| アイテムタイプ |
文献 / Documents(1) |
| 公開日 |
2021-02-26 |
| アクセス権 |
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アクセス権 |
open access |
| 資源タイプ |
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資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
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資源タイプ |
journal article |
| 出版社版DOI |
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関連識別子 |
https://doi.org/10.3390/md18020092 |
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関連名称 |
10.3390/md18020092 |
| 出版タイプ |
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出版タイプ |
VoR |
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出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
| タイトル |
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タイトル |
Synthesis and Antimicrobial Evaluation of Side-Chain Derivatives based on Eurotiumide A |
| 著者 |
中山, 淳
サトウ, ヒデオ
ナカムラ, テンタ
ハマダ, マイ
ナガノ, シュウジ
カメヤマ, シュウヘイ
フルエ, ユイ
ハヤシ, ナオキ
カモシダ, ゴウ
カランジット, サンギータ
オダ, マサタカ
難波, 康祐
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| 抄録 |
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内容記述 |
Side-chain derivatives of eurotiumide A, a dihydroisochroman-type natural product, have been synthesized and their antimicrobial activities described. Sixteen derivatives were synthesized from a key intermediate of the total synthesis of eurotiumide A, and their antimicrobial activities against two Gram-positive bacteria, methicillin-susceptible and methicillin-resistant Staphylococcus aureus (MSSA and MRSA), and a Gram-negative bacterium, Porphyromonas gingivalis, were evaluated. The results showed that derivatives having an iodine atom on their aromatic ring instead of the prenyl moiety displayed better antimicrobial activity than eurotiumide A against MSSA and P. gingivalis. Moreover, we discovered that a derivative with an isopentyl side chain, which is a hydrogenated product of eurotiumide A, is the strongest antimicrobial agent against all three strains, including MRSA. |
| キーワード |
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主題 |
antibiotics |
| キーワード |
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主題 |
natural product |
| キーワード |
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主題 |
P. gingivalis |
| キーワード |
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主題 |
methicillin-resistant S. aureus |
| 書誌情報 |
en : Marine Drugs
巻 18,
号 2,
p. 92,
発行日 2020-01-30
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| 収録物ID |
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収録物識別子タイプ |
ISSN |
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収録物識別子 |
16603397 |
| 出版者 |
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出版者 |
MDPI |
| 権利情報 |
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権利情報 |
This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
| EID |
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識別子 |
362831 |
| 言語 |
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言語 |
eng |
md_18_2_92.pdf (1.73 MB)
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