{"created":"2024-12-12T01:23:21.622772+00:00","id":2009206,"links":{},"metadata":{"_buckets":{"deposit":"63619009-5ade-417e-b4a5-17a2c42a9292"},"_deposit":{"created_by":7,"id":"2009206","owners":[7],"pid":{"revision_id":0,"type":"depid","value":"2009206"},"status":"published"},"_oai":{"id":"oai:tokushima-u.repo.nii.ac.jp:02009206","sets":["1713853213384:1713853296295:1716267877313:1716268556148"]},"author_link":["982","872","589","851","323"],"item_10001_alternative_title_1":{"attribute_name":"タイトル別表記","attribute_value_mlt":[{"subitem_alternative_title":"低出力超音波パルスは坐骨神経部分結紮によって引き起こされる神経障害性疼痛をマクロファージ極性制御を介して改善する","subitem_alternative_title_language":"ja"},{"subitem_alternative_title":"Ultrasound Ameliorates Neuropathic Pain","subitem_alternative_title_language":"en"}]},"item_10001_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2021-09-08","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"1","bibliographicPageEnd":"18","bibliographicPageStart":"11","bibliographicVolumeNumber":"34","bibliographic_titles":[{"bibliographic_title":"Journal of Oral Health and Biosciences","bibliographic_titleLang":"en"}]}]},"item_10001_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Inflammatory (M1-polarized) macrophages cause neuropathic pain (NP) after nerve injury through non-resolving neuroinflammation. However, increasing evidence suggests that converting M1 to anti-inflammatory M2 macrophages may rescue NP. In the present study, the therapeutic potential of low-intensity pulsed ultrasound (LIPUS) was investigated in a partial sciatic nerve ligation (PSL)-induced NP model.\nMaterials and Methods: Abnormal pain sensation, such as tactile allodynia, was caused by PSL. Immediately after PSL induction, the mice were subjected to LIPUS treatment for 20 min/day for 7 days. LIPUS was used at an average intensity of 60 mW/cm2 and a frequency of 1.5 MHz.\nResults: In the behavioral test, the LIPUS group showed a significant improvement in the PSL-induced hypersensitivity compared to the PSL group not exposed to LIPUS. We found an increasing number of M2 macrophages in the injured sciatic nerves after LIPUS exposure. LIPUS treatment decreased expression of pro-inflammatory microglial markers in spinal cord.\nConclusions: Our data suggest that LIPUS has an anti-nociceptive effect by increasing anti-inflammatory M2 macrophage and may be a suitable therapeutic candidate for NP.","subitem_description_language":"en","subitem_description_type":"Abstract"}]},"item_10001_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"四国歯学会","subitem_publisher_language":"ja"}]},"item_10001_source_id_9":{"attribute_name":"収録物ID","attribute_value_mlt":[{"subitem_source_identifier":"21896682","subitem_source_identifier_type":"ISSN"}]},"item_10001_version_type_20":{"attribute_name":"出版タイプ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_be7fb7dd8ff6fe43","subitem_version_type":"NA"}]},"item_1714461018643":{"attribute_name":"報告番号","attribute_value_mlt":[{"subitem_dissertationnumber":"甲第3543号"}]},"item_1714461102074":{"attribute_name":"学位名","attribute_value_mlt":[{"subitem_degreename":"博士（歯学）","subitem_degreename_language":"ja"}]},"item_1714461118377":{"attribute_name":"学位授与年月日","attribute_value_mlt":[{"subitem_dategranted":"2021-09-09"}]},"item_1714461137393":{"attribute_name":"学位授与機関","attribute_value_mlt":[{"subitem_degreegrantor":[{"subitem_degreegrantor_language":"ja","subitem_degreegrantor_name":"徳島大学"}]}]},"item_1715043197608":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"open access"}]},"item_1718868208704":{"attribute_name":"備考","attribute_value_mlt":[{"subitem_textarea_language":"ja","subitem_textarea_value":"内容要旨・審査要旨・論文本文の公開\n本論文は，著者Yao LIUの学位論文として提出され，学位審査・授与の対象となっている。