{"created":"2024-12-12T01:06:01.208585+00:00","id":2008973,"links":{},"metadata":{"_buckets":{"deposit":"b5198027-30f1-4c92-bf32-dc6117fd1044"},"_deposit":{"created_by":7,"id":"2008973","owners":[7],"pid":{"revision_id":0,"type":"depid","value":"2008973"},"status":"published"},"_oai":{"id":"oai:tokushima-u.repo.nii.ac.jp:02008973","sets":["1713829974766:1713854682253:1716422246820:1716422691716","1713853213384:1713853295607"]},"author_link":["521","1418","818","943","1005","168","482","228","1415"],"item_10001_alternative_title_1":{"attribute_name":"タイトル別表記","attribute_value_mlt":[{"subitem_alternative_title":"Drug evaluation using pharmacologically induced aortic dissection prone model mice","subitem_alternative_title_language":"en"}]},"item_10001_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2021-04-25","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"1-2","bibliographicPageEnd":"62","bibliographicPageStart":"57","bibliographicVolumeNumber":"77","bibliographic_titles":[{"bibliographic_title":"四国医学雑誌","bibliographic_titleLang":"ja"},{"bibliographic_title":"Shikoku Acta Medica","bibliographic_titleLang":"en"}]}]},"item_10001_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Aortic dissection (or dissecting aortic aneurysm) is a condition in which the aortic wall is separated into two layers at the medial level to form a pseudocavity. The intima crack, called the “entry”, allows blood to tear through the medial layer and flow in. The location of the “entry” and the extent of the dissection can cause a variety of serious complications, including rupture, cardiac tamponade, and obstruction of branched vessels. According to the Guideline on Diagnosis and Treatment of Aortic Aneurysm and Aortic Dissection 2020, it is estimated that 61.4% of the onset of dissection die before arrival at the hospital, and 93% will die within 24 hours after the onset. It has been suggested that the morbidity rate has been increasing in recent years. Since many of them have a fatal prognosis, it is an important issue to prevent the onset itself. However, no effective therapeutic agent or preventive strategy has been established so far. The first reason is that it is extremely difficult to design clinical studies because aortic dissection traced the rapid onset and progression. The second is that the pathophysiology and preventive drug search are not sufficiently conducted even at the basic research level. Epidemiologically, the results of the International Registry of Aortic Dissection (IRAD) revealed that aging, hypertension, atherosclerosis, and hereditary connective tissue diseases are risk factors. The aortic aneurysm also shows similar pathological conditions caused by these risk factors. However, one of the major differences between aneurysm and dissection is the presence of aortic intima rupture. Therefore, we attempted to establish a mouse model developing dissection at a high rate by adding the endothelial dysfunction to a pharmacologically induced aortic aneurysm model mouse. Furthermore, we evaluated the efficacy of pitavastatin and several nutrients using our novel model mice and verified its usefulness as a model animal.","subitem_description_language":"en","subitem_description_type":"Abstract"}]},"item_10001_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"徳島医学会","subitem_publisher_language":"ja"}]},"item_10001_source_id_9":{"attribute_name":"収録物ID","attribute_value_mlt":[{"subitem_source_identifier":"00373699","subitem_source_identifier_type":"ISSN"},{"subitem_source_identifier":"AN00102041","subitem_source_identifier_type":"NCID"}]},"item_10001_version_type_20":{"attribute_name":"出版タイプ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_1715043197608":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"open