{"created":"2024-12-12T01:17:32.087167+00:00","id":2009127,"links":{},"metadata":{"_buckets":{"deposit":"f9092f9d-af44-4c3a-bc1d-a5ad7c3e16b7"},"_deposit":{"created_by":7,"id":"2009127","owners":[7],"pid":{"revision_id":0,"type":"depid","value":"2009127"},"status":"published"},"_oai":{"id":"oai:tokushima-u.repo.nii.ac.jp:02009127","sets":["1713853213384:1713853295607"]},"author_link":["424","1192"],"control_number":"2009127","item_10001_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2020-11-13","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"12","bibliographicPageEnd":"4843","bibliographicPageStart":"4826","bibliographicVolumeNumber":"19","bibliographic_titles":[{"bibliographic_title":"Journal of Proteome Research","bibliographic_titleLang":"en"}]}]},"item_10001_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"The Human Proteome Project (HPP) consortium aims to functionally characterize the dark proteome. On the basis of the relevance of olfaction in early neurodegeneration, we have analyzed the dark proteome using data mining in public resources and omics data sets derived from the human olfactory system. Multiple dark proteins localize at synaptic terminals and may be involved in amyloidopathies such as Alzheimer’s disease (AD). We have characterized the dark PITH domain-containing protein 1 (PITHD1) in olfactory metabolism using bioinformatics, proteomics, in vitro and in vivo studies, and neuropathology. PITHD1–/– mice exhibit olfactory bulb (OB) proteome changes related to synaptic transmission, cognition, and memory. OB PITHD1 expression increases with age in wild-type (WT) mice and decreases in Tg2576 AD mice at late stages. The analysis across 6 neurological disorders reveals that olfactory tract (OT) PITHD1 is specifically upregulated in human AD. Stimulation of olfactory neuroepithelial (ON) cells with PITHD1 alters the ON phosphoproteome, modifies the proliferation rate, and induces a pro-inflammatory phenotype. This workflow applied by the Spanish C-HPP and Human Brain Proteome Project (HBPP) teams across the ON-OB-OT axis can be adapted as a guidance to decipher functional features of dark proteins. Data are available via ProteomeXchange with identifiers PXD018784 and PXD021634.","subitem_description_language":"en","subitem_description_type":"Abstract"}]},"item_10001_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"ACS Publications","subitem_publisher_language":"en"}]},"item_10001_rights_15":{"attribute_name":"権利情報","attribute_value_mlt":[{"subitem_rights":"This is an open access article published under a Creative Commons Non-Commercial No Derivative Works (CC-BY-NC-ND) Attribution License, which permits copying and redistribution of the article, and creation of adaptations, all for non-commercial purposes.","subitem_rights_language":"en"}]},"item_10001_source_id_9":{"attribute_name":"収録物ID","attribute_value_mlt":[{"subitem_source_identifier":"15353893","subitem_source_identifier_type":"ISSN"},{"subitem_source_identifier":"15353907","subitem_source_identifier_type":"ISSN"},{"subitem_source_identifier":"AA11638846","subitem_source_identifier_type":"NCID"},{"subitem_source_identifier":"AA12442770","subitem_source_identifier_type":"NCID"}]},"item_10001_version_type_20":{"attribute_name":"出版タイプ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_1715043197608":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"open 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Mikel","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Iloro, Ibon","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Elortza, Felix","creatorNameLang":"en"}]},{"creatorAffiliations":[{"affiliationNameIdentifiers":[{"affiliationNameIdentifier":"","affiliationNameIdentifierScheme":"ISNI","affiliationNameIdentifierURI":"http://www.isni.org/isni/"}],"affiliationNames":[{"affiliationName":"","affiliationNameLang":"ja"}]}],"creatorNames":[{"creatorName":"近藤, 博之","creatorNameLang":"ja"},{"creatorName":"コンドウ, ヒロユキ","creatorNameLang":"ja-Kana"},{"creatorName":"Kondo, Hiroyuki","creatorNameLang":"en"}],"familyNames":[{"familyName":"近藤","familyNameLang":"ja"},{"familyName":"コンドウ","familyNameLang":"ja-Kana"},{"familyName":"Kondo","familyNameLang":"en"}],"givenNames":[{"givenName":"博之","givenNameLang":"ja"},{"givenName":"ヒロユキ","givenNameLang":"ja-Kana"},{"givenName":"Hiroyuki","givenNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"1192","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"371775/profile-ja.html","nameIdentifierScheme":"徳島大学 教育研究者総覧","nameIdentifierURI":"http://pub2.db.tokushima-u.ac.jp/ERD/person/371775/profile-ja.html"}]},{"creatorAffiliations":[{"affiliationNameIdentifiers":[{"affiliationNameIdentifier":"","affiliationNameIdentifierScheme":"ISNI","affiliationNameIdentifierURI":"http://www.isni.org/isni/"}],"affiliationNames":[{"affiliationName":"","affiliationNameLang":"ja"}]}],"creatorNames":[{"creatorName":"大東, いずみ","creatorNameLang":"ja"},{"creatorName":"オオヒガシ, イズミ","creatorNameLang":"ja-Kana"},{"creatorName":"Ohigashi, 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Joaquín","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Santamaría, Enrique","creatorNameLang":"en"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_access","date":[{"dateType":"Available","dateValue":"2021-09-01"}],"displaytype":"detail","filename":"jproteome_19_12_4826.pdf","filesize":[{"value":"11.8 MB"}],"format":"application/pdf","licensetype":"license_5","mimetype":"application/pdf","url":{"objectType":"fulltext","url":"https://tokushima-u.repo.nii.ac.jp/record/2009127/files/jproteome_19_12_4826.pdf"},"version_id":"f4f8e5b9-b9f1-4704-8f51-8f524b4062e0"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"Human Proteome Project","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"olfaction","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"neurodegeneration","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"uPE1","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"dark proteome","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"PITHD1","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Smelling the Dark Proteome : Functional Characterization of PITH Domain-Containing Protein 1 (C1orf128) in Olfactory 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