{"created":"2024-11-22T07:26:52.546785+00:00","id":2008591,"links":{},"metadata":{"_buckets":{"deposit":"2db21b5c-fda8-40fc-9760-3d8ab82bb8ad"},"_deposit":{"created_by":7,"id":"2008591","owners":[7],"pid":{"revision_id":0,"type":"depid","value":"2008591"},"status":"published"},"_oai":{"id":"oai:tokushima-u.repo.nii.ac.jp:02008591","sets":["1713853213384:1713853295607"]},"author_link":["900"],"control_number":"2008591","item_10001_alternative_title_1":{"attribute_name":"タイトル別表記","attribute_value_mlt":[{"subitem_alternative_title":"SBRT FOR CENTRAL LUNG TUMORS WITH 56 Gy/7 fr","subitem_alternative_title_language":"en"}]},"item_10001_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2018-07-23","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"4","bibliographicPageEnd":"4506","bibliographicPageStart":"4498","bibliographicVolumeNumber":"16","bibliographic_titles":[{"bibliographic_title":"Oncology Letters","bibliographic_titleLang":"en"}]}]},"item_10001_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Stereotactic body radiotherapy (SBRT) for centrally‑located lung tumors remains a challenge because of the increased risk of treatment‑related adverse events (AEs), and uncertainty around prescribing the optimal dose. The present study reported the results of central tumor SBRT with 56 Gy in 7 fractions (fr) at the University of Tokyo Hospital. A total of 35 cases that underwent SBRT with or without volumetric‑modulated arc therapy consisting of 56 Gy/7 fr for central lung lesions between 2010 and 2016 at the University of Tokyo Hospital were reveiwed. A central lesion was defined as a tumor within 2 cm of the proximal bronchial tree (RTOG 0236 definition) or within 2 cm in all directions of any critical mediastinal structure. Local control (LC), overall survival (OS), and AEs were investigated. The Kaplan‑Meier method was used to estimate LC and OS. AEs were scored per the Common Terminology Criteria for Adverse Events Version 4.0. Thirty‑five patients with 36 central lung lesions were included. Fifteen lesions were primary non‑small cell lung cancer (NSCLC), 13 were recurrences of NSCLC, and 8 had oligo‑recurrences from other primaries. Median tumor diameter was 29 mm. Eighteen patients had had prior surgery. At a median follow‑up of 13.1 months for all patients and 18.3 months in surviving patients, 22 patients had died, ten due to primary disease (4 NSCLC), while three were treatment‑related. The 1‑ and 2‑year OS were 57.3 and 40.4%, respectively, and median OS was 15.7 months. Local recurrence occurred in only two lesions. 1‑ and 2‑year LC rates were both 96%. Nine patients experienced grade ≥3 toxicity, representing 26% of the cohort. Two of these were grade 5, one pneumonitis and one hemoptysis. Considering the background of the subject, tumor control of our central SBRT is promising, especially in primary NSCLC. However, the safety of SBRT to central lung cancer remains controversial.","subitem_description_language":"en","subitem_description_type":"Abstract"}]},"item_10001_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Spandidos Publications","subitem_publisher_language":"en"}]},"item_10001_rights_15":{"attribute_name":"権利情報","attribute_value_mlt":[{"subitem_rights":"This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0) License.","subitem_rights_language":"en"}]},"item_10001_source_id_9":{"attribute_name":"収録物ID","attribute_value_mlt":[{"subitem_source_identifier":"17921074","subitem_source_identifier_type":"ISSN"},{"subitem_source_identifier":"17921082","subitem_source_identifier_type":"ISSN"}]},"item_10001_version_type_20":{"attribute_name":"出版タイプ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_1715043197608":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"open