{"created":"2024-11-22T07:25:00.221443+00:00","id":2008571,"links":{},"metadata":{"_buckets":{"deposit":"b362e153-216e-4768-8c3c-58176effaa4e"},"_deposit":{"created_by":7,"id":"2008571","owners":[7],"pid":{"revision_id":0,"type":"depid","value":"2008571"},"status":"published"},"_oai":{"id":"oai:tokushima-u.repo.nii.ac.jp:02008571","sets":["1713853213384:1713853296295:1716267876683:1716268551628"]},"author_link":["193","1253"],"item_10001_alternative_title_1":{"attribute_name":"タイトル別表記","attribute_value_mlt":[{"subitem_alternative_title":"日本の伝統的な漢方薬である大建中湯は推進性の運動パターンを誘導することにより結腸輸送を促進する","subitem_alternative_title_language":"ja"}]},"item_10001_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2019-08-02","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"11","bibliographicPageStart":"e13689","bibliographicVolumeNumber":"31","bibliographic_titles":[{"bibliographic_title":"Neurogastroenterology & Motility","bibliographic_titleLang":"en"}]}]},"item_10001_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Background: The traditional Japanese herbal medicine, daikenchuto (DKT), has been used to treat constipation and postoperative ileus. However, the precise mechanisms involved in the pharmacological effects of DKT remain uncertain. The aim of this study was to clarify the effect of DKT on motor patterns and transit activity in the isolated rat colon.\nMethods: The entire colon or segments of the proximal colon in rats were isolated and placed in Krebs solution. The motility of the colon was evaluated by analyzing spatiotemporal maps of diameter derived from video imaging and measuring the intraluminal pressure in the anal end of the proximal colon, and the transit time of a plastic bead through the entire isolated colon.\nKey Results: Several types of propagating contractions were observed in the isolated entire colon. When DKT was added to Krebs solution, the frequency of large‐extent anal propagating contractions increased. DKT treatment increased the intraluminal pressure in the isolated proximal colon, which was related to the propagating contractions. This effect was abolished by treatment with the neural blocker tetrodotoxin. These findings suggest DKT induced peristaltic contractions in the isolated colon. DKT accelerated colonic transit activity, which was related to peristaltic contractions induction in the colon. These effects were also observed in the colons treated with bethanechol and the active ingredient of DKT, hydroxy‐α‐sanshool.\nConclusions and Inferences: Daikenchuto could enhance colonic transit activity by inducing peristaltic contractions, which may be mediated by the activation of the enteric nervous system in the colon.","subitem_description_language":"en","subitem_description_type":"Abstract"}]},"item_10001_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"John Wiley & Sons","subitem_publisher_language":"en"}]},"item_10001_rights_15":{"attribute_name":"権利情報","attribute_value_mlt":[{"subitem_rights":"This is an open access article under the terms of the Creative Commons Attribution‐NonCommercial License(https://creativecommons.org/licenses/by-nc/4.0/), which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.","subitem_rights_language":"en"}]},"item_10001_source_id_9":{"attribute_name":"収録物ID","attribute_value_mlt":[{"subitem_source_identifier":"13652982","subitem_source_identifier_type":"ISSN"},{"subitem_source_identifier":"AA11017929","subitem_source_identifier_type":"NCID"}]},"item_10001_version_type_20":{"attribute_name":"出版タイプ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_be7fb7dd8ff6fe43","subitem_version_type":"NA"}]},"item_1714461018643":{"attribute_name":"報告番号","attribute_value_mlt":[{"subitem_dissertationnumber":"甲第3504号"}]},"item_1714461102074":{"attribute_name":"学位名","attribute_value_mlt":[{"subitem_degreename":"博士（医学）","subitem_degreename_language":"ja"}]},"item_1714461118377":{"attribute_name":"学位授与年月日","attribute_value_mlt":[{"subitem_dategranted":"2021-03-23"}]},"item_1714461137393":{"attribute_name":"学位授与機関","attribute_value_mlt":[{"subitem_degreegrantor":[{"subitem_degreegrantor_language":"ja","subitem_degreegrantor_name":"徳島大学"}]}]},"item_1715043197608":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"open access"}]},"item_1718868208704":{"attribute_name":"備考","attribute_value_mlt":[{"subitem_textarea_language":"ja","subitem_textarea_value":"内容要旨・審査要旨・論文本文の公開\n本論文は，著者Kunitsugu Kubotaの学位論文として提出され，学位審査・授与の対象となっている。