access"}]},"item_1723180141928":{"attribute_name":"EID","attribute_value_mlt":[{"subitem_identifier_type":"URI","subitem_identifier_uri":"390121"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorAffiliations":[{"affiliationNameIdentifiers":[{"affiliationNameIdentifier":"","affiliationNameIdentifierScheme":"ISNI","affiliationNameIdentifierURI":"http://www.isni.org/isni/"}],"affiliationNames":[{"affiliationName":"","affiliationNameLang":"ja"}]}],"creatorNames":[{"creatorName":"(井澤)石澤, 有紀","creatorNameLang":"ja"},{"creatorName":"(イザワ)イシザワ, ユキ","creatorNameLang":"ja-Kana"},{"creatorName":"Izawa-Ishizawa, Yuki","creatorNameLang":"en"}],"familyNames":[{"familyName":"(井澤)石澤","familyNameLang":"ja"},{"familyName":"(イザワ)イシザワ","familyNameLang":"ja-Kana"},{"familyName":"Izawa-Ishizawa","familyNameLang":"en"}],"givenNames":[{"givenName":"有紀","givenNameLang":"ja"},{"givenName":"ユキ","givenNameLang":"ja-Kana"},{"givenName":"Yuki","givenNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"521","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"229223/profile-ja.html","nameIdentifierScheme":"徳島大学 教育研究者総覧","nameIdentifierURI":"http://pub2.db.tokushima-u.ac.jp/ERD/person/229223/profile-ja.html"},{"nameIdentifier":"40610192","nameIdentifierScheme":"e-Rad","nameIdentifierURI":"https://nrid.nii.ac.jp/ja/search/?qm=40610192"}]},{"creatorAffiliations":[{"affiliationNameIdentifiers":[{"affiliationNameIdentifier":"","affiliationNameIdentifierScheme":"ISNI","affiliationNameIdentifierURI":"http://www.isni.org/isni/"}],"affiliationNames":[{"affiliationName":"","affiliationNameLang":"ja"}]}],"creatorNames":[{"creatorName":"合田, 光寛","creatorNameLang":"ja"},{"creatorName":"ゴウダ, ミツヒロ","creatorNameLang":"ja-Kana"},{"creatorName":"Goda, Mitsuhiro","creatorNameLang":"en"}],"familyNames":[{"familyName":"合田","familyNameLang":"ja"},{"familyName":"ゴウダ","familyNameLang":"ja-Kana"},{"familyName":"Goda","familyNameLang":"en"}],"givenNames":[{"givenName":"光寛","givenNameLang":"ja"},{"givenName":"ミツヒロ","givenNameLang":"ja-Kana"},{"givenName":"Mitsuhiro","givenNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"943","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"348309/profile-ja.html","nameIdentifierScheme":"徳島大学 教育研究者総覧","nameIdentifierURI":"http://pub2.db.tokushima-u.ac.jp/ERD/person/348309/profile-ja.html"},{"nameIdentifier":"40585965","nameIdentifierScheme":"e-Rad","nameIdentifierURI":"https://nrid.nii.ac.jp/ja/search/?qm=40585965"}]},{"creatorAffiliations":[{"affiliationNameIdentifiers":[{"affiliationNameIdentifier":"","affiliationNameIdentifierScheme":"ISNI","affiliationNameIdentifierURI":"http://www.isni.org/isni/"}],"affiliationNames":[{"affiliationName":"","affiliationNameLang":"ja"}]}],"creatorNames":[{"creatorName":"相澤, 風花","creatorNameLang":"ja"},{"creatorName":"アイザワ, フウカ","creatorNameLang":"ja-Kana"},{"creatorName":"Aizawa, Fuka","creatorNameLang":"en"}],"familyNames":[{"familyName":"相澤","familyNameLang":"ja"},{"familyName":"アイザワ","familyNameLang":"ja-Kana"},{"familyName":"Aizawa","familyNameLang":"en"}],"givenNames":[{"givenName":"風花","givenNameLang":"ja"},{"givenName":"フウカ","givenNameLang":"ja-Kana"},{"givenName":"Fuka","givenNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"1415","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"372292/profile-ja.html","nameIdentifierScheme":"徳島大学 教育研究者総覧","nameIdentifierURI":"http://pub2.db.tokushima-u.ac.jp/ERD/person/372292/profile-ja.html"},{"nameIdentifier":"80848367","nameIdentifierScheme":"e-Rad","nameIdentifierURI":"https://nrid.nii.ac.jp/ja/search/?qm=80848367"}]},{"creatorAffiliations":[{"affiliationNameIdentifiers":[{"affiliationNameIdentifier":"","affiliationNameIdentifierScheme":"ISNI","affiliationNameIdentifierURI":"http://www.isni.org/isni/"}],"affiliationNames":[{"affiliationName":"","affiliationNameLang":"ja"}]}],"creatorNames":[{"creatorName":"座間味, 