{"created":"2024-11-22T07:20:45.793288+00:00","id":2008526,"links":{},"metadata":{"_buckets":{"deposit":"476e2db6-ec68-4a57-a9db-4b855fd4f85f"},"_deposit":{"created_by":7,"id":"2008526","owners":[7],"pid":{"revision_id":0,"type":"depid","value":"2008526"},"status":"published"},"_oai":{"id":"oai:tokushima-u.repo.nii.ac.jp:02008526","sets":["1713853213384:1713853295607"]},"author_link":["339"],"control_number":"2008526","item_10001_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2019-11-29","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"4","bibliographicPageEnd":"895","bibliographicPageStart":"883","bibliographicVolumeNumber":"25","bibliographic_titles":[{"bibliographic_title":"Molecular Psychiatry","bibliographic_titleLang":"en"}]}]},"item_10001_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Identifying both the commonalities and differences in brain structures among psychiatric disorders is important for understanding the pathophysiology. Recently, the ENIGMA-Schizophrenia DTI Working Group performed a large-scale meta-analysis and reported widespread white matter microstructural alterations in schizophrenia; however, no similar cross-disorder study has been carried out to date. Here, we conducted mega-analyses comparing white matter microstructural differences between healthy comparison subjects (HCS; N = 1506) and patients with schizophrenia (N = 696), bipolar disorder (N = 211), autism spectrum disorder (N = 126), or major depressive disorder (N = 398; total N = 2937 from 12 sites). In comparison with HCS, we found that schizophrenia, bipolar disorder, and autism spectrum disorder share similar white matter microstructural differences in the body of the corpus callosum; schizophrenia and bipolar disorder featured comparable changes in the limbic system, such as the fornix and cingulum. By comparison, alterations in tracts connecting neocortical areas, such as the uncinate fasciculus, were observed only in schizophrenia. No significant difference was found in major depressive disorder. In a direct comparison between schizophrenia and bipolar disorder, there were no significant differences. Significant differences between schizophrenia/bipolar disorder and major depressive disorder were found in the limbic system, which were similar to the differences in schizophrenia and bipolar disorder relative to HCS. While schizophrenia and bipolar disorder may have similar pathological characteristics, the biological characteristics of major depressive disorder may be close to those of HCS. Our findings provide insights into nosology and encourage further investigations of shared and unique pathophysiology of psychiatric disorders.","subitem_description_language":"en","subitem_description_type":"Abstract"}]},"item_10001_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Springer Nature","subitem_publisher_language":"en"}]},"item_10001_rights_15":{"attribute_name":"権利情報","attribute_value_mlt":[{"subitem_rights":"This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.","subitem_rights_language":"en"}]},"item_10001_source_id_9":{"attribute_name":"収録物ID","attribute_value_mlt":[{"subitem_source_identifier":"13594184","subitem_source_identifier_type":"ISSN"},{"subitem_source_identifier":"14765578","subitem_source_identifier_type":"ISSN"},{"subitem_source_identifier":"AA11164978","subitem_source_identifier_type":"NCID"},{"subitem_source_identifier":"AA12909982","subitem_source_identifier_type":"NCID"}]},"item_10001_version_type_20":{"attribute_name":"出版タイプ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_1715043197608":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"open