{"familyName":"Yorita","familyNameLang":"en"}],"givenNames":[{"givenName":"和子","givenNameLang":"ja"},{"givenName":"カズコ","givenNameLang":"ja-Kana"},{"givenName":"Kazuko","givenNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"162","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"60116879","nameIdentifierScheme":"e-Rad","nameIdentifierURI":"https://nrid.nii.ac.jp/ja/search/?qm=60116879"}]},{"creatorAffiliations":[{"affiliationNameIdentifiers":[{"affiliationNameIdentifier":"","affiliationNameIdentifierScheme":"ISNI","affiliationNameIdentifierURI":"http://www.isni.org/isni/"}],"affiliationNames":[{"affiliationName":"","affiliationNameLang":"ja"}]}],"creatorNames":[{"creatorName":"福井, 清","creatorNameLang":"ja"},{"creatorName":"フクイ, キヨシ","creatorNameLang":"ja-Kana"},{"creatorName":"Fukui, Kiyoshi","creatorNameLang":"en"}],"familyNames":[{"familyName":"福井","familyNameLang":"ja"},{"familyName":"フクイ","familyNameLang":"ja-Kana"},{"familyName":"Fukui","familyNameLang":"en"}],"givenNames":[{"givenName":"清","givenNameLang":"ja"},{"givenName":"キヨシ","givenNameLang":"ja-Kana"},{"givenName":"Kiyoshi","givenNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"271","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"15881/profile-ja.html","nameIdentifierScheme":"徳島大学 教育研究者総覧","nameIdentifierURI":"http://pub2.db.tokushima-u.ac.jp/ERD/person/15881/profile-ja.html"},{"nameIdentifier":"00175564","nameIdentifierScheme":"e-Rad","nameIdentifierURI":"https://nrid.nii.ac.jp/ja/search/?qm=00175564"}]},{"creatorNames":[{"creatorName":"Sharpless, K. Barry","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"オオムラ, サトシ","creatorNameLang":"ja"},{"creatorName":"オオムラ, サトシ","creatorNameLang":"ja-Kana"},{"creatorName":"Ōmura, Satoshi","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"スナヅカ, トシアキ","creatorNameLang":"ja"},{"creatorName":"スナヅカ, トシアキ","creatorNameLang":"ja-Kana"},{"creatorName":"Sunazuka, Toshiaki","creatorNameLang":"en"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_access","date":[{"dateType":"Available","dateValue":"2020-11-12"}],"displaytype":"detail","filename":"cpb_64_7_695.pdf","filesize":[{"value":"1.41 MB"}],"format":"application/pdf","mimetype":"application/pdf","url":{"objectType":"fulltext","url":"https://tokushima-u.repo.nii.ac.jp/record/2008359/files/cpb_64_7_695.pdf"},"version_id":"e669f07c-fbc9-4860-8b95-46ee80dadd4c"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"fragment-based lead discovery","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"templated reaction","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"ligand-binding site","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"drug discovery","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"triazole formation","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"ligand affinity","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"In Situ Click Chemistry for the Identification of a Potent D-Amino Acid Oxidase Inhibitor","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"In Situ Click Chemistry for the Identification of a Potent D-Amino Acid Oxidase Inhibitor","subitem_title_language":"en"}]},"item_type_id":"40001","owner":"7","path":["1713853295607"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2020-11-12"},"publish_date":"2020-11-12","publish_status":"0","recid":"2008359","relation_version_is_last":true,"title":["In Situ Click Chemistry for the Identification of a Potent D-Amino Acid Oxidase Inhibitor"],"weko_creator_id":"7","weko_shared_id":-1},"updated":"2025-02-13T05:36:58.343258+00:00"}