{"created":"2024-12-12T01:26:31.984440+00:00","id":2009245,"links":{},"metadata":{"_buckets":{"deposit":"d25fee79-cebe-4020-bf61-2cfcd7634583"},"_deposit":{"created_by":7,"id":"2009245","owners":[7],"pid":{"revision_id":0,"type":"depid","value":"2009245"},"status":"published"},"_oai":{"id":"oai:tokushima-u.repo.nii.ac.jp:02009245","sets":["1713853213384:1713853295607"]},"author_link":["881","1703","1176","1257","862"],"item_10001_alternative_title_1":{"attribute_name":"タイトル別表記","attribute_value_mlt":[{"subitem_alternative_title":"Current status and future development of carbonate apatite as a bone substitute","subitem_alternative_title_language":"en"}]},"item_10001_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2021-08-25","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"2","bibliographicPageEnd":"95","bibliographicPageStart":"87","bibliographicVolumeNumber":"20","bibliographic_titles":[{"bibliographic_title":"日本顎顔面インプラント学会誌","bibliographic_titleLang":"ja"},{"bibliographic_title":"Japanese Journal of Maxillofacial Implants","bibliographic_titleLang":"en"}]}]},"item_10001_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"A main inorganic component of human bone is not hydroxyapatite but carbonate apatite (CQ3Ap). Hydroxyapatite is not resorbed in the body but C03Ap can be resorbed and replaced with bone. We have succeeded in fabricating low crystalline CQ3Ap without sintering by dissolution-precipitation reaction using calcium hydroxide as a precursor. C03Ap showed excellent biocompatibility and faster bone formation compared to other bone substitutes (anorganic bovine bone and hydroxyapatite) in rabbit femur and dog mandible. Clinical study on effectiveness and safety of C03Ap granules in sinus floor augmentation was successfully concluded in 2016. CQ3Ap granules were approved by Japanese government in 2017, and marketed in 2018 as Cytrans® Granules. This comprehensive review explains the clinical cases of sinus lift and alveolar ridge augmentation of Cytrans® and its recommended clinical usage. Furthermore, we have succeeded in developing porous C03Ap and showed it was useful for reconstruction of mandibular bone defect in rabbit model and also aim to use it as a scaffold for bone regenerative medicine.","subitem_description_language":"en","subitem_description_type":"Abstract"},{"subitem_description":"ヒトの骨の無機主成分はハイドロキシアパタイトではなく，炭酸アパタイト (CO3Ap) である．ハイドロキシアパタイトは体内で吸収されないが，CO3Apは吸収されて骨と置換する．われわれは水酸化カルシウムを前駆物質として，焼結操作を用いずに溶解析出反応によって低結晶性の炭酸アパタイトを人工合成することに成功した．炭酸アパタイ卜顆粒は，ウサギ大腿骨とイヌ顎骨における実験で，他の骨補填材よりも骨が速く形成すること，優れた生体親和性を示すことを明らかにした．2016年に上顎洞底挙上術での臨床治験を成功裏に終え，2017年に炭酸アパタイト顆粒は薬事承認され，2018年からサイトランス® グラニュールとして市販された本総説では，サイトランス® による上顎洞底挙上症例と歯槽堤造成術症例を紹介すると共に，その臨床的推奨使用法を説明した．さらに，著者らは多孔質の炭酸アパタイトの作製に成功し，炭酸アパタイト多孔体がウサギの下顎骨欠損モデルにおいて骨再建に有用であることを示した．現在，炭酸アパタイト多孔体の骨再生医療用スキャフォールドヘの応用を目指している．","subitem_description_language":"ja","subitem_description_type":"Abstract"}]},"item_10001_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"日本顎顔面インプラント学会","subitem_publisher_language":"ja"}]},"item_10001_source_id_9":{"attribute_name":"収録物ID","attribute_value_mlt":[{"subitem_source_identifier":"1347894X","subitem_source_identifier_type":"ISSN"},{"subitem_source_identifier":"24335509","subitem_source_identifier_type":"ISSN"},{"subitem_source_identifier":"AA11911311","subitem_source_identifier_type":"NCID"}]},"item_10001_version_type_20":{"attribute_name":"出版タイプ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_1715043197608":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"open 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