{"created":"2024-11-22T07:39:02.300135+00:00","id":2008730,"links":{},"metadata":{"_buckets":{"deposit":"27a46014-b373-48a2-83cf-17acfafa25c2"},"_deposit":{"created_by":7,"id":"2008730","owners":[7],"pid":{"revision_id":0,"type":"depid","value":"2008730"},"status":"published"},"_oai":{"id":"oai:tokushima-u.repo.nii.ac.jp:02008730","sets":["1713853213384:1713853295607"]},"author_link":["897"],"control_number":"2008730","item_10001_alternative_title_1":{"attribute_name":"タイトル別表記","attribute_value_mlt":[{"subitem_alternative_title":"Low-Dose Intravenous Alteplase in Wake-Up Stroke","subitem_alternative_title_language":"en"}]},"item_10001_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2020-04-06","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"5","bibliographicPageEnd":"1538","bibliographicPageStart":"1530","bibliographicVolumeNumber":"51","bibliographic_titles":[{"bibliographic_title":"Stroke","bibliographic_titleLang":"en"}]}]},"item_10001_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Background and Purpose—We assessed whether lower-dose alteplase at 0.6 mg/kg is efficacious and safe for acute fluid-attenuated inversion recovery-negative stroke with unknown time of onset.\nMethods—This was an investigator-initiated, multicenter, randomized, open-label, blinded-end point trial. Patients met the standard indication criteria for intravenous thrombolysis other than a time last-known-well >4.5 hours (eg, wake-up stroke). Patients were randomly assigned (1:1) to receive alteplase at 0.6 mg/kg or standard medical treatment if magnetic resonance imaging showed acute ischemic lesion on diffusion-weighted imaging and no marked corresponding hyperintensity on fluid-attenuated inversion recovery. The primary outcome was a favorable outcome (90-day modified Rankin Scale score of 0–1).\nResults—Following the early stop and positive results of the WAKE-UP trial (Efficacy and Safety of MRI-Based Thrombolysis in Wake-Up Stroke), this trial was prematurely terminated with 131 of the anticipated 300 patients (55 women; mean age, 74.4±12.2 years). Favorable outcome was comparable between the alteplase group (32/68, 47.1%) and the control group (28/58, 48.3%; relative risk [RR], 0.97 [95% CI, 0.68–1.41]; P=0.892). Symptomatic intracranial hemorrhage within 22 to 36 hours occurred in 1/71 and 0/60 (RR, infinity [95% CI, 0.06 to infinity]; P>0.999), respectively. Death at 90 days occurred in 2/71 and 2/60 (RR, 0.85 [95% CI, 0.06–12.58]; P>0.999), respectively.\nConclusions—No difference in favorable outcome was seen between alteplase and control groups among patients with ischemic stroke with unknown time of onset. The safety of alteplase at 0.6 mg/kg was comparable to that of standard treatment. Early study termination precludes any definitive conclusions.","subitem_description_language":"en","subitem_description_type":"Abstract"}]},"item_10001_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"American Heart Association","subitem_publisher_language":"en"},{"subitem_publisher":"Wolters Kluwer Health","subitem_publisher_language":"en"}]},"item_10001_rights_15":{"attribute_name":"権利情報","attribute_value_mlt":[{"subitem_rights":"This is an open access article under the terms of the Creative Commons Attribution Non-Commercial-NoDerivs License, which permits use, distribution, and reproduction in any medium, provided that the original work is properly cited, the use is noncommercial, and no modifications or adaptations are