{"created":"2024-12-12T01:07:47.951743+00:00","id":2008995,"links":{},"metadata":{"_buckets":{"deposit":"2f769d59-57da-4a7d-841f-abb091c3fab0"},"_deposit":{"created_by":7,"id":"2008995","owners":[7],"pid":{"revision_id":0,"type":"depid","value":"2008995"},"status":"published"},"_oai":{"id":"oai:tokushima-u.repo.nii.ac.jp:02008995","sets":["1713853213384:1713853296295:1716267877313:1716268556148"]},"author_link":["1251","599","982","851","323"],"item_10001_alternative_title_1":{"attribute_name":"タイトル別表記","attribute_value_mlt":[{"subitem_alternative_title":"変形性顎関節症の進展におけるp21の免疫調節作用","subitem_alternative_title_language":"ja"}]},"item_10001_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2021-02-10","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"3","bibliographicPageEnd":"322","bibliographicPageStart":"313","bibliographicVolumeNumber":"7","bibliographic_titles":[{"bibliographic_title":"Clinical and Experimental Dental Research","bibliographic_titleLang":"en"}]}]},"item_10001_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Objective: We aimed to identify the immunoregulatory role of the cyclin-dependent kinase inhibitor p21 in the homeostasis of mandibular condylar cartilage affected by mechanical stress.\nMaterials and Methods: Ten C57BL/6 wild-type (WT) and ten p21–/– mice aged 8 weeks were divided into the untreated and treated groups. In the treated groups, mechanical stress was applied to the temporomandibular joint (TMJ) through forced mouth opening for 3 h/day for 7 days. The dissected TMJs were assessed using micro-CT, histology, and immunohistochemistry.\nResults: Treated p21–/– condyles with mechanical stress revealed more severe subchondral bone destruction, with thinner cartilage layers and smaller proteoglycan area relative to treated WT condyles; untreated WT and p21–/– condyles had smoother surfaces. Immunohistochemistry revealed significant increases in the numbers of Caspase-3, interleukin-1β, matrix metalloprotease (MMP)-9, and MMP-13 positive cells, and few aggrecan positive cells, in treated p21–/– than in treated WT samples. Moreover, the number of TUNEL positive cells markedly increased in p21–/– condyles affected by mechanical stress.\nConclusion: Our findings indicate that p21 in chondrocytes contributes to regulate matrix synthesis via the control of aggrecan and MMP-13 expression under mechanical stress. Thus, p21 might regulate the pathogenesis of osteoarthritis in the TMJ.","subitem_description_language":"en","subitem_description_type":"Abstract"}]},"item_10001_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Wiley","subitem_publisher_language":"en"}]},"item_10001_rights_15":{"attribute_name":"権利情報","attribute_value_mlt":[{"subitem_rights":"This is an open access article under the terms of the Creative Commons Attribution License ( https://creativecommons.org/licenses/by/4.0/ ), which permits use, distribution and reproduction in any medium, provided the original work is properly cited.","subitem_rights_language":"en"}]},"item_10001_source_id_9":{"attribute_name":"収録物ID","attribute_value_mlt":[{"subitem_source_identifier":"20574347","subitem_source_identifier_type":"ISSN"}]},"item_10001_version_type_20":{"attribute_name":"出版タイプ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_be7fb7dd8ff6fe43","subitem_version_type":"NA"}]},"item_1714461018643":{"attribute_name":"報告番号","attribute_value_mlt":[{"subitem_dissertationnumber":"甲第3493号"}]},"item_1714461102074":{"attribute_name":"学位名","attribute_value_mlt":[{"subitem_degreename":"博士（歯学）","subitem_degreename_language":"ja"}]},"item_1714461118377":{"attribute_name":"学位授与年月日","attribute_value_mlt":[{"subitem_dategranted":"2021-03-23"}]},"item_1714461137393":{"attribute_name":"学位授与機関","attribute_value_mlt":[{"subitem_degreegrantor":[{"subitem_degreegrantor_language":"ja","subitem_degreegrantor_name":"徳島大学"}]}]},"item_1715043197608":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"open access"}]},"item_1718868208704":{"attribute_name":"備考","attribute_value_mlt":[{"subitem_textarea_language":"ja","subitem_textarea_value":"内容要旨・審査要旨・論文本文の公開\n本論文は，著者Tsendsuren Khurel-Ochirの学位論文として提出され，学位審査・授与の対象となっている。