{"created":"2024-12-12T01:20:54.406177+00:00","id":2009175,"links":{},"metadata":{"_buckets":{"deposit":"edff42f2-a0b7-4694-ba49-78cd3dd6a86d"},"_deposit":{"created_by":7,"id":"2009175","owners":[7],"pid":{"revision_id":0,"type":"depid","value":"2009175"},"status":"published"},"_oai":{"id":"oai:tokushima-u.repo.nii.ac.jp:02009175","sets":["1713853213384:1713853295607"]},"author_link":["1562","1248"],"control_number":"2009175","item_10001_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2020-10-28","bibliographicIssueDateType":"Issued"},"bibliographicPageStart":"18499","bibliographicVolumeNumber":"10","bibliographic_titles":[{"bibliographic_title":"Scientific Reports","bibliographic_titleLang":"en"}]}]},"item_10001_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"There are few studies examining the association between homocysteine (Hcy) level and the risk of hypertension with consideration for folate and vitamin B12 as related to Hcy level. We simultaneously examined the associations of plasma levels of Hcy, folate, and vitamin B12, and dietary folate intake with the prevalence of hypertension. Participants included 1046 men and 1033 women (mean age ± standard deviation: 56.0 ± 8.9 years) in the Japan Multi-Institutional Collaborative Cohort Study. Dietary folate intake was estimated using a validated food frequency questionnaire. Hypertension was defined based on measured blood pressure and use of antihypertensive medication. A total of 734 participants (35.3%) had hypertension. Multivariate-adjusted odds ratios of hypertension for the highest quartile group of Hcy were 2.36 (95% CI 1.41–3.96) in men and 1.86 (95% CI 1.11–3.11) in women, as compared with the lowest group (P for trend = 0.014 and 0.005, respectively). Dietary folate intake was not correlated with hypertension in both men and women (P for trend = 0.099 and 0.703, respectively). Plasma vitamin B12 was positively associated with hypertension only in women (P for trend = 0.027). Plasma Hcy level was positively linked with hypertension after controlling for covariates, including folate and vitamin B12.","subitem_description_language":"en","subitem_description_type":"Abstract"}]},"item_10001_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Springer Nature","subitem_publisher_language":"en"}]},"item_10001_rights_15":{"attribute_name":"権利情報","attribute_value_mlt":[{"subitem_rights":"This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.","subitem_rights_language":"en"}]},"item_10001_source_id_9":{"attribute_name":"収録物ID","attribute_value_mlt":[{"subitem_source_identifier":"20452322","subitem_source_identifier_type":"ISSN"}]},"item_10001_version_type_20":{"attribute_name":"出版タイプ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_1715043197608":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"open access"}]},"item_1722929371688":{"attribute_name":"出版社版DOI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_language":"ja","subitem_relation_name_text":"10.1038/s41598-020-75267-3"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://doi.org/10.1038/s41598-020-75267-3","subitem_relation_type_select":"DOI"}}]},"item_1723180141928":{"attribute_name":"EID","attribute_value_mlt":[{"subitem_identifier_type":"URI","subitem_identifier_uri":"373039"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"タムラ, タカシ","creatorNameLang":"ja"},{"creatorName":"タムラ, タカシ","creatorNameLang":"ja-Kana"},{"creatorName":"Tamura, Takashi","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"クリヤマ, ナガト","creatorNameLang":"ja"},{"creatorName":"クリヤマ, ナガト","creatorNameLang":"ja-Kana"},{"creatorName":"Kuriyama, Nagato","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"コヤマ, テルヒデ","creatorNameLang":"ja"},{"creatorName":"コヤマ, テルヒデ","creatorNameLang":"ja-Kana"},{"creatorName":"Koyama, Teruhide","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"オザキ, エツコ","creatorNameLang":"ja"},{"creatorName":"オザキ, エツコ","creatorNameLang":"ja-Kana"},{"creatorName":"Ozaki, Etsuko","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"マツイ, ダイスケ","creatorNameLang":"ja"},{"creatorName":"マツイ, ダイスケ","creatorNameLang":"ja-Kana"},{"creatorName":"Matsui, Daisuke","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"カドマツ, ユカ","creatorNameLang":"ja"},{"creatorName":"カドマツ, ユカ","creatorNameLang":"ja-Kana"},{"creatorName":"Kadomatsu, Yuka","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"ツカモト, ミネコ","creatorNameLang":"ja"},{"creatorName":"ツカモト, ミネコ","creatorNameLang":"ja-Kana"},{"creatorName":"Tsukamoto, Mineko","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"クボ, ヨウコ","creatorNameLang":"ja"},{"creatorName":"クボ, 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study","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Association between plasma levels of homocysteine, folate, and vitamin B12, and dietary folate intake and hypertension in a cross-sectional study","subitem_title_language":"en"}]},"item_type_id":"40001","owner":"7","path":["1713853295607"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2021-09-08"},"publish_date":"2021-09-08","publish_status":"0","recid":"2009175","relation_version_is_last":true,"title":["Association between plasma levels of homocysteine, folate, and vitamin B12, and dietary folate intake and hypertension in a cross-sectional study"],"weko_creator_id":"7","weko_shared_id":-1},"updated":"2025-02-14T00:18:48.767976+00:00"}