{"created":"2024-12-12T01:12:20.657264+00:00","id":2009059,"links":{},"metadata":{"_buckets":{"deposit":"c21e1ab1-9c91-4c6c-8349-123805d3ae2b"},"_deposit":{"created_by":7,"id":"2009059","owners":[7],"pid":{"revision_id":0,"type":"depid","value":"2009059"},"status":"published"},"_oai":{"id":"oai:tokushima-u.repo.nii.ac.jp:02009059","sets":["1713853213384:1713853296295:1716267877313:1716268556148"]},"author_link":["248","479","750","706","1689","1549","589"],"item_10001_alternative_title_1":{"attribute_name":"タイトル別表記","attribute_value_mlt":[{"subitem_alternative_title":"軽度な慢性ストレスはマウスの睡眠を障害し疼痛感受性を増大させる","subitem_alternative_title_language":"ja"}]},"item_10001_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2021-07-09","bibliographicIssueDateType":"Issued"},"bibliographicPageStart":"14231","bibliographicVolumeNumber":"11","bibliographic_titles":[{"bibliographic_title":"Scientific Reports","bibliographic_titleLang":"en"}]}]},"item_10001_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Even though it has been well documented that stress can lead to the development of sleep disorders and the intensification of pain, their relationships have not been fully understood. The present study was aimed at investigating the effects of predictable chronic mild stress (PCMS) on sleep–wake states and pain threshold, using the PCMS rearing conditions of mesh wire (MW) and water (W) for 21 days. Exposure to PCMS decreased the amount of non-rapid eye movement (NREM) sleep during the dark phase. Moreover, the chronicity of PCMS decreased slow-wave activity (SWA) during NREM sleep in the MW and W groups in both the light and dark phases. Mechanical and aversively hot thermal hyperalgesia were more intensified in the PCMS groups than the control. Higher plasma corticosterone levels were seen in mice subjected to PCMS, whereas TNF-α expression was found higher in the hypothalamus in the W and the trigeminal ganglion in the MW group. The W group had higher expression levels of IL-6 in the thalamus as well. The PCMS paradigm decreased SWA and may have intensified mechanical and thermal hyperalgesia. The current study also suggests that rearing under PCMS may cause impaired sleep quality and heightened pain sensation to painful mechanical and aversively hot thermal stimuli.","subitem_description_language":"en","subitem_description_type":"Abstract"}]},"item_10001_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Springer Nature","subitem_publisher_language":"en"}]},"item_10001_rights_15":{"attribute_name":"権利情報","attribute_value_mlt":[{"subitem_rights":"This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.","subitem_rights_language":"en"}]},"item_10001_source_id_9":{"attribute_name":"収録物ID","attribute_value_mlt":[{"subitem_source_identifier":"20452322","subitem_source_identifier_type":"ISSN"}]},"item_10001_version_type_20":{"attribute_name":"出版タイプ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_be7fb7dd8ff6fe43","subitem_version_type":"NA"}]},"item_1714461018643":{"attribute_name":"報告番号","attribute_value_mlt":[{"subitem_dissertationnumber":"甲第3542号"}]},"item_1714461102074":{"attribute_name":"学位名","attribute_value_mlt":[{"subitem_degreename":"博士（歯学）","subitem_degreename_language":"ja"}]},"item_1714461118377":{"attribute_name":"学位授与年月日","attribute_value_mlt":[{"subitem_dategranted":"2021-09-09"}]},"item_1714461137393":{"attribute_name":"学位授与機関","attribute_value_mlt":[{"subitem_degreegrantor":[{"subitem_degreegrantor_language":"ja","subitem_degreegrantor_name":"徳島大学"}]}]},"item_1715043197608":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"open access"}]},"item_1718868208704":{"attribute_name":"備考","attribute_value_mlt":[{"subitem_textarea_language":"ja","subitem_textarea_value":"内容要旨・審査要旨・論文本文の公開\n本論文は，著者Junhel Dalanonの学位論文として提出され，学位審査・授与の対象となっている。\n学位授与者所属 : 徳島大学大学院口腔科学教育部（口腔科学専攻）"}]},"item_1718868303842":{"attribute_name":"学位記番号","attribute_value_mlt":[{"subitem_text_language":"ja","subitem_text_value":"甲口第473号"}]},"item_1722929371688":{"attribute_name":"出版社版DOI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_language":"ja","subitem_relation_name_text":"10.1038/s41598-021-93560-7"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://doi.org/10.1038/s41598-021-93560-7","subitem_relation_type_select":"DOI"}}]},"item_1723180141928":{"attribute_name":"EID","attribute_value_mlt":[{"subitem_identifier_type":"URI","subitem_identifier_uri":"376593"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"ダラノン, ジュネル カシニリヨ","creatorNameLang":"ja"},{"creatorName":"ダラノン, ジュネル カシニリヨ","creatorNameLang":"ja-Kana"},{"creatorName":"Dalanon, Junhel Casinillo","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"近久, 幸子","creatorNameLang":"ja"}],"nameIdentifiers":[{"nameIdentifier":"248","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"志内, 哲也","creatorNameLang":"ja"}],"nameIdentifiers":[{"nameIdentifier":"479","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"清水, 紀之","creatorNameLang":"ja"}],"nameIdentifiers":[{"nameIdentifier":"750","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Chavan, Parimal","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"鈴木, 善貴","creatorNameLang":"ja"}],"nameIdentifiers":[{"nameIdentifier":"706","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"大倉, 一夫","creatorNameLang":"ja"}],"nameIdentifiers":[{"nameIdentifier":"1689","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"勢井, 宏義","creatorNameLang":"ja"}],"nameIdentifiers":[{"nameIdentifier":"1549","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"松香, 芳三","creatorNameLang":"ja"}],"nameIdentifiers":[{"nameIdentifier":"589","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_access","date":[{"dateType":"Available","dateValue":"2021-10-06"}],"displaytype":"detail","filename":"k3542_abstract.pdf","filesize":[{"value":"120 KB"}],"format":"application/pdf","mimetype":"application/pdf","url":{"objectType":"abstract","url":"https://tokushima-u.repo.nii.ac.jp/record/2009059/files/k3542_abstract.pdf"},"version_id":"9f6296b3-340c-4744-b33f-d1ba081d52cc"},{"accessrole":"open_access","date":[{"dateType":"Available","dateValue":"2021-10-06"}],"displaytype":"detail","filename":"k3542_review.pdf","filesize":[{"value":"69.9 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stress","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Sleep","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Slow-wave activity","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Interleukin-6","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Tumor necrosis factor-alpha","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"doctoral thesis","resourceuri":"http://purl.org/coar/resource_type/c_db06"}]},"item_title":"Pain sensitivity increases with sleep disturbance under predictable chronic mild stress in mice","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Pain sensitivity increases with sleep disturbance under predictable chronic mild stress in mice","subitem_title_language":"en"}]},"item_type_id":"40001","owner":"7","path":["1716268556148"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2021-07-30"},"publish_date":"2021-07-30","publish_status":"0","recid":"2009059","relation_version_is_last":true,"title":["Pain sensitivity increases with sleep disturbance under predictable chronic mild stress in mice"],"weko_creator_id":"7","weko_shared_id":-1},"updated":"2024-12-12T01:12:31.290574+00:00"}