{"created":"2024-11-22T07:46:27.298469+00:00","id":2008821,"links":{},"metadata":{"_buckets":{"deposit":"d1b133f5-781a-4034-b82b-03fec1c470b8"},"_deposit":{"created_by":7,"id":"2008821","owners":[7],"pid":{"revision_id":0,"type":"depid","value":"2008821"},"status":"published"},"_oai":{"id":"oai:tokushima-u.repo.nii.ac.jp:02008821","sets":["1713853213384:1713853295607"]},"author_link":["301"],"control_number":"2008821","item_10001_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2020-08-24","bibliographicIssueDateType":"Issued"},"bibliographicPageStart":"e55896","bibliographicVolumeNumber":"9","bibliographic_titles":[{"bibliographic_title":"eLife","bibliographic_titleLang":"en"}]}]},"item_10001_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Most of peroxisomal matrix proteins including a hydrogen peroxide (H2O2)-decomposing enzyme, catalase, are imported in a peroxisome-targeting signal type-1 (PTS1)-dependent manner. However, little is known about regulation of the membrane-bound protein import machinery. Here, we report that Pex14, a central component of the protein translocation complex in peroxisomal membrane, is phosphorylated in response to oxidative stresses such as H2O2 in mammalian cells. The H2O2-induced phosphorylation of Pex14 at Ser232 suppresses peroxisomal import of catalase in vivo and selectively impairs in vitro the interaction of catalase with the Pex14-Pex5 complex. A phosphomimetic mutant Pex14-S232D elevates the level of cytosolic catalase, but not canonical PTS1-proteins, conferring higher cell resistance to H2O2. We thus suggest that the H2O2-induced phosphorylation of Pex14 spatiotemporally regulates peroxisomal import of catalase, functioning in counteracting action against oxidative stress by the increase of cytosolic catalase.","subitem_description_language":"en","subitem_description_type":"Abstract"}]},"item_10001_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"eLife Sciences Publications","subitem_publisher_language":"en"}]},"item_10001_rights_15":{"attribute_name":"権利情報","attribute_value_mlt":[{"subitem_rights":"This article is distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use and redistribution provided that the original author and source are credited.","subitem_rights_language":"en"}]},"item_10001_source_id_9":{"attribute_name":"収録物ID","attribute_value_mlt":[{"subitem_source_identifier":"2050084X","subitem_source_identifier_type":"ISSN"}]},"item_10001_version_type_20":{"attribute_name":"出版タイプ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_1715043197608":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"open 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Masanao","creatorNameLang":"en"}]},{"creatorAffiliations":[{"affiliationNameIdentifiers":[{"affiliationNameIdentifier":"","affiliationNameIdentifierScheme":"ISNI","affiliationNameIdentifierURI":"http://www.isni.org/isni/"}],"affiliationNames":[{"affiliationName":"","affiliationNameLang":"ja"}]}],"creatorNames":[{"creatorName":"小迫, 英尊","creatorNameLang":"ja"},{"creatorName":"コサコ, ヒデタカ","creatorNameLang":"ja-Kana"},{"creatorName":"Kosako, Hidetaka","creatorNameLang":"en"}],"familyNames":[{"familyName":"小迫","familyNameLang":"ja"},{"familyName":"コサコ","familyNameLang":"ja-Kana"},{"familyName":"Kosako","familyNameLang":"en"}],"givenNames":[{"givenName":"英尊","givenNameLang":"ja"},{"givenName":"ヒデタカ","givenNameLang":"ja-Kana"},{"givenName":"Hidetaka","givenNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"301","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"172252/profile-ja.html","nameIdentifierScheme":"徳島大学 教育研究者総覧","nameIdentifierURI":"http://pub2.db.tokushima-u.ac.jp/ERD/person/172252/profile-ja.html"},{"nameIdentifier":"10291171","nameIdentifierScheme":"e-Rad","nameIdentifierURI":"https://nrid.nii.ac.jp/ja/search/?qm=10291171"}]},{"creatorNames":[{"creatorName":"ナツヤマ, リュウイチ","creatorNameLang":"ja"},{"creatorName":"ナツヤマ, リュウイチ","creatorNameLang":"ja-Kana"},{"creatorName":"Natsuyama, Ryuichi","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"マルタニ, トシヒロ","creatorNameLang":"ja"},{"creatorName":"マルタニ, トシヒロ","creatorNameLang":"ja-Kana"},{"creatorName":"Marutani, Toshihiro","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"フジキ, ユキオ","creatorNameLang":"ja"},{"creatorName":"フジキ, ユキオ","creatorNameLang":"ja-Kana"},{"creatorName":"Fujiki, Yukio","creatorNameLang":"en"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_access","date":[{"dateType":"Available","dateValue":"2021-07-26"}],"displaytype":"detail","filename":"elife_9_e55896.pdf","filesize":[{"value":"2.11 MB"}],"format":"application/pdf","licensetype":"license_0","mimetype":"application/pdf","url":{"objectType":"fulltext","url":"https://tokushima-u.repo.nii.ac.jp/record/2008821/files/elife_9_e55896.pdf"},"version_id":"215fb50d-aa84-4891-8b6a-5d3ea1e56fb9"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"The peroxisome counteracts oxidative stresses by suppressing catalase import via Pex14 phosphorylation","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"The peroxisome counteracts oxidative stresses by suppressing catalase import via Pex14 phosphorylation","subitem_title_language":"en"}]},"item_type_id":"40001","owner":"7","path":["1713853295607"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2021-07-26"},"publish_date":"2021-07-26","publish_status":"0","recid":"2008821","relation_version_is_last":true,"title":["The peroxisome counteracts oxidative stresses by suppressing catalase import via Pex14 phosphorylation"],"weko_creator_id":"7","weko_shared_id":-1},"updated":"2025-01-29T06:55:12.205852+00:00"}