\n学位授与者所属 : 徳島大学大学院口腔科学教育部（口腔科学専攻）"}]},"item_1718868303842":{"attribute_name":"学位記番号","attribute_value_mlt":[{"subitem_text_language":"ja","subitem_text_value":"甲口第474号"}]},"item_1722929371688":{"attribute_name":"出版社版DOI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_language":"ja","subitem_relation_name_text":"10.20738/johb.34.1_11"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://doi.org/10.20738/johb.34.1_11","subitem_relation_type_select":"DOI"}}]},"item_1723180141928":{"attribute_name":"EID","attribute_value_mlt":[{"subitem_identifier_type":"URI","subitem_identifier_uri":"381779"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"リュウ, ヤオ","creatorNameLang":"ja"},{"creatorName":"リュウ, ヤオ","creatorNameLang":"ja-Kana"},{"creatorName":"Liu, Yao","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Xia, Linze","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"加納, 史也","creatorNameLang":"ja"}],"nameIdentifiers":[{"nameIdentifier":"982","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"橋本, 登","creatorNameLang":"ja"}],"nameIdentifiers":[{"nameIdentifier":"872","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"松香, 芳三","creatorNameLang":"ja"}],"nameIdentifiers":[{"nameIdentifier":"589","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"山本, 朗仁","creatorNameLang":"ja"}],"nameIdentifiers":[{"nameIdentifier":"851","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"田中, 栄二","creatorNameLang":"ja"}],"nameIdentifiers":[{"nameIdentifier":"323","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_access","date":[{"dateType":"Available","dateValue":"2021-10-06"}],"displaytype":"detail","filename":"k3543_abstract.pdf","filesize":[{"value":"153 KB"}],"format":"application/pdf","mimetype":"application/pdf","url":{"objectType":"abstract","url":"https://tokushima-u.repo.nii.ac.jp/record/2009206/files/k3543_abstract.pdf"},"version_id":"ca09775b-cccf-4514-94fd-71aab34a6a75"},{"accessrole":"open_access","date":[{"dateType":"Available","dateValue":"2021-10-06"}],"displaytype":"detail","filename":"k3543_review.pdf","filesize":[{"value":"56.7 KB"}],"format":"application/pdf","mimetype":"application/pdf","url":{"objectType":"other","url":"https://tokushima-u.repo.nii.ac.jp/record/2009206/files/k3543_review.pdf"},"version_id":"c1c88ac5-a973-42e9-9fe8-eeb3d669c5a8"},{"accessrole":"open_access","date":[{"dateType":"Available","dateValue":"2021-10-06"}],"displaytype":"detail","filename":"k3543_fulltext.pdf","filesize":[{"value":"3.05 MB"}],"format":"application/pdf","mimetype":"application/pdf","url":{"objectType":"fulltext","url":"https://tokushima-u.repo.nii.ac.jp/record/2009206/files/k3543_fulltext.pdf"},"version_id":"582d887d-3eeb-43a9-94fe-35fe530305ec"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"Neuropathic pain","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Low-intensity pulsed ultrasound","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Macrophages","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Anti-inflammation","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"doctoral thesis","resourceuri":"http://purl.org/coar/resource_type/c_db06"}]},"item_title":"Low-Intensity Pulsed Ultrasound Ameliorates Neuropathic Pain Induced by Partial Sciatic Nerve Ligation Via Regulating Macrophage Polarization","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Low-Intensity Pulsed Ultrasound Ameliorates Neuropathic Pain Induced by Partial Sciatic Nerve Ligation Via Regulating Macrophage Polarization","subitem_title_language":"en"}]},"item_type_id":"40001","owner":"7","path":["1716268556148"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2021-09-09"},"publish_date":"2021-09-09","publish_status":"0","recid":"2009206","relation_version_is_last":true,"title":["Low-Intensity Pulsed Ultrasound Ameliorates Neuropathic Pain Induced by Partial Sciatic Nerve Ligation Via Regulating Macrophage Polarization"],"weko_creator_id":"7","weko_shared_id":-1},"updated":"2024-12-12T01:23:30.567341+00:00"}