{"created":"2024-11-22T07:23:24.107428+00:00","id":2008555,"links":{},"metadata":{"_buckets":{"deposit":"e959e8e9-df34-49a6-bcc0-4f65b845ee34"},"_deposit":{"created_by":7,"id":"2008555","owners":[7],"pid":{"revision_id":0,"type":"depid","value":"2008555"},"status":"published"},"_oai":{"id":"oai:tokushima-u.repo.nii.ac.jp:02008555","sets":["1713853213384:1713853295607"]},"author_link":["908"],"control_number":"2008555","item_10001_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2016-06-15","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"6","bibliographicPageStart":"954","bibliographicVolumeNumber":"17","bibliographic_titles":[{"bibliographic_title":"International Journal of Molecular Sciences","bibliographic_titleLang":"en"}]}]},"item_10001_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Oxidative stress is considered to play key roles in aging and pathogenesis of many neurodegenerative diseases such as Parkinson’s disease, which could bring DNA damage by cells. The DNA damage may lead to the cell apoptosis, which could contribute to the degeneration of neuronal tissues. Recent evidence suggests that PTEN (phosphatase and tensin homolog on chromosome 10) may be involved in the pathophysiology of the neurodegenerative disorders. Since PTEN expression appears to be one dominant determinant of the neuronal cell death, PTEN should be a potential molecular target of novel therapeutic strategies against Parkinson’s disease. In addition, defects in DNA damage response and DNA repair are often associated with modulation of hormone signaling pathways. Especially, many observations imply a role for estrogen in a regulation of the DNA repair action. In the present review, we have attempted to summarize the function of DNA repair molecules at a viewpoint of the PTEN signaling pathway and the hormone related functional modulation of cells, providing a broad interpretation on the molecular mechanisms for treatment of Parkinson’s disease. Particular attention will be paid to the mechanisms proposed to explain the health effects of food ingredients against Parkinson’s disease related to reduce oxidative stress for an efficient therapeutic intervention.","subitem_description_language":"en","subitem_description_type":"Abstract"}]},"item_10001_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"MDPI","subitem_publisher_language":"en"}]},"item_10001_rights_15":{"attribute_name":"権利情報","attribute_value_mlt":[{"subitem_rights":"© 2016 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC-BY) license (http://creativecommons.org/licenses/by/4.0/).","subitem_rights_language":"en"}]},"item_10001_source_id_9":{"attribute_name":"収録物ID","attribute_value_mlt":[{"subitem_source_identifier":"14220067","subitem_source_identifier_type":"ISSN"},{"subitem_source_identifier":"16616596","subitem_source_identifier_type":"ISSN"},{"subitem_source_identifier":"AA12038549","subitem_source_identifier_type":"NCID"}]},"item_10001_version_type_20":{"attribute_name":"出版タイプ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_1715043197608":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"open access"}]},"item_1722929371688":{"attribute_name":"出版社版DOI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_language":"ja","subitem_relation_name_text":"10.3390/ijms17060954"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://doi.org/10.3390/ijms17060954","subitem_relation_type_select":"DOI"}}]},"item_1723180141928":{"attribute_name":"EID","attribute_value_mlt":[{"subitem_identifier_type":"URI","subitem_identifier_uri":"369429"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"オギノ, マコ","creatorNameLang":"ja"},{"creatorName":"オギノ, マコ","creatorNameLang":"ja-Kana"},{"creatorName":"Ogino, Mako","creatorNameLang":"en"}]},{"creatorAffiliations":[{"affiliationNameIdentifiers":[{"affiliationNameIdentifier":"","affiliationNameIdentifierScheme":"ISNI","affiliationNameIdentifierURI":"http://www.isni.org/isni/"}],"affiliationNames":[{"affiliationName":"","affiliationNameLang":"ja"}]}],"creatorNames":[{"creatorName":"(市村)清水, 真祐子","creatorNameLang":"ja"},{"creatorName":"(イチムラ)シミズ, マユコ","creatorNameLang":"ja-Kana"},{"creatorName":"Ichimura-Shimizu, Mayuko","creatorNameLang":"en"}],"familyNames":[{"familyName":"(市村)清水","familyNameLang":"ja"},{"familyName":"(イチムラ)シミズ","familyNameLang":"ja-Kana"},{"familyName":"Ichimura-Shimizu","familyNameLang":"en"}],"givenNames":[{"givenName":"真祐子","givenNameLang":"ja"},{"givenName":"マユコ","givenNameLang":"ja-Kana"},{"givenName":"Mayuko","givenNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"908","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"336324/profile-ja.html","nameIdentifierScheme":"徳島大学 教育研究者総覧","nameIdentifierURI":"http://pub2.db.tokushima-u.ac.jp/ERD/person/336324/profile-ja.html"}]},{"creatorNames":[{"creatorName":"ナカノ, ノリコ","creatorNameLang":"ja"},{"creatorName":"ナカノ, ノリコ","creatorNameLang":"ja-Kana"},{"creatorName":"Nakano, Noriko","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"ミナミ, アカリ","creatorNameLang":"ja"},{"creatorName":"ミナミ, アカリ","creatorNameLang":"ja-Kana"},{"creatorName":"Minami, Akari","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"キタギシ, ヤスコ","creatorNameLang":"ja"},{"creatorName":"キタギシ, ヤスコ","creatorNameLang":"ja-Kana"},{"creatorName":"Kitagishi, Yasuko","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"マツダ, サトル","creatorNameLang":"ja"},{"creatorName":"マツダ, サトル","creatorNameLang":"ja-Kana"},{"creatorName":"Matsuda, Satoru","creatorNameLang":"en"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_access","date":[{"dateType":"Available","dateValue":"2021-02-16"}],"displaytype":"detail","filename":"ijms_17_6_954.pdf","filesize":[{"value":"496 KB"}],"format":"application/pdf","licensetype":"license_0","mimetype":"application/pdf","url":{"objectType":"fulltext","url":"https://tokushima-u.repo.nii.ac.jp/record/2008555/files/ijms_17_6_954.pdf"},"version_id":"1fa3e76f-1069-4a04-81ae-bcd8bb2bf11f"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"oxidative stress","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"ROS","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"DNA repair","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"PTEN","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"BRCA1","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"estrogen","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Parkinson’s disease","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Roles of PTEN with DNA Repair in Parkinson’s Disease","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Roles of PTEN with DNA Repair in Parkinson’s Disease","subitem_title_language":"en"}]},"item_type_id":"40001","owner":"7","path":["1713853295607"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2021-02-16"},"publish_date":"2021-02-16","publish_status":"0","recid":"2008555","relation_version_is_last":true,"title":["Roles of PTEN with DNA Repair in Parkinson’s Disease"],"weko_creator_id":"7","weko_shared_id":-1},"updated":"2025-02-13T06:41:53.968382+00:00"}