義人","creatorNameLang":"ja"},{"creatorName":"ザマミ, ヨシト","creatorNameLang":"ja-Kana"},{"creatorName":"Zamami, Yoshito","creatorNameLang":"en"}],"familyNames":[{"familyName":"座間味","familyNameLang":"ja"},{"familyName":"ザマミ","familyNameLang":"ja-Kana"},{"familyName":"Zamami","familyNameLang":"en"}],"givenNames":[{"givenName":"義人","givenNameLang":"ja"},{"givenName":"ヨシト","givenNameLang":"ja-Kana"},{"givenName":"Yoshito","givenNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"818","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"70550250","nameIdentifierScheme":"e-Rad","nameIdentifierURI":"https://nrid.nii.ac.jp/ja/search/?qm=70550250"}]},{"creatorAffiliations":[{"affiliationNameIdentifiers":[{"affiliationNameIdentifier":"","affiliationNameIdentifierScheme":"ISNI","affiliationNameIdentifierURI":"http://www.isni.org/isni/"}],"affiliationNames":[{"affiliationName":"","affiliationNameLang":"ja"}]}],"creatorNames":[{"creatorName":"濱野, 裕章","creatorNameLang":"ja"},{"creatorName":"ハマノ, ヒロフミ","creatorNameLang":"ja-Kana"},{"creatorName":"Hamano, Hirofumi","creatorNameLang":"en"}],"familyNames":[{"familyName":"濱野","familyNameLang":"ja"},{"familyName":"ハマノ","familyNameLang":"ja-Kana"},{"familyName":"Hamano","familyNameLang":"en"}],"givenNames":[{"givenName":"裕章","givenNameLang":"ja"},{"givenName":"ヒロフミ","givenNameLang":"ja-Kana"},{"givenName":"Hirofumi","givenNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"1418","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"373198/profile-ja.html","nameIdentifierScheme":"徳島大学 教育研究者総覧","nameIdentifierURI":"http://pub2.db.tokushima-u.ac.jp/ERD/person/373198/profile-ja.html"},{"nameIdentifier":"10847289","nameIdentifierScheme":"e-Rad","nameIdentifierURI":"https://nrid.nii.ac.jp/ja/search/?qm=10847289"}]},{"creatorAffiliations":[{"affiliationNameIdentifiers":[{"affiliationNameIdentifier":"","affiliationNameIdentifierScheme":"ISNI","affiliationNameIdentifierURI":"http://www.isni.org/isni/"}],"affiliationNames":[{"affiliationName":"","affiliationNameLang":"ja"}]}],"creatorNames":[{"creatorName":"八木, 健太","creatorNameLang":"ja"},{"creatorName":"ヤギ, ケンタ","creatorNameLang":"ja-Kana"},{"creatorName":"Yagi, Kenta","creatorNameLang":"en"}],"familyNames":[{"familyName":"八木","familyNameLang":"ja"},{"familyName":"ヤギ","familyNameLang":"ja-Kana"},{"familyName":"Yagi","familyNameLang":"en"}],"givenNames":[{"givenName":"健太","givenNameLang":"ja"},{"givenName":"ケンタ","givenNameLang":"ja-Kana"},{"givenName":"Kenta","givenNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"1005","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"364589/profile-ja.html","nameIdentifierScheme":"徳島大学 教育研究者総覧","nameIdentifierURI":"http://pub2.db.tokushima-u.ac.jp/ERD/person/364589/profile-ja.html"}]},{"creatorAffiliations":[{"affiliationNameIdentifiers":[{"affiliationNameIdentifier":"","affiliationNameIdentifierScheme":"ISNI","affiliationNameIdentifierURI":"http://www.isni.org/isni/"}],"affiliationNames":[{"affiliationName":"","affiliationNameLang":"ja"}]}],"creatorNames":[{"creatorName":"池田, 康将","creatorNameLang":"ja"},{"creatorName":"イケダ, ヤスマサ","creatorNameLang":"ja-Kana"},{"creatorName":"Ikeda, Yasumasa","creatorNameLang":"en"}],"familyNames":[{"familyName":"池田","familyNameLang":"ja"},{"familyName":"イケダ","familyNameLang":"ja-Kana"},{"familyName":"Ikeda","familyNameLang":"en"}],"givenNames":[{"givenName":"康将","givenNameLang":"ja"},{"givenName":"ヤスマサ","givenNameLang":"ja-Kana"},{"givenName":"Yasumasa","givenNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"482","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"219499/profile-ja.html","nameIdentifierScheme":"徳島大学 