{"created":"2024-11-22T07:25:37.713718+00:00","id":2008578,"links":{},"metadata":{"_buckets":{"deposit":"39a5b217-222c-4236-8386-edc32ad3b63e"},"_deposit":{"created_by":7,"id":"2008578","owners":[7],"pid":{"revision_id":0,"type":"depid","value":"2008578"},"status":"published"},"_oai":{"id":"oai:tokushima-u.repo.nii.ac.jp:02008578","sets":["1713853213384:1713853295607"]},"author_link":["306","1533"],"control_number":"2008578","item_10001_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2019-11-26","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"1","bibliographicPageEnd":"51","bibliographicPageStart":"46","bibliographicVolumeNumber":"40","bibliographic_titles":[{"bibliographic_title":"Neuropsychopharmacology Reports","bibliographic_titleLang":"en"}]}]},"item_10001_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Background: Lithium is the first‐line drug for the treatment of bipolar disorders (BDs); however, not all patients responded. Glycogen synthase kinase (GSK) 3β and brain‐derived neurotrophic factor (BDNF) play a role in the therapeutic action of lithium. Since structural variations were reported in these genes, it is possible that these genomic variations may be involved in the therapeutic responses to lithium.\nMethod: Fifty patients with BDs and 50 healthy subjects (mean age 55.0 ± 15.0 years; M/F 19/31) participated. We examined structural variation of the GSK3β and BDNF genes by real‐time PCR. We examined the influence of structural variation of these genes on the therapeutic responses to lithium and the occurrence of antidepressant‐emergent affective switch (AEAS). The efficacy of lithium was assessed using the Alda scale, and AEAS was evaluated using Young Mania Rating Scale.\nResults: Although we examined structural variations within intron II and VII of the GSK3® gene and from the end of exon IV to intron IV and within exon IX of the BDNF gene, no structural variation was found in BDs. Whereas 5 of 50 patients exhibited three copies of the genomic region within exon IV of the BDNF gene, all healthy subjects had two copies. No difference in the therapeutic efficacy of lithium was found between patients with three and two copies. No difference in the occurrence of AEAS was found between the two groups.\nConclusion: The amplification of the BDNF gene influenced neither the therapeutic responses to lithium nor the occurrence of AEAS.","subitem_description_language":"en","subitem_description_type":"Abstract"}]},"item_10001_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"The Japanese Society of Neuropsychopharmacology","subitem_publisher_language":"en"},{"subitem_publisher":"John Wiley & Sons","subitem_publisher_language":"en"}]},"item_10001_rights_15":{"attribute_name":"権利情報","attribute_value_mlt":[{"subitem_rights":"This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.","subitem_rights_language":"en"}]},"item_10001_source_id_9":{"attribute_name":"収録物ID","attribute_value_mlt":[{"subitem_source_identifier":"2574173X","subitem_source_identifier_type":"ISSN"}]},"item_10001_version_type_20":{"attribute_name":"出版タイプ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_1715043197608":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"open access"}]},"item_1718868208704":{"attribute_name":"備考","attribute_value_mlt":[{"subitem_textarea_language":"ja","subitem_textarea_value":"所属英表記誤記あり　(誤)Watarigawa Hostipal→(正)Watarigawa Hospital"}]},"item_1722929371688":{"attribute_name":"出版社版DOI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_language":"ja","subitem_relation_name_text":"10.1002/npr2.12083"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://doi.org/10.1002/npr2.12083","subitem_relation_type_select":"DOI"}}]},"item_1723180141928":{"attribute_name":"EID","attribute_value_mlt":[{"subitem_identifier_type":"URI","subitem_identifier_uri":"361876"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"スガ, ヨウスケ","creatorNameLang":"ja"},{"creatorName":"スガ, ヨウスケ","creatorNameLang":"ja-Kana"},{"creatorName":"Suga, Yosuke","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"ヨシモト, ケイイチロウ","creatorNameLang":"ja"},{"creatorName":"ヨシモト, ケイイチロウ","creatorNameLang":"ja-Kana"},{"creatorName":"Yoshimoto, Keiichiro","creatorNameLang":"en"}]},{"creatorAffiliations":[{"affiliationNameIdentifiers":[{"affiliationNameIdentifier":"","affiliationNameIdentifierScheme":"ISNI","affiliationNameIdentifierURI":"http://www.isni.org/isni/"}],"affiliationNames":[{"affiliationName":"","affiliationNameLang":"ja"}]}],"creatorNames":[{"creatorName":"沼田, 