{"created":"2024-12-12T01:05:14.713896+00:00","id":2008962,"links":{},"metadata":{"_buckets":{"deposit":"f90fbb6e-f05e-4b1f-b50d-05080e56a63a"},"_deposit":{"created_by":7,"id":"2008962","owners":[7],"pid":{"revision_id":0,"type":"depid","value":"2008962"},"status":"published"},"_oai":{"id":"oai:tokushima-u.repo.nii.ac.jp:02008962","sets":["1713853213384:1713853295607"]},"author_link":["385","772"],"item_10001_alternative_title_1":{"attribute_name":"タイトル別表記","attribute_value_mlt":[{"subitem_alternative_title":"Fate of an Infectious ERV in Wild and Domestic Cats","subitem_alternative_title_language":"en"}]},"item_10001_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2019-11-26","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"24","bibliographicPageStart":"e01324-19","bibliographicVolumeNumber":"93","bibliographic_titles":[{"bibliographic_title":"Journal of Virology","bibliographic_titleLang":"en"}]}]},"item_10001_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Endogenous retroviruses (ERVs) of domestic cats (ERV-DCs) are one of the youngest feline ERV groups in domestic cats (Felis silvestris catus); some members are replication competent (ERV-DC10, ERV-DC18, and ERV-DC14), produce the antiretroviral soluble factor Refrex-1 (ERV-DC7 and ERV-DC16), or can generate recombinant feline leukemia virus (FeLV). Here, we investigated ERV-DC in European wildcats (Felis silvestris silvestris) and detected four loci: ERV-DC6, ERV-DC7, ERV-DC14, and ERV-DC16. ERV-DC14 was detected at a high frequency in European wildcats; however, it was replication defective due to a single G → A nucleotide substitution, resulting in an E148K substitution in the ERV-DC14 envelope (Env). This mutation results in a cleavage-defective Env that is not incorporated into viral particles. Introduction of the same mutation into feline and murine infectious gammaretroviruses resulted in a similar Env dysfunction. Interestingly, the same mutation was found in an FeLV isolate from naturally occurring thymic lymphoma and a mouse ERV, suggesting a common mechanism of virus inactivation. Refrex-1 was present in European wildcats; however, ERV-DC16, but not ERV-DC7, was unfixed in European wildcats. Thus, Refrex-1 has had an antiviral role throughout the evolution of the genus Felis, predating cat exposure to feline retroviruses. ERV-DC sequence diversity was present across wild and domestic cats but was locus dependent. In conclusion, ERVs have evolved species-specific phenotypes through the interplay between ERVs and their hosts. The mechanism of viral inactivation may be similar irrespective of the evolutionary history of retroviruses. The tracking of ancestral retroviruses can shed light on their roles in pathogenesis and host-virus evolution.","subitem_description_language":"en","subitem_description_type":"Abstract"}]},"item_10001_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"American Society for Microbiology","subitem_publisher_language":"en"}]},"item_10001_source_id_9":{"attribute_name":"収録物ID","attribute_value_mlt":[{"subitem_source_identifier":"10985514","subitem_source_identifier_type":"ISSN"}]},"item_10001_version_type_20":{"attribute_name":"出版タイプ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_1715043197608":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"open access"}]},"item_1722929371688":{"attribute_name":"出版社版DOI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_language":"ja","subitem_relation_name_text":"10.1128/JVI.01324-19"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://doi.org/10.1128/JVI.01324-19","subitem_relation_type_select":"DOI"}}]},"item_1723180141928":{"attribute_name":"EID","attribute_value_mlt":[{"subitem_identifier_type":"URI","subitem_identifier_uri":"370230"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Ngo, Minh Ha","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Arnal, MaríaCruz","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"スミ, リョウスケ","creatorNameLang":"ja"},{"creatorName":"スミ, リョウスケ","creatorNameLang":"ja-Kana"},{"creatorName":"Sumi, Ryosuke","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"カワサキ, ジュンナ","creatorNameLang":"ja"},{"creatorName":"カワサキ, ジュンナ","creatorNameLang":"ja-Kana"},{"creatorName":"Kawasaki, Junna","creatorNameLang":"en"}]},{"creatorAffiliations":[{"affiliationNameIdentifiers":[{"affiliationNameIdentifier":"","affiliationNameIdentifierScheme":"ISNI","affiliationNameIdentifierURI":"http://www.isni.org/isni/"}],"affiliationNames":[{"affiliationName":"","affiliationNameLang":"ja"}]}],"creatorNames":[{"creatorName":"三宅, 