made.","subitem_rights_language":"en"}]},"item_10001_source_id_9":{"attribute_name":"収録物ID","attribute_value_mlt":[{"subitem_source_identifier":"00392499","subitem_source_identifier_type":"ISSN"},{"subitem_source_identifier":"AA0085085X","subitem_source_identifier_type":"NCID"}]},"item_10001_version_type_20":{"attribute_name":"出版タイプ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_1715043197608":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"open access"}]},"item_1722929371688":{"attribute_name":"出版社版DOI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_language":"ja","subitem_relation_name_text":"10.1161/STROKEAHA.119.028127"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://doi.org/10.1161/STROKEAHA.119.028127","subitem_relation_type_select":"DOI"}}]},"item_1723180141928":{"attribute_name":"EID","attribute_value_mlt":[{"subitem_identifier_type":"URI","subitem_identifier_uri":"366209"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"コガ, マサトシ","creatorNameLang":"ja"},{"creatorName":"コガ, マサトシ","creatorNameLang":"ja-Kana"},{"creatorName":"Koga, Masatoshi","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"ヤマモト, ハルコ","creatorNameLang":"ja"},{"creatorName":"ヤマモト, ハルコ","creatorNameLang":"ja-Kana"},{"creatorName":"Yamamoto, Haruko","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"イノウエ, マナブ","creatorNameLang":"ja"},{"creatorName":"イノウエ, マナブ","creatorNameLang":"ja-Kana"},{"creatorName":"Inoue, Manabu","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"アサクラ, コウコ","creatorNameLang":"ja"},{"creatorName":"アサクラ, コウコ","creatorNameLang":"ja-Kana"},{"creatorName":"Asakura, Koko","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"アオキ, ジュンヤ","creatorNameLang":"ja"},{"creatorName":"アオキ, ジュンヤ","creatorNameLang":"ja-Kana"},{"creatorName":"Aoki, Junya","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"ハマサキ, トシミツ","creatorNameLang":"ja"},{"creatorName":"ハマサキ, トシミツ","creatorNameLang":"ja-Kana"},{"creatorName":"Hamasaki, Toshimitsu","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"カンザワ, タカオ","creatorNameLang":"ja"},{"creatorName":"カンザワ, タカオ","creatorNameLang":"ja-Kana"},{"creatorName":"Kanzawa, Takao","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"コンドウ, レイ","creatorNameLang":"ja"},{"creatorName":"コンドウ, レイ","creatorNameLang":"ja-Kana"},{"creatorName":"Kondo, Rei","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"オオタキ, マサフミ","creatorNameLang":"ja"},{"creatorName":"オオタキ, マサフミ","creatorNameLang":"ja-Kana"},{"creatorName":"Ohtaki, Masafumi","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"イタバシ, リョウ","creatorNameLang":"ja"},{"creatorName":"イタバシ, リョウ","creatorNameLang":"ja-Kana"},{"creatorName":"Itabashi, Ryo","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"カミヤマ, ケンジ","creatorNameLang":"ja"},{"creatorName":"カミヤマ, ケンジ","creatorNameLang":"ja-Kana"},{"creatorName":"Kamiyama, Kenji","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"イワマ, トオル","creatorNameLang":"ja"},{"creatorName":"イワマ, トオル","creatorNameLang":"ja-Kana"},{"creatorName":"Iwama, Toru","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"ナカセ, タイゼン","creatorNameLang":"ja"},{"creatorName":"ナカセ, タイゼン","creatorNameLang":"ja-Kana"},{"creatorName":"Nakase, Taizen","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"ヤクシジ, ユウスケ","creatorNameLang":"ja"},{"creatorName":"ヤクシジ, ユウスケ","creatorNameLang":"ja-Kana"},{"creatorName":"Yakushiji, Yusuke","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"イガラシ, シュウイチ","creatorNameLang":"ja"},{"creatorName":"イガラシ, シュウイチ","creatorNameLang":"ja-Kana"},{"creatorName":"Igarashi, Shuichi","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"ナガカネ, ヨシナリ","creatorNameLang":"ja"},{"creatorName":"ナガカネ, ヨシナリ","creatorNameLang":"ja-Kana"},{"creatorName":"Nagakane, Yoshinari","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"タキザワ, シュンヤ","creatorNameLang":"ja"},{"creatorName":"タキザワ, シュンヤ","creatorNameLang":"ja-Kana"},{"creatorName":"Takizawa, Shunya","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"オカダ, ヤスシ","creatorNameLang":"ja"},{"creatorName":"オカダ, ヤスシ","creatorNameLang":"ja-Kana"},{"creatorName":"Okada, Yasushi","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"ドイジリ, リョウスケ","creatorNameLang":"ja"},{"creatorName":"ドイジリ, リョウスケ","creatorNameLang":"ja-Kana"},{"creatorName":"Doijiri, Ryosuke","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"ツジノ, アキラ","creatorNameLang":"ja"},{"creatorName":"ツジノ, アキラ","creatorNameLang":"ja-Kana"},{"creatorName":"Tsujino, Akira","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"イトウ, ヤスヒロ","creatorNameLang":"ja"},{"creatorName":"イトウ, ヤスヒロ","creatorNameLang":"ja-Kana"},{"creatorName":"Ito, Yasuhiro","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"オオニシ, ヒデユキ","creatorNameLang":"ja"},{"creatorName":"オオニシ, ヒデユキ","creatorNameLang":"ja-Kana"},{"creatorName":"Ohnishi, Hideyuki","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"イノウエ, タケシ","creatorNameLang":"ja"},{"creatorName":"イノウエ, タケシ","creatorNameLang":"ja-Kana"},{"creatorName":"Inoue, Takeshi","creatorNameLang":"en"}]},{"creatorAffiliations":[{"affiliationNameIdentifiers":[{"affiliationNameIdentifier":"","affiliationNameIdentifierScheme":"ISNI","affiliationNameIdentifierURI":"http://www.isni.org/isni/"}],"affiliationNames":[{"affiliationName":"","affiliationNameLang":"ja"}]}],"creatorNames":[{"creatorName":"高木, 康志","creatorNameLang":"ja"},{"creatorName":"タカギ, ヤスシ","creatorNameLang":"ja-Kana"},{"creatorName":"Takagi, Yasushi","creatorNameLang":"en"}],"familyNames":[{"familyName":"高木","familyNameLang":"ja"},{"familyName":"タカギ","familyNameLang":"ja-Kana"},{"familyName":"Takagi","familyNameLang":"en"}],"givenNames":[{"givenName":"康志","givenNameLang":"ja"},{"givenName":"ヤスシ","givenNameLang":"ja-Kana"},{"givenName":"Yasushi","givenNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"897","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"334002/profile-ja.html","nameIdentifierScheme":"徳島大学 教育研究者総覧","nameIdentifierURI":"http://pub2.db.tokushima-u.ac.jp/ERD/person/334002/profile-ja.html"}]},{"creatorNames":[{"creatorName":"ハセガワ, ヤスヒロ","creatorNameLang":"ja"},{"creatorName":"ハセガワ, ヤスヒロ","creatorNameLang":"ja-Kana"},{"creatorName":"Hasegawa, Yasuhiro","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"シオカワ, ヨシアキ","creatorNameLang":"ja"},{"creatorName":"シオカワ, ヨシアキ","creatorNameLang":"ja-Kana"},{"creatorName":"Shiokawa, Yoshiaki","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"サカイ, ノブユキ","creatorNameLang":"ja"},{"creatorName":"サカイ, ノブユキ","creatorNameLang":"ja-Kana"},{"creatorName":"Sakai, Nobuyuki","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"オオサキ, マサト","creatorNameLang":"ja"},{"creatorName":"オオサキ, マサト","creatorNameLang":"ja-Kana"},{"creatorName":"Osaki, Masato","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"ウエサカ, ヨシカズ","creatorNameLang":"ja"},{"creatorName":"ウエサカ, ヨシカズ","creatorNameLang":"ja-Kana"},{"creatorName":"Uesaka, Yoshikazu","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"ヨシムラ, シンイチ","creatorNameLang":"ja"},{"creatorName":"ヨシムラ, シンイチ","creatorNameLang":"ja-Kana"},{"creatorName":"Yoshimura, Shinichi","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"ウラベ, タカオ","creatorNameLang":"ja"},{"creatorName":"ウラベ, タカオ","creatorNameLang":"ja-Kana"},{"creatorName":"Urabe, Takao","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"ウエダ, トシヒロ","creatorNameLang":"ja"},{"