周助","creatorNameLang":"ja"},{"creatorName":"ヌマタ, シュウスケ","creatorNameLang":"ja-Kana"},{"creatorName":"Numata, Shusuke","creatorNameLang":"en"}],"familyNames":[{"familyName":"沼田","familyNameLang":"ja"},{"familyName":"ヌマタ","familyNameLang":"ja-Kana"},{"familyName":"Numata","familyNameLang":"en"}],"givenNames":[{"givenName":"周助","givenNameLang":"ja"},{"givenName":"シュウスケ","givenNameLang":"ja-Kana"},{"givenName":"Shusuke","givenNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"306","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"172447/profile-ja.html","nameIdentifierScheme":"徳島大学 教育研究者総覧","nameIdentifierURI":"http://pub2.db.tokushima-u.ac.jp/ERD/person/172447/profile-ja.html"},{"nameIdentifier":"10403726","nameIdentifierScheme":"e-Rad","nameIdentifierURI":"https://nrid.nii.ac.jp/ja/search/?qm=10403726"}]},{"creatorNames":[{"creatorName":"シモデラ, シンジ","creatorNameLang":"ja"},{"creatorName":"シモデラ, シンジ","creatorNameLang":"ja-Kana"},{"creatorName":"Shimodera, Shinji","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"タカムラ, ショウゴ","creatorNameLang":"ja"},{"creatorName":"タカムラ, ショウゴ","creatorNameLang":"ja-Kana"},{"creatorName":"Takamura, Shogo","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"カミムラ, ナオト","creatorNameLang":"ja"},{"creatorName":"カミムラ, ナオト","creatorNameLang":"ja-Kana"},{"creatorName":"Kamimura, Naoto","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"サワダ, ケン","creatorNameLang":"ja"},{"creatorName":"サワダ, ケン","creatorNameLang":"ja-Kana"},{"creatorName":"Sawada, Ken","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"カズイ, ヒロミツ","creatorNameLang":"ja"},{"creatorName":"カズイ, ヒロミツ","creatorNameLang":"ja-Kana"},{"creatorName":"Kazui, Hiromitsu","creatorNameLang":"en"}]},{"creatorAffiliations":[{"affiliationNameIdentifiers":[{"affiliationNameIdentifier":"","affiliationNameIdentifierScheme":"ISNI","affiliationNameIdentifierURI":"http://www.isni.org/isni/"}],"affiliationNames":[{"affiliationName":"","affiliationNameLang":"ja"}]}],"creatorNames":[{"creatorName":"大森, 哲郎","creatorNameLang":"ja"},{"creatorName":"オオモリ, テツロウ","creatorNameLang":"ja-Kana"},{"creatorName":"Ohmori, Tetsuro","creatorNameLang":"en"}],"familyNames":[{"familyName":"大森","familyNameLang":"ja"},{"familyName":"オオモリ","familyNameLang":"ja-Kana"},{"familyName":"Ohmori","familyNameLang":"en"}],"givenNames":[{"givenName":"哲郎","givenNameLang":"ja"},{"givenName":"テツロウ","givenNameLang":"ja-Kana"},{"givenName":"Tetsuro","givenNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"1533","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"60046/profile-ja.html","nameIdentifierScheme":"徳島大学 教育研究者総覧","nameIdentifierURI":"http://pub2.db.tokushima-u.ac.jp/ERD/person/60046/profile-ja.html"},{"nameIdentifier":"00221135","nameIdentifierScheme":"e-Rad","nameIdentifierURI":"https://nrid.nii.ac.jp/ja/search/?qm=00221135"}]},{"creatorNames":[{"creatorName":"モリノブ, シゲル","creatorNameLang":"ja"},{"creatorName":"モリノブ, シゲル","creatorNameLang":"ja-Kana"},{"creatorName":"Morinobu, Shigeru","creatorNameLang":"en"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_access","date":[{"dateType":"Available","dateValue":"2021-04-20"}],"displaytype":"detail","filename":"npr_40_1_46.pdf","filesize":[{"value":"492 KB"}],"format":"application/pdf","licensetype":"license_0","mimetype":"application/pdf","url":{"objectType":"fulltext","url":"https://tokushima-u.repo.nii.ac.jp/record/2008578/files/npr_40_1_46.pdf"},"version_id":"f18f887f-c831-45dc-acd0-32e7723933bb"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"bipolar disorder","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"brain‐derived neurotrophic factor","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"copy number variation","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"glycogen synthase kinase 3®","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"lithium","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Structural variation in the glycogen synthase kinase 3β and brain‐derived neurotrophic factor genes in Japanese patients with bipolar disorders","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Structural variation in the glycogen synthase kinase 3β and brain‐derived neurotrophic factor genes in Japanese patients with bipolar disorders","subitem_title_language":"en"}]},"item_type_id":"40001","owner":"7","path":["1713853295607"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2021-04-20"},"publish_date":"2021-04-20","publish_status":"0","recid":"2008578","relation_version_is_last":true,"title":["Structural variation in the glycogen synthase kinase 3β and brain‐derived neurotrophic factor genes in Japanese patients with bipolar disorders"],"weko_creator_id":"7","weko_shared_id":-1},"updated":"2025-02-12T00:18:32.657347+00:00"}