在子","creatorNameLang":"ja"},{"creatorName":"ミヤケ, アリコ","creatorNameLang":"ja-Kana"},{"creatorName":"Miyake, Ariko","creatorNameLang":"en"}],"familyNames":[{"familyName":"三宅","familyNameLang":"ja"},{"familyName":"ミヤケ","familyNameLang":"ja-Kana"},{"familyName":"Miyake","familyNameLang":"en"}],"givenNames":[{"givenName":"在子","givenNameLang":"ja"},{"givenName":"アリコ","givenNameLang":"ja-Kana"},{"givenName":"Ariko","givenNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"385","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"20548622","nameIdentifierScheme":"e-Rad","nameIdentifierURI":"https://nrid.nii.ac.jp/ja/search/?qm=20548622"}]},{"creatorNames":[{"creatorName":"Grant, Chris K.","creatorNameLang":"en"}]},{"creatorAffiliations":[{"affiliationNameIdentifiers":[{"affiliationNameIdentifier":"","affiliationNameIdentifierScheme":"ISNI","affiliationNameIdentifierURI":"http://www.isni.org/isni/"}],"affiliationNames":[{"affiliationName":"","affiliationNameLang":"ja"}]}],"creatorNames":[{"creatorName":"音井, 威重","creatorNameLang":"ja"},{"creatorName":"オトイ, タケシゲ","creatorNameLang":"ja-Kana"},{"creatorName":"Otoi, Takeshige","creatorNameLang":"en"}],"familyNames":[{"familyName":"音井","familyNameLang":"ja"},{"familyName":"オトイ","familyNameLang":"ja-Kana"},{"familyName":"Otoi","familyNameLang":"en"}],"givenNames":[{"givenName":"威重","givenNameLang":"ja"},{"givenName":"タケシゲ","givenNameLang":"ja-Kana"},{"givenName":"Takeshige","givenNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"772","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"292974/profile-ja.html","nameIdentifierScheme":"徳島大学 教育研究者総覧","nameIdentifierURI":"http://pub2.db.tokushima-u.ac.jp/ERD/person/292974/profile-ja.html"},{"nameIdentifier":"30311814","nameIdentifierScheme":"e-Rad","nameIdentifierURI":"https://nrid.nii.ac.jp/ja/search/?qm=30311814"}]},{"creatorNames":[{"creatorName":"de Luco, Daniel Fernández","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"ニシガキ, カズオ","creatorNameLang":"ja"},{"creatorName":"ニシガキ, カズオ","creatorNameLang":"ja-Kana"},{"creatorName":"Nishigaki, Kazuo","creatorNameLang":"en"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_access","date":[{"dateType":"Available","dateValue":"2021-06-01"}],"displaytype":"detail","filename":"JVI_93_24_e01324-19.pdf","filesize":[{"value":"5.31 MB"}],"format":"application/pdf","mimetype":"application/pdf","url":{"objectType":"fulltext","url":"https://tokushima-u.repo.nii.ac.jp/record/2008962/files/JVI_93_24_e01324-19.pdf"},"version_id":"28c176d0-35d5-45f4-9e67-283b3735cf92"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"ERV-DC","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"endogenous retrovirus","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Fv-4","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"FeLV","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Felis","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"MuLV","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"domestic cat","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"domestication","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"evolution","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"wildcat","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Tracking the Fate of Endogenous Retrovirus Segregation in Wild and Domestic Cats","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Tracking the Fate of Endogenous Retrovirus Segregation in Wild and Domestic Cats","subitem_title_language":"en"}]},"item_type_id":"40001","owner":"7","path":["1713853295607"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2021-06-01"},"publish_date":"2021-06-01","publish_status":"0","recid":"2008962","relation_version_is_last":true,"title":["Tracking the Fate of Endogenous Retrovirus Segregation in Wild and Domestic Cats"],"weko_creator_id":"7","weko_shared_id":-1},"updated":"2025-01-29T10:53:38.650410+00:00"}