{"created":"2024-12-12T01:24:37.116181+00:00","id":2009221,"links":{},"metadata":{"_buckets":{"deposit":"8a7a5763-365f-436f-8dcb-8beb9724d90b"},"_deposit":{"created_by":7,"id":"2009221","owners":[7],"pid":{"revision_id":0,"type":"depid","value":"2009221"},"status":"published"},"_oai":{"id":"oai:tokushima-u.repo.nii.ac.jp:02009221","sets":["1713853213384:1713853295607"]},"author_link":["1145","828"],"control_number":"2009221","item_10001_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2018-09-01","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"3","bibliographicPageEnd":"150","bibliographicPageStart":"137","bibliographicVolumeNumber":"1","bibliographic_titles":[{"bibliographic_title":"FASEB BioAdvances","bibliographic_titleLang":"en"}]}]},"item_10001_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Alpha-1-acid glycoprotein (AGP) is a major acute-phase protein. Biosynthesis of AGP increases markedly during inflammation and infection, similar to nitric oxide (NO) biosynthesis. AGP variant A (AGP) contains a reduced cysteine (Cys149). Previously, we reported that S-nitrosated AGP (SNO-AGP) synthesized by reaction with a NO donor, possessed very strong broad-spectrum antimicrobial activity (IC50 = 10−9-10−6 M). In this study, using a cecal ligation and puncture animal model, we confirmed that AGP can be endogenously S-nitrosated during infection. Furthermore, we examined the antibacterial property of SNO-AGP against multidrug-resistant Klebsiella pneumoniae and Pseudomonas aeruginosa to investigate the involvement of SNO-AGP in the host defense system. Our results showed that SNO-AGP could inhibit multidrug efflux pump, AcrAB-TolC, a major contributor to bacterial multidrug resistance. In addition, SNO-AGP decreased biofilm formation and ATP level in bacteria, indicating that SNO-AGP can revert drug resistance. It was also noteworthy that SNO-AGP showed synergistic effects with the existing antibiotics (oxacillin, imipenem, norfloxacin, erythromycin, and tetracycline). In conclusion, SNO-AGP participated in the host defense system and has potential as a novel agent for single or combination antimicrobial therapy.","subitem_description_language":"en","subitem_description_type":"Abstract"}]},"item_10001_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Federation of American Societies for Experimental Biology","subitem_publisher_language":"en"},{"subitem_publisher":"Wiley","subitem_publisher_language":"en"}]},"item_10001_rights_15":{"attribute_name":"権利情報","attribute_value_mlt":[{"subitem_rights":"This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.","subitem_rights_language":"en"}]},"item_10001_source_id_9":{"attribute_name":"収録物ID","attribute_value_mlt":[{"subitem_source_identifier":"25739832","subitem_source_identifier_type":"ISSN"}]},"item_10001_version_type_20":{"attribute_name":"出版タイプ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_1715043197608":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"open access"}]},"item_1722929371688":{"attribute_name":"出版社版DOI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_language":"ja","subitem_relation_name_text":"10.1096/fba.1018"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://doi.org/10.1096/fba.1018","subitem_relation_type_select":"DOI"}}]},"item_1723180141928":{"attribute_name":"EID","attribute_value_mlt":[{"subitem_identifier_type":"URI","subitem_identifier_uri":"345876"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorAffiliations":[{"affiliationNameIdentifiers":[{"affiliationNameIdentifier":"","affiliationNameIdentifierScheme":"ISNI","affiliationNameIdentifierURI":"http://www.isni.org/isni/"}],"affiliationNames":[{"affiliationName":"","affiliationNameLang":"ja"}]}],"creatorNames":[{"creatorName":"異島, 優","creatorNameLang":"ja"},{"creatorName":"イシマ, ユウ","creatorNameLang":"ja-Kana"},{"creatorName":"Ishima, Yu","creatorNameLang":"en"}],"familyNames":[{"familyName":"異島","familyNameLang":"ja"},{"familyName":"イシマ","familyNameLang":"ja-Kana"},{"familyName":"Ishima","familyNameLang":"en"}],"givenNames":[{"givenName":"優","givenNameLang":"ja"},{"givenName":"ユウ","givenNameLang":"ja-Kana"},{"givenName":"Yu","givenNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"828","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"310655/profile-ja.html","nameIdentifierScheme":"徳島大学 