{"created":"2024-12-12T01:13:32.315278+00:00","id":2009073,"links":{},"metadata":{"_buckets":{"deposit":"f08fe9b3-0bf4-45ce-8575-10c70c55480d"},"_deposit":{"created_by":7,"id":"2009073","owners":[7],"pid":{"revision_id":0,"type":"depid","value":"2009073"},"status":"published"},"_oai":{"id":"oai:tokushima-u.repo.nii.ac.jp:02009073","sets":["1713853213384:1713853296295:1716267878536:1716268700025"]},"author_link":["324","782","1196","863"],"control_number":"2009073","item_10001_alternative_title_1":{"attribute_name":"タイトル別表記","attribute_value_mlt":[{"subitem_alternative_title":"ノビレチンは17型ヘルパーT細胞の分化調節により、実験的自己免疫性脳脊髄炎の発症を抑制する","subitem_alternative_title_language":"ja"}]},"item_10001_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2021-09-01","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"2","bibliographicPageEnd":"150","bibliographicPageStart":"145","bibliographicVolumeNumber":"69","bibliographic_titles":[{"bibliographic_title":"Journal of Clinical Biochemistry and Nutrition","bibliographic_titleLang":"en"}]}]},"item_10001_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Multiple sclerosis is an organ-specific autoimmune disease that targets the myelin antigen in the central nervous system. Nobiletin is a dietary polymethoxylated flavonoid found in citrus fruits. In this study, we investigated how nobiletin affects the disease state and immune responses to myelin oligodendrocyte glycoprotein in experimental autoimmune encephalomyelitis mice. Nobiletin was administered orally from 14 days before immunization until the end of the experiment, and clinical scores were determined. The production levels of interleukin-17A and interferon-γ were measured in a culture supernatant of splenocytes stimulated with myelin oligodendrocyte glycoprotein. In addition, flow cytometric analysis was performed to examine the effect of nobiletin on T cell differentiation in vitro. Admin­istration of nobiletin significantly decreased the clinical score and interleukin-17A production in splenocytes. Furthermore, in vitro analysis showed that nobiletin significantly suppressed Th17 cell differentiation and interleukin-17A production in a dose-dependent manner. The results suggest that nobiletin attenuates experimental autoimmune encephalomyelitis severity through modulation of Th17 cell differentiation.","subitem_description_language":"en","subitem_description_type":"Abstract"}]},"item_10001_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Society for Free Radical Research Japan","subitem_publisher_language":"en"}]},"item_10001_rights_15":{"attribute_name":"権利情報","attribute_value_mlt":[{"subitem_rights":"This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivatives License.","subitem_rights_language":"en"}]},"item_10001_source_id_9":{"attribute_name":"収録物ID","attribute_value_mlt":[{"subitem_source_identifier":"09120009","subitem_source_identifier_type":"ISSN"},{"subitem_source_identifier":"18805086","subitem_source_identifier_type":"ISSN"},{"subitem_source_identifier":"AA10710201","subitem_source_identifier_type":"NCID"}]},"item_10001_version_type_20":{"attribute_name":"出版タイプ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_be7fb7dd8ff6fe43","subitem_version_type":"NA"}]},"item_1714461018643":{"attribute_name":"報告番号","attribute_value_mlt":[{"subitem_dissertationnumber":"乙第2117号"}]},"item_1714461102074":{"attribute_name":"学位名","attribute_value_mlt":[{"subitem_degreename":"博士（栄養学）","subitem_degreename_language":"ja"}]},"item_1714461118377":{"attribute_name":"学位授与年月日","attribute_value_mlt":[{"subitem_dategranted":"2021-07-29"}]},"item_1714461137393":{"attribute_name":"学位授与機関","attribute_value_mlt":[{"subitem_degreegrantor":[{"subitem_degreegrantor_language":"ja","subitem_degreegrantor_name":"徳島大学"}]}]},"item_1715043197608":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"open access"}]},"item_1718868208704":{"attribute_name":"備考","attribute_value_mlt":[{"subitem_textarea_language":"ja","subitem_textarea_value":"内容要旨・審査要旨・論文本文の公開\n本論文は，著者Akiko Nakamotoの学位論文として提出され，学位審査・授与の対象となっている。"