{"created":"2024-11-22T07:30:39.122175+00:00","id":2008631,"links":{},"metadata":{"_buckets":{"deposit":"b572b577-a36e-4929-b19c-4eb6789212fa"},"_deposit":{"created_by":7,"id":"2008631","owners":[7],"pid":{"revision_id":0,"type":"depid","value":"2008631"},"status":"published"},"_oai":{"id":"oai:tokushima-u.repo.nii.ac.jp:02008631","sets":["1713853213384:1713853295607"]},"author_link":["1643","1253"],"control_number":"2008631","item_10001_alternative_title_1":{"attribute_name":"タイトル別表記","attribute_value_mlt":[{"subitem_alternative_title":"NCRT with S-1 plus irinotecan for LALRC","subitem_alternative_title_language":"en"}]},"item_10001_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2016-06-14","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"2","bibliographicPageEnd":"227","bibliographicPageStart":"222","bibliographicVolumeNumber":"120","bibliographic_titles":[{"bibliographic_title":"Radiotherapy and Oncology","bibliographic_titleLang":"en"}]}]},"item_10001_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Background and purpose: Preoperative 5-fluorouracil-based chemoradiotherapy is a standard treatment for locally advanced lower rectal cancer (LALRC). We performed a phase I study to develop a new regimen combining irinotecan and S-1.\nMaterials and methods: Patients with LALRC (T3-4, N0-2) were studied. The radiation dose was 45 Gy in 25 fractions. S-1 (80 mg/m2/day) was administered on days 1–5, 8–12, 22–26, and 29–33. Irinotecan was administered on days 1, 8, 22, and 29. The dose of irinotecan was initially 60 mg/m2 (level 1). Surgery was performed 6–10 weeks after the chemoradiotherapy.\nResults: Twenty patients were enrolled, of whom 18 patients were analyzed. Dose-limiting toxicity (DLT) did not occur in the first 3 patients treated with irinotecan at 80 mg/m2 (level 2), but developed in 3 of the 6 patients who received irinotecan at 90 mg/m2 (level 3). Then DLT occurred in 3 other patients at level 2. At level 2 or 3, DLT comprised neutropenia, thrombocytopenia, and diarrhea. Level 2 was designated as the maximum tolerated dose, and level 1 as a recommended dose (RD). The pathological complete response rate was 28%, and the down-staging rate was 56%.\nConclusions: Our results suggested that the RD of irinotecan when combined with preoperative S-1 and pelvic radiation was 60 mg/m2.","subitem_description_language":"en","subitem_description_type":"Abstract"}]},"item_10001_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Elsevier","subitem_publisher_language":"en"}]},"item_10001_rights_15":{"attribute_name":"権利情報","attribute_value_mlt":[{"subitem_rights":"This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).","subitem_rights_language":"en"}]},"item_10001_source_id_9":{"attribute_name":"収録物ID","attribute_value_mlt":[{"subitem_source_identifier":"01678140","subitem_source_identifier_type":"ISSN"},{"subitem_source_identifier":"AA10476884","subitem_source_identifier_type":"NCID"},{"subitem_source_identifier":"AA11538852","subitem_source_identifier_type":"NCID"}]},"item_10001_version_type_20":{"attribute_name":"出版タイプ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_1715043197608":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"open access"}]},"item_1722929371688":{"attribute_name":"出版社版DOI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_language":"ja","subitem_relation_name_text":"10.1016/j.radonc.2016.06.002"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://doi.org/10.1016/j.radonc.2016.06.002","subitem_relation_type_select":"DOI"}}]},"item_1723180141928":{"attribute_name":"EID","attribute_value_mlt":[{"subitem_identifier_type":"URI","subitem_identifier_uri":"321157"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"サトウ, タケオ","creatorNameLang":"ja"},{"creatorName":"サトウ, タケオ","creatorNameLang":"ja-Kana"},{"creatorName":"Sato, Takeo","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"ハヤカワ, カズシゲ","creatorNameLang":"ja"},{"creatorName":"ハヤカワ, カズシゲ","creatorNameLang":"ja-Kana"},{"creatorName":"Hayakawa, Kazushige","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"トミタ, 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Mitsuo","creatorNameLang":"en"}],"familyNames":[{"familyName":"島田","familyNameLang":"ja"},{"familyName":"シマダ","familyNameLang":"ja-Kana"},{"familyName":"Shimada","familyNameLang":"en"}],"givenNames":[{"givenName":"光生","givenNameLang":"ja"},{"givenName":"ミツオ","givenNameLang":"ja-Kana"},{"givenName":"Mitsuo","givenNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"1253","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"82712/profile-ja.html","nameIdentifierScheme":"徳島大学 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Hitoshi","creatorNameLang":"en"}],"familyNames":[{"familyName":"生島","familyNameLang":"ja"},{"familyName":"イクシマ","familyNameLang":"ja-Kana"},{"familyName":"Ikushima","familyNameLang":"en"}],"givenNames":[{"givenName":"仁史","givenNameLang":"ja"},{"givenName":"ヒトシ","givenNameLang":"ja-Kana"},{"givenName":"Hitoshi","givenNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"1643","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"60299/profile-ja.html","nameIdentifierScheme":"徳島大学 教育研究者総覧","nameIdentifierURI":"http://pub2.db.tokushima-u.ac.jp/ERD/person/60299/profile-ja.html"},{"nameIdentifier":"90202861","nameIdentifierScheme":"e-Rad","nameIdentifierURI":"https://nrid.nii.ac.jp/ja/search/?qm=90202861"}]},{"creatorNames":[{"creatorName":"ババ, ヒデオ","creatorNameLang":"ja"},{"creatorName":"ババ, ヒデオ","creatorNameLang":"ja-Kana"},{"creatorName":"Baba, Hideo","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"オオヤ, ナツオ","creatorNameLang":"ja"},{"creatorName":"オオヤ, 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Masahiko","creatorNameLang":"en"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_access","date":[{"dateType":"Available","dateValue":"2021-04-28"}],"displaytype":"detail","filename":"radonc_120_2_222.pdf","filesize":[{"value":"707 KB"}],"format":"application/pdf","licensetype":"license_5","mimetype":"application/pdf","url":{"objectType":"fulltext","url":"https://tokushima-u.repo.nii.ac.jp/record/2008631/files/radonc_120_2_222.pdf"},"version_id":"20d6ff66-db16-49a3-acd7-54589e0ed5d8"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"Neoadjuvant chemoradiotherapy","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"S-1","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Irinotecan","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Rectal cancer","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"A multicenter phase I study of preoperative chemoradiotherapy with S-1 and irinotecan for locally advanced lower rectal cancer (SAMRAI-1)","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"A multicenter phase I study of preoperative chemoradiotherapy with S-1 and irinotecan for locally advanced lower rectal cancer (SAMRAI-1)","subitem_title_language":"en"}]},"item_type_id":"40001","owner":"7","path":["1713853295607"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2021-04-28"},"publish_date":"2021-04-28","publish_status":"0","recid":"2008631","relation_version_is_last":true,"title":["A multicenter phase I study of preoperative chemoradiotherapy with S-1 and irinotecan for locally advanced lower rectal cancer (SAMRAI-1)"],"weko_creator_id":"7","weko_shared_id":-1},"updated":"2025-01-29T00:16:25.977039+00:00"}