{"created":"2024-11-22T07:43:29.785983+00:00","id":2008782,"links":{},"metadata":{"_buckets":{"deposit":"3586c68c-31a9-4cf1-947e-3c52cd6c8f38"},"_deposit":{"created_by":7,"id":"2008782","owners":[7],"pid":{"revision_id":0,"type":"depid","value":"2008782"},"status":"published"},"_oai":{"id":"oai:tokushima-u.repo.nii.ac.jp:02008782","sets":["1713853213384:1713853295607"]},"author_link":["666"],"item_10001_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2021-04-01","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"4","bibliographicPageEnd":"313","bibliographicPageStart":"303","bibliographicVolumeNumber":"69","bibliographic_titles":[{"bibliographic_title":"Chemical and Pharmaceutical Bulletin","bibliographic_titleLang":"en"}]}]},"item_10001_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Non-canonical amino acid derivatives are an attractive scaffold for novel drug candidates. Among the methods used to prepare this motif, the asymmetric Mannich-type reaction of α-imino carboxylic acid derivatives is a preeminent strategy because a wide variety of non-canonical amino acids can be accessed by changing only the nucleophile. Preparing the common substrate is difficult, however, which makes this method problematic. We developed a convenient method for synthesizing common substrates using MnO2-mediated oxidation of stable precursors. Peptides bearing non-canonical amino acids are another attractive synthetic target. We propose a new approach for synthesizing non-canonical amino acid-containing peptides by directly applying various organic reactions to peptidic substrates. Using hydrophobic anchor-supported peptides, we directly applied ring-closing metathesis and asymmetric Friedel–Crafts reactions to peptidic substrates. We also developed a novel recyclable organocatalyst according to the nature of the hydrophobic anchor tagged compound.","subitem_description_language":"en","subitem_description_type":"Abstract"}]},"item_10001_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"The Pharmaceutical Society of Japan","subitem_publisher_language":"en"}]},"item_10001_source_id_9":{"attribute_name":"収録物ID","attribute_value_mlt":[{"subitem_source_identifier":"00092363","subitem_source_identifier_type":"ISSN"},{"subitem_source_identifier":"13475223","subitem_source_identifier_type":"ISSN"},{"subitem_source_identifier":"AA00602100","subitem_source_identifier_type":"NCID"}]},"item_10001_version_type_20":{"attribute_name":"出版タイプ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_1715043197608":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"open access"}]},"item_1722929371688":{"attribute_name":"出版社版DOI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_language":"ja","subitem_relation_name_text":"10.1248/cpb.c21-00031"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://doi.org/10.1248/cpb.c21-00031","subitem_relation_type_select":"DOI"}}]},"item_1723180141928":{"attribute_name":"EID","attribute_value_mlt":[{"subitem_identifier_type":"URI","subitem_identifier_uri":"374683"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorAffiliations":[{"affiliationNameIdentifiers":[{"affiliationNameIdentifier":"","affiliationNameIdentifierScheme":"ISNI","affiliationNameIdentifierURI":"http://www.isni.org/isni/"}],"affiliationNames":[{"affiliationName":"","affiliationNameLang":"ja"}]}],"creatorNames":[{"creatorName":"猪熊, 翼","creatorNameLang":"ja"},{"creatorName":"イノクマ, ツバサ","creatorNameLang":"ja-Kana"},{"creatorName":"Inokuma, Tsubasa","creatorNameLang":"en"}],"familyNames":[{"familyName":"猪熊","familyNameLang":"ja"},{"familyName":"イノクマ","familyNameLang":"ja-Kana"},{"familyName":"Inokuma","familyNameLang":"en"}],"givenNames":[{"givenName":"翼","givenNameLang":"ja"},{"givenName":"ツバサ","givenNameLang":"ja-Kana"},{"givenName":"Tsubasa","givenNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"666","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"272366/profile-ja.html","nameIdentifierScheme":"徳島大学 教育研究者総覧","nameIdentifierURI":"http://pub2.db.tokushima-u.ac.jp/ERD/person/272366/profile-ja.html"},{"nameIdentifier":"40541272","nameIdentifierScheme":"e-Rad","nameIdentifierURI":"https://nrid.nii.ac.jp/ja/search/?qm=40541272"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_access","date":[{"dateType":"Available","dateValue":"2021-04-05"}],"displaytype":"detail","filename":"cpb_69_4_303.pdf","filesize":[{"value":"3.59 MB"}],"format":"application/pdf","mimetype":"application/pdf","url":{"objectType":"fulltext","url":"https://tokushima-u.repo.nii.ac.jp/record/2008782/files/cpb_69_4_303.pdf"},"version_id":"76552025-1e1a-4b93-8f76-a0910a61eb59"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"non-canonical amino acid derivative","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"peptide","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"α-amino phosphonic acid","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"hydrophobic anchor","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"recyclable organocatalyst","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Synthesis of Non-canonical Amino Acids and Peptide Containing Them for Establishment of the Template for Drug Discovery","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Synthesis of Non-canonical Amino Acids and Peptide Containing Them for Establishment of the Template for Drug Discovery","subitem_title_language":"en"}]},"item_type_id":"40001","owner":"7","path":["1713853295607"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2021-04-05"},"publish_date":"2021-04-05","publish_status":"0","recid":"2008782","relation_version_is_last":true,"title":["Synthesis of Non-canonical Amino Acids and Peptide Containing Them for Establishment of the Template for Drug Discovery"],"weko_creator_id":"7","weko_shared_id":-1},"updated":"2025-01-28T02:56:44.786380+00:00"}