{"created":"2024-11-22T07:20:17.940614+00:00","id":2008521,"links":{},"metadata":{"_buckets":{"deposit":"175ec0db-b816-46c2-9096-cc2bc7b32a14"},"_deposit":{"created_by":7,"id":"2008521","owners":[7],"pid":{"revision_id":0,"type":"depid","value":"2008521"},"status":"published"},"_oai":{"id":"oai:tokushima-u.repo.nii.ac.jp:02008521","sets":["1713853213384:1713853295607"]},"author_link":["424","1519"],"control_number":"2008521","item_10001_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2020-05-04","bibliographicIssueDateType":"Issued"},"bibliographicPageStart":"2198","bibliographicVolumeNumber":"11","bibliographic_titles":[{"bibliographic_title":"Nature Communications","bibliographic_titleLang":"en"}]}]},"item_10001_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"The thymus supports multiple αβ T cell lineages that are functionally distinct, but mechanisms that control this multifaceted development are poorly understood. Here we examine medullary thymic epithelial cell (mTEC) heterogeneity and its influence on CD1d-restricted iNKT cells. We find three distinct mTEClow subsets distinguished by surface, intracellular and secreted molecules, and identify LTβR as a cell-autonomous controller of their development. Importantly, this mTEC heterogeneity enables the thymus to differentially control iNKT sublineages possessing distinct effector properties. mTEC expression of LTβR is essential for the development thymic tuft cells which regulate NKT2 via IL-25, while LTβR controls CD104+ CCL21+ mTEClow that are capable of IL-15-transpresentation for regulating NKT1 and NKT17.  Finally, mTECs regulate both iNKT-mediated activation of thymic dendritic cells, and iNKT availability in extrathymic sites. In conclusion, mTEC specialization controls intrathymic iNKT cell development and function, and determines iNKT pool size in peripheral tissues.","subitem_description_language":"en","subitem_description_type":"Abstract"}]},"item_10001_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Springer Nature","subitem_publisher_language":"en"}]},"item_10001_rights_15":{"attribute_name":"権利情報","attribute_value_mlt":[{"subitem_rights":"This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.","subitem_rights_language":"en"}]},"item_10001_source_id_9":{"attribute_name":"収録物ID","attribute_value_mlt":[{"subitem_source_identifier":"20411723","subitem_source_identifier_type":"ISSN"},{"subitem_source_identifier":"AA12645905","subitem_source_identifier_type":"NCID"}]},"item_10001_version_type_20":{"attribute_name":"出版タイプ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_1715043197608":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"open 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D.","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Jones, Nick D.","creatorNameLang":"en"}]},{"creatorAffiliations":[{"affiliationNameIdentifiers":[{"affiliationNameIdentifier":"","affiliationNameIdentifierScheme":"ISNI","affiliationNameIdentifierURI":"http://www.isni.org/isni/"}],"affiliationNames":[{"affiliationName":"","affiliationNameLang":"ja"}]}],"creatorNames":[{"creatorName":"大東, いずみ","creatorNameLang":"ja"},{"creatorName":"オオヒガシ, イズミ","creatorNameLang":"ja-Kana"},{"creatorName":"Ohigashi, Izumi","creatorNameLang":"en"}],"familyNames":[{"familyName":"大東","familyNameLang":"ja"},{"familyName":"オオヒガシ","familyNameLang":"ja-Kana"},{"familyName":"Ohigashi","familyNameLang":"en"}],"givenNames":[{"givenName":"いずみ","givenNameLang":"ja"},{"givenName":"イズミ","givenNameLang":"ja-Kana"},{"givenName":"Izumi","givenNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"424","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"207340/profile-ja.html","nameIdentifierScheme":"徳島大学 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cells","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Diversity in medullary thymic epithelial cells controls the activity and availability of iNKT cells","subitem_title_language":"en"}]},"item_type_id":"40001","owner":"7","path":["1713853295607"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2021-02-10"},"publish_date":"2021-02-10","publish_status":"0","recid":"2008521","relation_version_is_last":true,"title":["Diversity in medullary thymic epithelial cells controls the activity and availability of iNKT cells"],"weko_creator_id":"7","weko_shared_id":-1},"updated":"2025-02-10T06:50:26.653826+00:00"}