creatorName":"ウエダ, トシヒロ","creatorNameLang":"ja-Kana"},{"creatorName":"Ueda, Toshihiro","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"イハラ, マサフミ","creatorNameLang":"ja"},{"creatorName":"イハラ, マサフミ","creatorNameLang":"ja-Kana"},{"creatorName":"Ihara, Masafumi","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"キタゾノ, タカナリ","creatorNameLang":"ja"},{"creatorName":"キタゾノ, タカナリ","creatorNameLang":"ja-Kana"},{"creatorName":"Kitazono, Takanari","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"ササキ, マコト","creatorNameLang":"ja"},{"creatorName":"ササキ, マコト","creatorNameLang":"ja-Kana"},{"creatorName":"Sasaki, Makoto","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"オイタ, アキラ","creatorNameLang":"ja"},{"creatorName":"オイタ, アキラ","creatorNameLang":"ja-Kana"},{"creatorName":"Oita, Akira","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"ヨシムラ, ソウヘイ","creatorNameLang":"ja"},{"creatorName":"ヨシムラ, ソウヘイ","creatorNameLang":"ja-Kana"},{"creatorName":"Yoshimura, Sohei","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"フクダ ドイ, マユミ","creatorNameLang":"ja"},{"creatorName":"フクダ ドイ, マユミ","creatorNameLang":"ja-Kana"},{"creatorName":"Fukuda-Doi, Mayumi","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"ミワ, カオリ","creatorNameLang":"ja"},{"creatorName":"ミワ, カオリ","creatorNameLang":"ja-Kana"},{"creatorName":"Miwa, Kaori","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"キムラ, カズミ","creatorNameLang":"ja"},{"creatorName":"キムラ, カズミ","creatorNameLang":"ja-Kana"},{"creatorName":"Kimura, Kazumi","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"ミネマツ, カズオ","creatorNameLang":"ja"},{"creatorName":"ミネマツ, カズオ","creatorNameLang":"ja-Kana"},{"creatorName":"Minematsu, Kazuo","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"トヨダ, カズノリ","creatorNameLang":"ja"},{"creatorName":"トヨダ, カズノリ","creatorNameLang":"ja-Kana"},{"creatorName":"Toyoda, Kazunori","creatorNameLang":"en"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_access","date":[{"dateType":"Available","dateValue":"2021-05-19"}],"displaytype":"detail","filename":"stroke_51_5_1530.pdf","filesize":[{"value":"923 KB"}],"format":"application/pdf","licensetype":"license_5","mimetype":"application/pdf","url":{"objectType":"fulltext","url":"https://tokushima-u.repo.nii.ac.jp/record/2008730/files/stroke_51_5_1530.pdf"},"version_id":"ed8687c1-2f8a-4ebb-9c86-c99000eec71c"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"control groups","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"informed consent","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"intracranial hemorrhages","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"magnetic resonance imaging","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"stroke, acute","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"tissue-type plasminogen activator","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Thrombolysis With Alteplase at 0.6 mg/kg for Stroke With Unknown Time of Onset : A Randomized Controlled Trial","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Thrombolysis With Alteplase at 0.6 mg/kg for Stroke With Unknown Time of Onset : A Randomized Controlled Trial","subitem_title_language":"en"}]},"item_type_id":"40001","owner":"7","path":["1713853295607"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2021-05-19"},"publish_date":"2021-05-19","publish_status":"0","recid":"2008730","relation_version_is_last":true,"title":["Thrombolysis With Alteplase at 0.6 mg/kg for Stroke With Unknown Time of Onset : A Randomized Controlled Trial"],"weko_creator_id":"7","weko_shared_id":-1},"updated":"2025-02-13T04:50:29.435491+00:00"}