}]},"item_1718868303842":{"attribute_name":"学位記番号","attribute_value_mlt":[{"subitem_text_language":"ja","subitem_text_value":"乙栄第96号"}]},"item_1722929371688":{"attribute_name":"出版社版DOI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_language":"ja","subitem_relation_name_text":"10.3164/jcbn.20-178"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://doi.org/10.3164/jcbn.20-178","subitem_relation_type_select":"DOI"}}]},"item_1723180141928":{"attribute_name":"EID","attribute_value_mlt":[{"subitem_identifier_type":"URI","subitem_identifier_uri":"382896"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorAffiliations":[{"affiliationNameIdentifiers":[{"affiliationNameIdentifier":"","affiliationNameIdentifierScheme":"ISNI","affiliationNameIdentifierURI":"http://www.isni.org/isni/"}],"affiliationNames":[{"affiliationName":"","affiliationNameLang":"ja"}]}],"creatorNames":[{"creatorName":"中本, 晶子","creatorNameLang":"ja"},{"creatorName":"ナカモト, アキコ","creatorNameLang":"ja-Kana"},{"creatorName":"Nakamoto, Akiko","creatorNameLang":"en"}],"familyNames":[{"familyName":"中本","familyNameLang":"ja"},{"familyName":"ナカモト","familyNameLang":"ja-Kana"},{"familyName":"Nakamoto","familyNameLang":"en"}],"givenNames":[{"givenName":"晶子","givenNameLang":"ja"},{"givenName":"アキコ","givenNameLang":"ja-Kana"},{"givenName":"Akiko","givenNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"863","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"323760/profile-ja.html","nameIdentifierScheme":"徳島大学 教育研究者総覧","nameIdentifierURI":"http://pub2.db.tokushima-u.ac.jp/ERD/person/323760/profile-ja.html"},{"nameIdentifier":"90803536","nameIdentifierScheme":"e-Rad","nameIdentifierURI":"https://nrid.nii.ac.jp/ja/search/?qm=90803536"}]},{"creatorNames":[{"creatorName":"ヒラバヤシ, ユウワ","creatorNameLang":"ja"},{"creatorName":"ヒラバヤシ, ユウワ","creatorNameLang":"ja-Kana"},{"creatorName":"Hirabayashi, Yuwa","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"アンザキ, チエリ","creatorNameLang":"ja"},{"creatorName":"アンザキ, チエリ","creatorNameLang":"ja-Kana"},{"creatorName":"Anzaki, Chieri","creatorNameLang":"en"}]},{"creatorAffiliations":[{"affiliationNameIdentifiers":[{"affiliationNameIdentifier":"","affiliationNameIdentifierScheme":"ISNI","affiliationNameIdentifierURI":"http://www.isni.org/isni/"}],"affiliationNames":[{"affiliationName":"","affiliationNameLang":"ja"}]}],"creatorNames":[{"creatorName":"中本, 真理子","creatorNameLang":"ja"},{"creatorName":"ナカモト, マリコ","creatorNameLang":"ja-Kana"},{"creatorName":"Nakamoto, Mariko","creatorNameLang":"en"}],"familyNames":[{"familyName":"中本","familyNameLang":"ja"},{"familyName":"ナカモト","familyNameLang":"ja-Kana"},{"familyName":"Nakamoto","familyNameLang":"en"}],"givenNames":[{"givenName":"真理子","givenNameLang":"ja"},{"givenName":"マリコ","givenNameLang":"ja-Kana"},{"givenName":"Mariko","givenNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"782","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"293911/profile-ja.html","nameIdentifierScheme":"徳島大学 教育研究者総覧","nameIdentifierURI":"http://pub2.db.tokushima-u.ac.jp/ERD/person/293911/profile-ja.html"},{"nameIdentifier":"40722533","nameIdentifierScheme":"e-Rad","nameIdentifierURI":"https://nrid.nii.ac.jp/ja/search/?qm=40722533"}]},{"creatorAffiliations":[{"affiliationNameIdentifiers":[{"affiliationNameIdentifier":"","affiliationNameIdentifierScheme":"ISNI","affiliationNameIdentifierURI":"http://www.isni.org/isni/"}],"affiliationNames":[{"affiliationName":"","affiliationNameLang":"ja"}]}],"creatorNames":[{"creatorName":"首藤, 