\n学位授与者所属 : 徳島大学大学院医科学教育部（医学専攻）"}]},"item_1718868303842":{"attribute_name":"学位記番号","attribute_value_mlt":[{"subitem_text_language":"ja","subitem_text_value":"甲医第1493号"}]},"item_1722929371688":{"attribute_name":"出版社版DOI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_language":"ja","subitem_relation_name_text":"10.1111/nmo.13689"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://doi.org/10.1111/nmo.13689","subitem_relation_type_select":"DOI"}}]},"item_1723180141928":{"attribute_name":"EID","attribute_value_mlt":[{"subitem_identifier_type":"URI","subitem_identifier_uri":"367227"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"久保田, 訓世","creatorNameLang":"ja"},{"creatorName":"クボタ, クニツグ","creatorNameLang":"ja-Kana"},{"creatorName":"Kubota, Kunitsugu","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"マセ, アキヒト","creatorNameLang":"ja"},{"creatorName":"マセ, アキヒト","creatorNameLang":"ja-Kana"},{"creatorName":"Mase, Akihito","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"マツシマ, ヒロアキ","creatorNameLang":"ja"},{"creatorName":"マツシマ, ヒロアキ","creatorNameLang":"ja-Kana"},{"creatorName":"Matsushima, Hiroaki","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"フジツカ, ナオキ","creatorNameLang":"ja"},{"creatorName":"フジツカ, ナオキ","creatorNameLang":"ja-Kana"},{"creatorName":"Fujitsuka, Naoki","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"ヤマモト, マサヒロ","creatorNameLang":"ja"},{"creatorName":"ヤマモト, マサヒロ","creatorNameLang":"ja-Kana"},{"creatorName":"Yamamoto, Masahiro","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"森根, 裕二","creatorNameLang":"ja"}],"nameIdentifiers":[{"nameIdentifier":"193","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"タケトミ, アキノブ","creatorNameLang":"ja"},{"creatorName":"タケトミ, アキノブ","creatorNameLang":"ja-Kana"},{"creatorName":"Taketomi, Akinobu","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"コウノ, トオル","creatorNameLang":"ja"},{"creatorName":"コウノ, トオル","creatorNameLang":"ja-Kana"},{"creatorName":"Kono, Toru","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"島田, 光生","creatorNameLang":"ja"}],"nameIdentifiers":[{"nameIdentifier":"1253","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_access","date":[{"dateType":"Available","dateValue":"2021-06-15"}],"displaytype":"detail","filename":"k3504_abstract_review.pdf","filesize":[{"value":"278 KB"}],"format":"application/pdf","mimetype":"application/pdf","url":{"objectType":"abstract","url":"https://tokushima-u.repo.nii.ac.jp/record/2008571/files/k3504_abstract_review.pdf"},"version_id":"e3e7846a-b48d-4512-9479-3dfe6fe551d9"},{"accessrole":"open_access","date":[{"dateType":"Available","dateValue":"2021-06-15"}],"displaytype":"detail","filename":"k3504_fulltext.pdf","filesize":[{"value":"1.29 MB"}],"format":"application/pdf","mimetype":"application/pdf","url":{"objectType":"fulltext","url":"https://tokushima-u.repo.nii.ac.jp/record/2008571/files/k3504_fulltext.pdf"},"version_id":"91f10542-591a-4566-a434-2ed9452d8f3f"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"Colon","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"daikenchuto","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"hydroxy‐α‐sanshool","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"peristaltic contraction","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"postoperative ileus","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"doctoral thesis","resourceuri":"http://purl.org/coar/resource_type/c_db06"}]},"item_title":"Daikenchuto, a traditional Japanese herbal medicine, promotes colonic transit by inducing a propulsive movement pattern","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Daikenchuto, a traditional Japanese herbal medicine, promotes colonic transit by inducing a propulsive movement pattern","subitem_title_language":"en"}]},"item_type_id":"40001","owner":"7","path":["1716268551628"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2021-06-15"},"publish_date":"2021-06-15","publish_status":"0","recid":"2008571","relation_version_is_last":true,"title":["Daikenchuto, a traditional Japanese herbal medicine, promotes colonic transit by inducing a propulsive movement pattern"],"weko_creator_id":"7","weko_shared_id":-1},"updated":"2024-11-22T07:25:11.188872+00:00"}