access"}]},"item_1722929371688":{"attribute_name":"出版社版DOI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_language":"ja","subitem_relation_name_text":"10.3892/ol.2018.9188"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://doi.org/10.3892/ol.2018.9188","subitem_relation_type_select":"DOI"}}]},"item_1723180141928":{"attribute_name":"EID","attribute_value_mlt":[{"subitem_identifier_type":"URI","subitem_identifier_uri":"345645"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"アオキ, シュリ","creatorNameLang":"ja"},{"creatorName":"アオキ, シュリ","creatorNameLang":"ja-Kana"},{"creatorName":"Aoki, Shuri","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"ヤマシタ, ヒデオミ","creatorNameLang":"ja"},{"creatorName":"ヤマシタ, ヒデオミ","creatorNameLang":"ja-Kana"},{"creatorName":"Yamashita, Hideomi","creatorNameLang":"en"}]},{"creatorAffiliations":[{"affiliationNameIdentifiers":[{"affiliationNameIdentifier":"","affiliationNameIdentifierScheme":"ISNI","affiliationNameIdentifierURI":"http://www.isni.org/isni/"}],"affiliationNames":[{"affiliationName":"","affiliationNameLang":"ja"}]}],"creatorNames":[{"creatorName":"芳賀, 昭弘","creatorNameLang":"ja"},{"creatorName":"ハガ, アキヒロ","creatorNameLang":"ja-Kana"},{"creatorName":"Haga, Akihiro","creatorNameLang":"en"}],"familyNames":[{"familyName":"芳賀","familyNameLang":"ja"},{"familyName":"ハガ","familyNameLang":"ja-Kana"},{"familyName":"Haga","familyNameLang":"en"}],"givenNames":[{"givenName":"昭弘","givenNameLang":"ja"},{"givenName":"アキヒロ","givenNameLang":"ja-Kana"},{"givenName":"Akihiro","givenNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"900","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"334008/profile-ja.html","nameIdentifierScheme":"徳島大学 教育研究者総覧","nameIdentifierURI":"http://pub2.db.tokushima-u.ac.jp/ERD/person/334008/profile-ja.html"}]},{"creatorNames":[{"creatorName":"オオタ, タケシ","creatorNameLang":"ja"},{"creatorName":"オオタ, タケシ","creatorNameLang":"ja-Kana"},{"creatorName":"Ota, Takeshi","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"タカハシ, ワタル","creatorNameLang":"ja"},{"creatorName":"タカハシ, ワタル","creatorNameLang":"ja-Kana"},{"creatorName":"Takahashi, Wataru","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"オザキ, ショウ","creatorNameLang":"ja"},{"creatorName":"オザキ, ショウ","creatorNameLang":"ja-Kana"},{"creatorName":"Ozaki, Sho","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"ナワ, カナブ","creatorNameLang":"ja"},{"creatorName":"ナワ, カナブ","creatorNameLang":"ja-Kana"},{"creatorName":"Nawa, Kanabu","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"イマエ, トシカズ","creatorNameLang":"ja"},{"creatorName":"イマエ, トシカズ","creatorNameLang":"ja-Kana"},{"creatorName":"Imae, Toshikazu","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"アベ, オサム","creatorNameLang":"ja"},{"creatorName":"アベ, オサム","creatorNameLang":"ja-Kana"},{"creatorName":"Abe, Osamu","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"ナカガワ, ケイイチ","creatorNameLang":"ja"},{"creatorName":"ナカガワ, ケイイチ","creatorNameLang":"ja-Kana"},{"creatorName":"Nakagawa, Keiichi","creatorNameLang":"en"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_access","date":[{"dateType":"Available","dateValue":"2021-07-09"}],"displaytype":"detail","filename":"ol_16_4_4498.pdf","filesize":[{"value":"991 KB"}],"format":"application/pdf","licensetype":"license_5","mimetype":"application/pdf","url":{"objectType":"fulltext","url":"https://tokushima-u.repo.nii.ac.jp/record/2008591/files/ol_16_4_4498.pdf"},"version_id":"06f763da-1d4a-4025-985a-631546356a17"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"central lung tumor","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"stereotactic body radiotherapy","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"volumetric modulated arc therapy","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"lung cancer","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"radiation pneumonitis","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"pulmonary oligo‑recurrence","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Stereotactic body radiotherapy for centrally‑located lung tumors with 56 Gy in seven fractions : A retrospective study","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Stereotactic body radiotherapy for centrally‑located lung tumors with 56 Gy in seven fractions : A retrospective study","subitem_title_language":"en"}]},"item_type_id":"40001","owner":"7","path":["1713853295607"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2021-07-09"},"publish_date":"2021-07-09","publish_status":"0","recid":"2008591","relation_version_is_last":true,"title":["Stereotactic body radiotherapy for centrally‑located lung tumors with 56 Gy in seven fractions : A retrospective study"],"weko_creator_id":"7","weko_shared_id":-1},"updated":"2025-01-29T13:15:34.198899+00:00"}