恵泉","creatorNameLang":"ja"},{"creatorName":"シュトウ, エミ","creatorNameLang":"ja-Kana"},{"creatorName":"Shuto, Emi","creatorNameLang":"en"}],"familyNames":[{"familyName":"首藤","familyNameLang":"ja"},{"familyName":"シュトウ","familyNameLang":"ja-Kana"},{"familyName":"Shuto","familyNameLang":"en"}],"givenNames":[{"givenName":"恵泉","givenNameLang":"ja"},{"givenName":"エミ","givenNameLang":"ja-Kana"},{"givenName":"Emi","givenNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"324","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"10512121","nameIdentifierScheme":"e-Rad","nameIdentifierURI":"https://nrid.nii.ac.jp/ja/search/?qm=10512121"}]},{"creatorAffiliations":[{"affiliationNameIdentifiers":[{"affiliationNameIdentifier":"","affiliationNameIdentifierScheme":"ISNI","affiliationNameIdentifierURI":"http://www.isni.org/isni/"}],"affiliationNames":[{"affiliationName":"","affiliationNameLang":"ja"}]}],"creatorNames":[{"creatorName":"酒井, 徹","creatorNameLang":"ja"},{"creatorName":"サカイ, トオル","creatorNameLang":"ja-Kana"},{"creatorName":"Sakai, Tohru","creatorNameLang":"en"}],"familyNames":[{"familyName":"酒井","familyNameLang":"ja"},{"familyName":"サカイ","familyNameLang":"ja-Kana"},{"familyName":"Sakai","familyNameLang":"en"}],"givenNames":[{"givenName":"徹","givenNameLang":"ja"},{"givenName":"トオル","givenNameLang":"ja-Kana"},{"givenName":"Tohru","givenNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"1196","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"60693/profile-ja.html","nameIdentifierScheme":"徳島大学 教育研究者総覧","nameIdentifierURI":"http://pub2.db.tokushima-u.ac.jp/ERD/person/60693/profile-ja.html"},{"nameIdentifier":"40274196","nameIdentifierScheme":"e-Rad","nameIdentifierURI":"https://nrid.nii.ac.jp/ja/search/?qm=40274196"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_access","date":[{"dateType":"Available","dateValue":"2021-08-05"}],"displaytype":"detail","filename":"o2117_abstract_review.pdf","filesize":[{"value":"192 KB"}],"format":"application/pdf","mimetype":"application/pdf","url":{"objectType":"abstract","url":"https://tokushima-u.repo.nii.ac.jp/record/2009073/files/o2117_abstract_review.pdf"},"version_id":"8185bce9-7082-4821-b87e-f5d505a11cbc"},{"accessrole":"open_access","date":[{"dateType":"Available","dateValue":"2021-09-01"}],"displaytype":"detail","filename":"o2117_fulltext.pdf","filesize":[{"value":"345 KB"}],"format":"application/pdf","licensetype":"license_5","mimetype":"application/pdf","url":{"objectType":"fulltext","url":"https://tokushima-u.repo.nii.ac.jp/record/2009073/files/o2117_fulltext.pdf"},"version_id":"0dd378ae-9529-4695-b5a9-f245e9bfd872"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"experimental autoimmune encephalomyelitis","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"nobiletin","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"polymethoxyflavonoid","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Th17 differentiation","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"IL-17A","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"polymethoxyflavone","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"doctoral thesis","resourceuri":"http://purl.org/coar/resource_type/c_db06"}]},"item_title":"Nobiletin suppresses the development of experimental autoimmune encephalomyelitis mediated by modulation of T helper 17 cell differentiation","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Nobiletin suppresses the development of experimental autoimmune encephalomyelitis mediated by modulation of T helper 17 cell differentiation","subitem_title_language":"en"}]},"item_type_id":"40001","owner":"7","path":["1716268700025"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2021-08-05"},"publish_date":"2021-08-05","publish_status":"0","recid":"2009073","relation_version_is_last":true,"title":["Nobiletin suppresses the development of experimental autoimmune encephalomyelitis mediated by modulation of T helper 17 cell differentiation"],"weko_creator_id":"7","weko_shared_id":-1},"updated":"2025-01-31T05:26:19.410743+00:00"}