access"}]},"item_1722929371688":{"attribute_name":"出版社版DOI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_language":"ja","subitem_relation_name_text":"10.1038/s41380-019-0553-7"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://doi.org/10.1038/s41380-019-0553-7","subitem_relation_type_select":"DOI"}}]},"item_1723180141928":{"attribute_name":"EID","attribute_value_mlt":[{"subitem_identifier_type":"URI","subitem_identifier_uri":"368129"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"コシヤマ, ダイスケ","creatorNameLang":"ja"},{"creatorName":"コシヤマ, ダイスケ","creatorNameLang":"ja-Kana"},{"creatorName":"Koshiyama, Daisuke","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"フクナガ, マサキ","creatorNameLang":"ja"},{"creatorName":"フクナガ, マサキ","creatorNameLang":"ja-Kana"},{"creatorName":"Fukunaga, Masaki","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"オカダ, ナオヒロ","creatorNameLang":"ja"},{"creatorName":"オカダ, ナオヒロ","creatorNameLang":"ja-Kana"},{"creatorName":"Okada, Naohiro","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"モリタ, ケンタロウ","creatorNameLang":"ja"},{"creatorName":"モリタ, ケンタロウ","creatorNameLang":"ja-Kana"},{"creatorName":"Morita, Kentaro","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"ネモト, キヨタカ","creatorNameLang":"ja"},{"creatorName":"ネモト, キヨタカ","creatorNameLang":"ja-Kana"},{"creatorName":"Nemoto, Kiyotaka","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"ウスイ, カオリ","creatorNameLang":"ja"},{"creatorName":"ウスイ, カオリ","creatorNameLang":"ja-Kana"},{"creatorName":"Usui, Kaori","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"ヤマモリ, ヒデナガ","creatorNameLang":"ja"},{"creatorName":"ヤマモリ, ヒデナガ","creatorNameLang":"ja-Kana"},{"creatorName":"Yamamori, Hidenaga","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"ヤスダ, ユカ","creatorNameLang":"ja"},{"creatorName":"ヤスダ, 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コウジ","creatorNameLang":"ja-Kana"},{"creatorName":"Matsuo, Koji","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"ヤマスエ, ヒデノリ","creatorNameLang":"ja"},{"creatorName":"ヤマスエ, ヒデノリ","creatorNameLang":"ja-Kana"},{"creatorName":"Yamasue, Hidenori","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"アベ, オサム","creatorNameLang":"ja"},{"creatorName":"アベ, オサム","creatorNameLang":"ja-Kana"},{"creatorName":"Abe, Osamu","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"ハシモト, リュウイチロウ","creatorNameLang":"ja"},{"creatorName":"ハシモト, リュウイチロウ","creatorNameLang":"ja-Kana"},{"creatorName":"Hashimoto, Ryuichiro","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"タカハシ, ツトム","creatorNameLang":"ja"},{"creatorName":"タカハシ, ツトム","creatorNameLang":"ja-Kana"},{"creatorName":"Takahashi, Tsutomu","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"ホリ, トモキ","creatorNameLang":"ja"},{"creatorName":"ホリ, トモキ","creatorNameLang":"ja-Kana"},{"creatorName":"Hori, 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M.","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Turner, Jessica","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Donohoe, Gary","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Thompson, Paul M.","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"カサイ, キヨト","creatorNameLang":"ja"},{"creatorName":"カサイ, キヨト","creatorNameLang":"ja-Kana"},{"creatorName":"Kasai, Kiyoto","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"ハシモト, リョウタ","creatorNameLang":"ja"},{"creatorName":"ハシモト, リョウタ","creatorNameLang":"ja-Kana"},{"creatorName":"Hashimoto, Ryota","creatorNameLang":"en"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_access","date":[{"dateType":"Available","dateValue":"2021-03-02"}],"displaytype":"detail","filename":"mp_25_4_883.pdf","filesize":[{"value":"1.48 MB"}],"format":"application/pdf","licensetype":"license_0","mimetype":"application/pdf","url":{"objectType":"fulltext","url":"https://tokushima-u.repo.nii.ac.jp/record/2008526/files/mp_25_4_883.pdf"},"version_id":"fa387081-572a-4bf1-8ece-8fb015d98a66"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"White matter microstructural alterations across four major psychiatric disorders : mega-analysis study in 2937 individuals","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"White matter microstructural alterations across four major psychiatric disorders : mega-analysis study in 2937 individuals","subitem_title_language":"en"}]},"item_type_id":"40001","owner":"7","path":["1713853295607"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2021-03-02"},"publish_date":"2021-03-02","publish_status":"0","recid":"2008526","relation_version_is_last":true,"title":["White matter microstructural alterations across four major psychiatric disorders : mega-analysis study in 2937 individuals"],"weko_creator_id":"7","weko_shared_id":-1},"updated":"2025-01-28T01:11:08.239522+00:00"}