| Item type |
文献 / Documents(1) |
| 公開日 |
2021-09-10 |
| アクセス権 |
|
|
アクセス権 |
open access |
| 資源タイプ |
|
|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
|
資源タイプ |
journal article |
| 出版社版DOI |
|
|
|
関連識別子 |
https://doi.org/10.18632/aging.102322 |
|
|
関連名称 |
10.18632/aging.102322 |
| 出版タイプ |
|
|
出版タイプ |
VoR |
|
出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
| タイトル |
|
|
タイトル |
Involvement of adiponectin in age-related increases in tear production in mice |
| 著者 |
四釜, 洋介
クロサワ, ミエ
フルカワ, マサエ
石丸, 直澄
マツシタ, ケンジ
|
| 抄録 |
|
|
内容記述 |
Common age-related changes in the human eye contribute to the development of dry eye, including decreases in aqueous tear production. Although the infiltration of lymphocytes into the lacrimal glands occurs with age, age-related increases in tear production have also been observed in mice; however, the mechanisms underlying this increase remain unclear. We herein demonstrated that increases in tear production were not dependent on body weight gain or systemic conditions, such as insulin resistance, using aged mice and high-fat diet-fed mice. The results obtained also showed that senescence-associated T (SA-T) cells accumulated in the lacrimal glands of aged mice, particularly females. Expression levels of the nuclear transcription factor peroxisome proliferator-activated receptor-γ (PPARγ) in whole lacrimal glands and epithelial cells isolated from lacrimal glands were significantly higher in aged mice than in young mice. The expression levels of adiponectin and one of its receptors, AdipoR2, also increased in the lacrimal glands of aged mice, but not in those of high-fat diet-fed mice. Collectively, the present results indicate that PPARγ and adiponectin-mediated signaling contribute to age-related increases in tear production in mice and have potential as therapeutic targets for the treatment of dry eye in humans. |
| キーワード |
|
|
主題 |
dry eye |
| キーワード |
|
|
主題 |
adiponectin |
| キーワード |
|
|
主題 |
peroxisome proliferator-activated receptor gamma |
| キーワード |
|
|
主題 |
senescence-associated T cells |
| キーワード |
|
|
主題 |
aging |
| 書誌情報 |
en : Aging
巻 11,
号 19,
p. 8329-8346,
発行日 2019-10-08
|
| 収録物ID |
|
|
収録物識別子タイプ |
ISSN |
|
収録物識別子 |
19454589 |
| 出版者 |
|
|
出版者 |
Impact Journals |
| 権利情報 |
|
|
権利情報 |
This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY 3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
| EID |
|
|
識別子 |
368631 |
| 言語 |
|
|
言語 |
eng |
aging_11_19_8329.pdf (2.67 MB)
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