{"created":"2024-11-22T07:25:43.361308+00:00","id":2008579,"links":{},"metadata":{"_buckets":{"deposit":"5d0f7e96-7fe3-40c3-a4fa-da020ec61369"},"_deposit":{"created_by":7,"id":"2008579","owners":[7],"pid":{"revision_id":0,"type":"depid","value":"2008579"},"status":"published"},"_oai":{"id":"oai:tokushima-u.repo.nii.ac.jp:02008579","sets":["1713853213384:1713853295607"]},"author_link":["306","1533"],"control_number":"2008579","item_10001_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2020-02-05","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"2","bibliographicPageEnd":"156","bibliographicPageStart":"150","bibliographicVolumeNumber":"40","bibliographic_titles":[{"bibliographic_title":"Neuropsychopharmacology Reports","bibliographic_titleLang":"en"}]}]},"item_10001_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Aim: Matrix metalloproteinase‐9 (MMP‐9) has been shown to modulate synaptic plasticity and may contribute to the pathophysiology of schizophrenia. This study investigated the peripheral levels of MMP‐9 and its association with cognitive functions in patients with schizophrenia to see the possible involvement of MMP‐9 in pathophysiology of schizophrenia, especially in cognitive decline.\nMethods: We measured the plasma levels of MMP‐9 in 257 healthy controls and 249 patients with schizophrenia, including antipsychotic drug–free patients. We also explored the possible association between plasma MMP‐9 levels and cognitive performance in healthy controls and patients with schizophrenia using the Wechsler Adult Intelligence Scale, Third Edition (WAIS‐ III), the Wechsler Memory Scale‐Revised (WMS‐R), and the Rey Auditory Verbal Learning Test (AVLT).\nResults: We found that the plasma levels of MMP‐9 were significantly higher in patients with schizophrenia, including antipsychotic drug–free patients, than in healthy controls. We found a significant negative association between plasma MMP‐9 levels and cognitive performance in controls and patients with schizophrenia.\nConclusion: Together, these convergent data suggest a possible biological mechanism for schizophrenia, whereby increased MMP‐9 levels are associated with cognitive impairment.","subitem_description_language":"en","subitem_description_type":"Abstract"}]},"item_10001_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"The Japanese Society of Neuropsychopharmacology","subitem_publisher_language":"en"},{"subitem_publisher":"John Wiley & Sons","subitem_publisher_language":"en"}]},"item_10001_rights_15":{"attribute_name":"権利情報","attribute_value_mlt":[{"subitem_rights":"This is an open access article under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.","subitem_rights_language":"en"}]},"item_10001_source_id_9":{"attribute_name":"収録物ID","attribute_value_mlt":[{"subitem_source_identifier":"2574173X","subitem_source_identifier_type":"ISSN"}]},"item_10001_version_type_20":{"attribute_name":"出版タイプ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_1715043197608":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"open access"}]},"item_1722929371688":{"attribute_name":"出版社版DOI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_language":"ja","subitem_relation_name_text":"10.1002/npr2.12098"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://doi.org/10.1002/npr2.12098","subitem_relation_type_select":"DOI"}}]},"item_1723180141928":{"attribute_name":"EID","attribute_value_mlt":[{"subitem_identifier_type":"URI","subitem_identifier_uri":"365486"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"クドウ, ノリコ","creatorNameLang":"ja"},{"creatorName":"クドウ, ノリコ","creatorNameLang":"ja-Kana"},{"creatorName":"Kudo, Noriko","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"ヤマモリ, ヒデナガ","creatorNameLang":"ja"},{"creatorName":"ヤマモリ, ヒデナガ","creatorNameLang":"ja-Kana"},{"creatorName":"Yamamori, Hidenaga","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"イシマ, タマキ","creatorNameLang":"ja"},{"creatorName":"イシマ, タマキ","creatorNameLang":"ja-Kana"},{"creatorName":"Ishima, Tamaki","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"ネモト, キヨタカ","creatorNameLang":"ja"},{"creatorName":"ネモト, キヨタカ","creatorNameLang":"ja-Kana"},{"creatorName":"Nemoto, Kiyotaka","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"ヤスダ, ユカ","creatorNameLang":"ja"},{"creatorName":"ヤスダ, ユカ","creatorNameLang":"ja-Kana"},{"creatorName":"Yasuda, Yuka","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"フジモト, ミチコ","creatorNameLang":"ja"},{"creatorName":"フジモト, ミチコ","creatorNameLang":"ja-Kana"},{"creatorName":"Fujimoto, Michiko","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"アゼチ, ヒロツグ","creatorNameLang":"ja"},{"creatorName":"アゼチ, ヒロツグ","creatorNameLang":"ja-Kana"},{"creatorName":"Azechi, Hirotsugu","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"ニイツ, トミヒサ","creatorNameLang":"ja"},{"creatorName":"ニイツ, 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Tetsuro","creatorNameLang":"en"}],"familyNames":[{"familyName":"大森","familyNameLang":"ja"},{"familyName":"オオモリ","familyNameLang":"ja-Kana"},{"familyName":"Ohmori","familyNameLang":"en"}],"givenNames":[{"givenName":"哲郎","givenNameLang":"ja"},{"givenName":"テツロウ","givenNameLang":"ja-Kana"},{"givenName":"Tetsuro","givenNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"1533","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"60046/profile-ja.html","nameIdentifierScheme":"徳島大学 教育研究者総覧","nameIdentifierURI":"http://pub2.db.tokushima-u.ac.jp/ERD/person/60046/profile-ja.html"},{"nameIdentifier":"00221135","nameIdentifierScheme":"e-Rad","nameIdentifierURI":"https://nrid.nii.ac.jp/ja/search/?qm=00221135"}]},{"creatorNames":[{"creatorName":"フクナガ, マサキ","creatorNameLang":"ja"},{"creatorName":"フクナガ, マサキ","creatorNameLang":"ja-Kana"},{"creatorName":"Fukunaga, Masaki","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"ワタナベ, ヨシユキ","creatorNameLang":"ja"},{"creatorName":"ワタナベ, ヨシユキ","creatorNameLang":"ja-Kana"},{"creatorName":"Watanabe, Yoshiyuki","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"ハシモト, ケンジ","creatorNameLang":"ja"},{"creatorName":"ハシモト, ケンジ","creatorNameLang":"ja-Kana"},{"creatorName":"Hashimoto, Kenji","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"ハシモト, リョウタ","creatorNameLang":"ja"},{"creatorName":"ハシモト, リョウタ","creatorNameLang":"ja-Kana"},{"creatorName":"Hashimoto, Ryota","creatorNameLang":"en"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_access","date":[{"dateType":"Available","dateValue":"2021-04-20"}],"displaytype":"detail","filename":"npr_40_2_150.pdf","filesize":[{"value":"428 KB"}],"format":"application/pdf","licensetype":"license_5","mimetype":"application/pdf","url":{"objectType":"fulltext","url":"https://tokushima-u.repo.nii.ac.jp/record/2008579/files/npr_40_2_150.pdf"},"version_id":"d0dfbc50-8430-4760-9c05-f0767724f9c1"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"cognitive performance","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"matrix metalloproteinase-9","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"schizophrenia","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Wechsler Adult Intelligence Scale","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Wechsler Memory Scale","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Plasma levels of matrix metalloproteinase‐9 (MMP‐9) are associated with cognitive performance in patients with schizophrenia","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Plasma levels of matrix metalloproteinase‐9 (MMP‐9) are associated with cognitive performance in patients with schizophrenia","subitem_title_language":"en"}]},"item_type_id":"40001","owner":"7","path":["1713853295607"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2021-04-20"},"publish_date":"2021-04-20","publish_status":"0","recid":"2008579","relation_version_is_last":true,"title":["Plasma levels of matrix metalloproteinase‐9 (MMP‐9) are associated with cognitive performance in patients with schizophrenia"],"weko_creator_id":"7","weko_shared_id":-1},"updated":"2025-02-12T00:18:32.927048+00:00"}