教育研究者総覧","nameIdentifierURI":"http://pub2.db.tokushima-u.ac.jp/ERD/person/310655/profile-ja.html"}]},{"creatorNames":[{"creatorName":"ワタナベ, カオリ","creatorNameLang":"ja"},{"creatorName":"ワタナベ, カオリ","creatorNameLang":"ja-Kana"},{"creatorName":"Watanabe, Kaori","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Chuang, Victor T. G.","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"タケダ, イヨ","creatorNameLang":"ja"},{"creatorName":"タケダ, イヨ","creatorNameLang":"ja-Kana"},{"creatorName":"Takeda, Iyo","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"クロダ, テルオ","creatorNameLang":"ja"},{"creatorName":"クロダ, テルオ","creatorNameLang":"ja-Kana"},{"creatorName":"Kuroda, Teruo","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"オガワ, ワカノ","creatorNameLang":"ja"},{"creatorName":"オガワ, ワカノ","creatorNameLang":"ja-Kana"},{"creatorName":"Ogawa, Wakano","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"ワタナベ, ヒロシ","creatorNameLang":"ja"},{"creatorName":"ワタナベ, ヒロシ","creatorNameLang":"ja-Kana"},{"creatorName":"Watanabe, Hiroshi","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"イワオ, ヤスノリ","creatorNameLang":"ja"},{"creatorName":"イワオ, ヤスノリ","creatorNameLang":"ja-Kana"},{"creatorName":"Iwao, Yasunori","creatorNameLang":"en"}]},{"creatorAffiliations":[{"affiliationNameIdentifiers":[{"affiliationNameIdentifier":"","affiliationNameIdentifierScheme":"ISNI","affiliationNameIdentifierURI":"http://www.isni.org/isni/"}],"affiliationNames":[{"affiliationName":"","affiliationNameLang":"ja"}]}],"creatorNames":[{"creatorName":"石田, 竜弘","creatorNameLang":"ja"},{"creatorName":"イシダ, タツヒロ","creatorNameLang":"ja-Kana"},{"creatorName":"Ishida, Tatsuhiro","creatorNameLang":"en"}],"familyNames":[{"familyName":"石田","familyNameLang":"ja"},{"familyName":"イシダ","familyNameLang":"ja-Kana"},{"familyName":"Ishida","familyNameLang":"en"}],"givenNames":[{"givenName":"竜弘","givenNameLang":"ja"},{"givenName":"タツヒロ","givenNameLang":"ja-Kana"},{"givenName":"Tatsuhiro","givenNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"1145","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"60644/profile-ja.html","nameIdentifierScheme":"徳島大学 教育研究者総覧","nameIdentifierURI":"http://pub2.db.tokushima-u.ac.jp/ERD/person/60644/profile-ja.html"},{"nameIdentifier":"50325271","nameIdentifierScheme":"e-Rad","nameIdentifierURI":"https://nrid.nii.ac.jp/ja/search/?qm=50325271"}]},{"creatorNames":[{"creatorName":"オタギリ, マサキ","creatorNameLang":"ja"},{"creatorName":"オタギリ, マサキ","creatorNameLang":"ja-Kana"},{"creatorName":"Otagiri, Masaki","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"マルヤマ, トオル","creatorNameLang":"ja"},{"creatorName":"マルヤマ, トオル","creatorNameLang":"ja-Kana"},{"creatorName":"Maruyama, Toru","creatorNameLang":"en"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_access","date":[{"dateType":"Available","dateValue":"2021-09-29"}],"displaytype":"detail","filename":"fba_1_3_137.pdf","filesize":[{"value":"1.43 MB"}],"format":"application/pdf","licensetype":"license_0","mimetype":"application/pdf","url":{"objectType":"fulltext","url":"https://tokushima-u.repo.nii.ac.jp/record/2009221/files/fba_1_3_137.pdf"},"version_id":"4bb6645a-2a9f-4ec4-bd55-d2ddb64a8120"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"alpha‐1‐acid glycoprotein","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"antimicrobial effect","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"multidrug resistance","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"nitric oxide","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"S‐nitrosation","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"S-Nitrosated alpha-1-acid glycoprotein exhibits antibacterial activity against multidrug-resistant bacteria strains and synergistically enhances the effect of antibiotics","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"S-Nitrosated alpha-1-acid glycoprotein exhibits antibacterial activity against multidrug-resistant bacteria strains and synergistically enhances the effect of antibiotics","subitem_title_language":"en"}]},"item_type_id":"40001","owner":"7","path":["1713853295607"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2021-09-29"},"publish_date":"2021-09-29","publish_status":"0","recid":"2009221","relation_version_is_last":true,"title":["S-Nitrosated alpha-1-acid glycoprotein exhibits antibacterial activity against multidrug-resistant bacteria strains and synergistically enhances the effect of antibiotics"],"weko_creator_id":"7","weko_shared_id":-1},"updated":"2025-01-30T07:50:31.692847+00:00"}