{"created":"2024-11-22T07:33:13.383907+00:00","id":2008659,"links":{},"metadata":{"_buckets":{"deposit":"fa1ac33e-6275-4fed-b6d5-2d713cd689a1"},"_deposit":{"created_by":7,"id":"2008659","owners":[7],"pid":{"revision_id":0,"type":"depid","value":"2008659"},"status":"published"},"_oai":{"id":"oai:tokushima-u.repo.nii.ac.jp:02008659","sets":["1713853213384:1713853295607"]},"author_link":["785"],"control_number":"2008659","item_10001_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2018-03-01","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"3","bibliographicPageEnd":"1074","bibliographicPageStart":"1059","bibliographicVolumeNumber":"10","bibliographic_titles":[{"bibliographic_title":"Stem Cell Reports","bibliographic_titleLang":"en"}]}]},"item_10001_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Increasing demand for clinical retinal degeneration therapies featuring human ESC/iPSC-derived retinal tissue and cells warrants proof-of-concept studies. Here, we established two mouse models of end-stage retinal degeneration with immunodeficiency, NOG-rd1-2J and NOG-rd10, and characterized disease progress and immunodeficient status. We also transplanted human ESC-derived retinal sheets into NOG-rd1-2J and confirmed their long-term survival and maturation of the structured graft photoreceptor layer, without rejection or tumorigenesis. We recorded light responses from the host ganglion cells using a multi-electrode array system; this result was consistent with whole-mount immunostaining suggestive of host-graft synapse formation at the responding sites. This study demonstrates an application of our mouse models and provides a proof of concept for the clinical use of human ESC-derived retinal sheets.","subitem_description_language":"en","subitem_description_type":"Abstract"}]},"item_10001_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"International Society for Stem Cell Research","subitem_publisher_language":"en"},{"subitem_publisher":"Cell Press","subitem_publisher_language":"en"}]},"item_10001_rights_15":{"attribute_name":"権利情報","attribute_value_mlt":[{"subitem_rights":"This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).","subitem_rights_language":"en"}]},"item_10001_source_id_9":{"attribute_name":"収録物ID","attribute_value_mlt":[{"subitem_source_identifier":"22136711","subitem_source_identifier_type":"ISSN"}]},"item_10001_version_type_20":{"attribute_name":"出版タイプ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_1715043197608":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"open access"}]},"item_1722929371688":{"attribute_name":"出版社版DOI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_language":"ja","subitem_relation_name_text":"10.1016/j.stemcr.2018.01.032"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://doi.org/10.1016/j.stemcr.2018.01.032","subitem_relation_type_select":"DOI"}}]},"item_1723180141928":{"attribute_name":"EID","attribute_value_mlt":[{"subitem_identifier_type":"URI","subitem_identifier_uri":"355254"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"イラハ, サトシ","creatorNameLang":"ja"},{"creatorName":"イラハ, サトシ","creatorNameLang":"ja-Kana"},{"creatorName":"Iraha, Satoshi","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Tu, Hung-Ya","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"ヤマサキ, スグル","creatorNameLang":"ja"},{"creatorName":"ヤマサキ, スグル","creatorNameLang":"ja-Kana"},{"creatorName":"Yamasaki, 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