\n学位授与者所属 : 徳島大学大学院口腔科学教育部（口腔科学専攻）"}]},"item_1718868303842":{"attribute_name":"学位記番号","attribute_value_mlt":[{"subitem_text_language":"ja","subitem_text_value":"甲口第471号"}]},"item_1722929371688":{"attribute_name":"出版社版DOI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_language":"ja","subitem_relation_name_text":"10.1002/cre2.404"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://doi.org/10.1002/cre2.404","subitem_relation_type_select":"DOI"}}]},"item_1723180141928":{"attribute_name":"EID","attribute_value_mlt":[{"subitem_identifier_type":"URI","subitem_identifier_uri":"376413"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"フゥレル オチル, ツェンドスレン","creatorNameLang":"ja"},{"creatorName":"フゥレル オチル, ツェンドスレン","creatorNameLang":"ja-Kana"},{"creatorName":"khurel-Ochir, Tsendsuren","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"井澤, 俊","creatorNameLang":"ja"}],"nameIdentifiers":[{"nameIdentifier":"1251","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"岩浅, 亮彦","creatorNameLang":"ja"}],"nameIdentifiers":[{"nameIdentifier":"599","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"加納, 史也","creatorNameLang":"ja"}],"nameIdentifiers":[{"nameIdentifier":"982","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"山本, 朗仁","creatorNameLang":"ja"}],"nameIdentifiers":[{"nameIdentifier":"851","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"田中, 栄二","creatorNameLang":"ja"}],"nameIdentifiers":[{"nameIdentifier":"323","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_access","date":[{"dateType":"Available","dateValue":"2021-06-22"}],"displaytype":"detail","filename":"k3493_abstract.pdf","filesize":[{"value":"105 KB"}],"format":"application/pdf","mimetype":"application/pdf","url":{"objectType":"abstract","url":"https://tokushima-u.repo.nii.ac.jp/record/2008995/files/k3493_abstract.pdf"},"version_id":"786fc58e-4631-4aee-9923-5b7f22e40752"},{"accessrole":"open_access","date":[{"dateType":"Available","dateValue":"2021-06-22"}],"displaytype":"detail","filename":"k3493_review.pdf","filesize":[{"value":"54.8 KB"}],"format":"application/pdf","mimetype":"application/pdf","url":{"objectType":"other","url":"https://tokushima-u.repo.nii.ac.jp/record/2008995/files/k3493_review.pdf"},"version_id":"772e18e8-2438-442a-80bb-ac90a24dc4e3"},{"accessrole":"open_access","date":[{"dateType":"Available","dateValue":"2021-06-22"}],"displaytype":"detail","filename":"k3493_fulltext.pdf","filesize":[{"value":"20.4 MB"}],"format":"application/pdf","mimetype":"application/pdf","url":{"objectType":"fulltext","url":"https://tokushima-u.repo.nii.ac.jp/record/2008995/files/k3493_fulltext.pdf"},"version_id":"1ff99a2d-e9a9-4e6b-91b4-4dd034467ffd"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"p21","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"chondrocytes","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"temporomandibular joint","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"osteoarthritis","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"metalloprotease","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"chondrocyte","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"doctoral thesis","resourceuri":"http://purl.org/coar/resource_type/c_db06"}]},"item_title":"The immunoregulatory role of p21 in the development of the temporomandibular joint- osteoarthritis","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"The immunoregulatory role of p21 in the development of the temporomandibular joint- osteoarthritis","subitem_title_language":"en"}]},"item_type_id":"40001","owner":"7","path":["1716268556148"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2021-06-22"},"publish_date":"2021-06-22","publish_status":"0","recid":"2008995","relation_version_is_last":true,"title":["The immunoregulatory role of p21 in the development of the temporomandibular joint- osteoarthritis"],"weko_creator_id":"7","weko_shared_id":-1},"updated":"2024-12-12T01:07:56.783324+00:00"}