教育研究者総覧","nameIdentifierURI":"http://pub2.db.tokushima-u.ac.jp/ERD/person/219499/profile-ja.html"},{"nameIdentifier":"60432754","nameIdentifierScheme":"e-Rad","nameIdentifierURI":"https://nrid.nii.ac.jp/ja/search/?qm=60432754"}]},{"creatorAffiliations":[{"affiliationNameIdentifiers":[{"affiliationNameIdentifier":"","affiliationNameIdentifierScheme":"ISNI","affiliationNameIdentifierURI":"http://www.isni.org/isni/"}],"affiliationNames":[{"affiliationName":"","affiliationNameLang":"ja"}]}],"creatorNames":[{"creatorName":"石澤, 啓介","creatorNameLang":"ja"},{"creatorName":"イシザワ, ケイスケ","creatorNameLang":"ja-Kana"},{"creatorName":"Ishizawa, Keisuke","creatorNameLang":"en"}],"familyNames":[{"familyName":"石澤","familyNameLang":"ja"},{"familyName":"イシザワ","familyNameLang":"ja-Kana"},{"familyName":"Ishizawa","familyNameLang":"en"}],"givenNames":[{"givenName":"啓介","givenNameLang":"ja"},{"givenName":"ケイスケ","givenNameLang":"ja-Kana"},{"givenName":"Keisuke","givenNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"228","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"141809/profile-ja.html","nameIdentifierScheme":"徳島大学 教育研究者総覧","nameIdentifierURI":"http://pub2.db.tokushima-u.ac.jp/ERD/person/141809/profile-ja.html"},{"nameIdentifier":"60398013","nameIdentifierScheme":"e-Rad","nameIdentifierURI":"https://nrid.nii.ac.jp/ja/search/?qm=60398013"}]},{"creatorAffiliations":[{"affiliationNameIdentifiers":[{"affiliationNameIdentifier":"","affiliationNameIdentifierScheme":"ISNI","affiliationNameIdentifierURI":"http://www.isni.org/isni/"}],"affiliationNames":[{"affiliationName":"","affiliationNameLang":"ja"}]}],"creatorNames":[{"creatorName":"玉置, 俊晃","creatorNameLang":"ja"},{"creatorName":"タマキ, トシアキ","creatorNameLang":"ja-Kana"},{"creatorName":"Tamaki, Toshiaki","creatorNameLang":"en"}],"familyNames":[{"familyName":"玉置","familyNameLang":"ja"},{"familyName":"タマキ","familyNameLang":"ja-Kana"},{"familyName":"Tamaki","familyNameLang":"en"}],"givenNames":[{"givenName":"俊晃","givenNameLang":"ja"},{"givenName":"トシアキ","givenNameLang":"ja-Kana"},{"givenName":"Toshiaki","givenNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"168","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"10948/profile-ja.html","nameIdentifierScheme":"徳島大学 教育研究者総覧","nameIdentifierURI":"http://pub2.db.tokushima-u.ac.jp/ERD/person/10948/profile-ja.html"},{"nameIdentifier":"80179879","nameIdentifierScheme":"e-Rad","nameIdentifierURI":"https://nrid.nii.ac.jp/ja/search/?qm=80179879"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_access","date":[{"dateType":"Available","dateValue":"2021-06-09"}],"displaytype":"detail","filename":"sam_77_1-2_57.pdf","filesize":[{"value":"3.42 MB"}],"format":"application/pdf","mimetype":"application/pdf","url":{"objectType":"fulltext","url":"https://tokushima-u.repo.nii.ac.jp/record/2008973/files/sam_77_1-2_57.pdf"},"version_id":"b9af1e07-1f96-44c1-bd8f-55d8b09e24a0"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"aortic dissection","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"endothelial dysfunction","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"statin","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"polyphenol","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"large medical databases","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"薬剤誘発性大動脈解離易発症モデルマウスを用いた薬効評価","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"薬剤誘発性大動脈解離易発症モデルマウスを用いた薬効評価","subitem_title_language":"ja"}]},"item_type_id":"40001","owner":"7","path":["1713853295607","1716422691716"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2021-06-09"},"publish_date":"2021-06-09","publish_status":"0","recid":"2008973","relation_version_is_last":true,"title":["薬剤誘発性大動脈解離易発症モデルマウスを用いた薬効評価"],"weko_creator_id":"7","weko_shared_id":-1},"updated":"2025-04-28T06:47:30.206669+00:00"}