{"created":"2024-11-22T07:23:35.364248+00:00","id":2008557,"links":{},"metadata":{"_buckets":{"deposit":"a8a8c8bb-5d8f-4ba0-af02-c2d4b1821c44"},"_deposit":{"created_by":7,"id":"2008557","owners":[7],"pid":{"revision_id":0,"type":"depid","value":"2008557"},"status":"published"},"_oai":{"id":"oai:tokushima-u.repo.nii.ac.jp:02008557","sets":["1713853213384:1713853295607"]},"author_link":["872"],"item_10001_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2020-03-11","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"6","bibliographicPageStart":"1906","bibliographicVolumeNumber":"21","bibliographic_titles":[{"bibliographic_title":"International Journal of Molecular Sciences","bibliographic_titleLang":"en"}]}]},"item_10001_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Acidic glycosphingolipids, i.e., gangliosides, are predominantly and consistently expressed in nervous tissues of vertebrates at high levels. Therefore, they are considered to be involved in the development and function of nervous systems. Recent studies involving genetic engineering of glycosyltransferase genes have revealed novel aspects of the roles of gangliosides in the regulation of nervous tissues. In this review, novel findings regarding ganglioside functions and their modes of action elucidated mainly by studies of gene knockout mice are summarized. In particular, the roles of gangliosides in the regulation of lipid rafts to maintain the integrity of nervous systems are reported with a focus on the roles in the regulation of neuro-inflammation and neurodegeneration via complement systems. In addition, recent advances in studies of congenital neurological disorders due to genetic mutations of ganglioside synthase genes and also in the techniques for the analysis of ganglioside functions are introduced.","subitem_description_language":"en","subitem_description_type":"Abstract"}]},"item_10001_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"MDPI","subitem_publisher_language":"en"}]},"item_10001_rights_15":{"attribute_name":"権利情報","attribute_value_mlt":[{"subitem_rights":"© 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).","subitem_rights_language":"en"}]},"item_10001_source_id_9":{"attribute_name":"収録物ID","attribute_value_mlt":[{"subitem_source_identifier":"14220067","subitem_source_identifier_type":"ISSN"},{"subitem_source_identifier":"16616596","subitem_source_identifier_type":"ISSN"},{"subitem_source_identifier":"AA12038549","subitem_source_identifier_type":"NCID"}]},"item_10001_version_type_20":{"attribute_name":"出版タイプ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_1715043197608":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"open 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Farhana","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"タジマ, オリエ","creatorNameLang":"ja"},{"creatorName":"タジマ, オリエ","creatorNameLang":"ja-Kana"},{"creatorName":"Tajima, Orie","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"コンドウ, ユウジ","creatorNameLang":"ja"},{"creatorName":"コンドウ, ユウジ","creatorNameLang":"ja-Kana"},{"creatorName":"Kondo, Yuji","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Zhang, Pu","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"橋本, 登","creatorNameLang":"ja"}],"nameIdentifiers":[{"nameIdentifier":"872","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"オオカワ, ユウキ","creatorNameLang":"ja"},{"creatorName":"オオカワ, ユウキ","creatorNameLang":"ja-Kana"},{"creatorName":"Ohkawa, Yuki","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Bhuiyan, Robiul H.","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"フルカワ, ケイコ","creatorNameLang":"ja"},{"creatorName":"フルカワ, ケイコ","creatorNameLang":"ja-Kana"},{"creatorName":"Furukawa, Keiko","creatorNameLang":"en"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_access","date":[{"dateType":"Available","dateValue":"2021-02-16"}],"displaytype":"detail","filename":"ijms_21_6_1906.pdf","filesize":[{"value":"1.42 MB"}],"format":"application/pdf","mimetype":"application/pdf","url":{"objectType":"fulltext","url":"https://tokushima-u.repo.nii.ac.jp/record/2008557/files/ijms_21_6_1906.pdf"},"version_id":"26962376-a50b-4ea3-991e-97c843fa5f00"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"ganglioside","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"knockout","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"neurodegeneration","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"glycosphingolipid","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"inflammation","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"microdomain","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Novel Molecular Mechanisms of Gangliosides in the Nervous System Elucidated by Genetic Engineering","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Novel Molecular Mechanisms of Gangliosides in the Nervous System Elucidated by Genetic Engineering","subitem_title_language":"en"}]},"item_type_id":"40001","owner":"7","path":["1713853295607"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2021-02-16"},"publish_date":"2021-02-16","publish_status":"0","recid":"2008557","relation_version_is_last":true,"title":["Novel Molecular Mechanisms of Gangliosides in the Nervous System Elucidated by Genetic Engineering"],"weko_creator_id":"7","weko_shared_id":-1},"updated":"2024-11-22T07:23:49.157706+00:00"}