{"created":"2024-12-12T01:27:40.023899+00:00","id":2009260,"links":{},"metadata":{"_buckets":{"deposit":"1f6acb65-1ea4-4756-a3e8-bd3fe7c61a5f"},"_deposit":{"created_by":7,"id":"2009260","owners":[7],"pid":{"revision_id":0,"type":"depid","value":"2009260"},"status":"published"},"_oai":{"id":"oai:tokushima-u.repo.nii.ac.jp:02009260","sets":["1713853213384:1713853296295:1716267878536:1716268699858"]},"author_link":["866","1162","865","223","1180","1586"],"item_10001_alternative_title_1":{"attribute_name":"タイトル別表記","attribute_value_mlt":[{"subitem_alternative_title":"C2C12筋管細胞においてモリンはデキサメタゾン誘導性の酸化ストレスと筋萎縮を抑制する","subitem_alternative_title_language":"ja"}]},"item_10001_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2021-04-10","bibliographicIssueDateType":"Issued"},"bibliographicPageStart":"108873","bibliographicVolumeNumber":"704","bibliographic_titles":[{"bibliographic_title":"Archives of Biochemistry and Biophysics","bibliographic_titleLang":"en"}]}]},"item_10001_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Glucocorticoids are the drugs most commonly used to manage inflammatory diseases. However, they are prone to inducing muscle atrophy by increasing muscle proteolysis and decreasing protein synthesis. Various studies have demonstrated that antioxidants can mitigate glucocorticoid-induced skeletal muscle atrophy. Here, we investigated the effect of a potent antioxidative natural flavonoid, morin, on the muscle atrophy and oxidative stress induced by dexamethasone (Dex) using mouse C2C12 skeletal myotubes. Dex (10 μM) enhanced the production of reactive oxygen species (ROS) in C2C12 myotubes via glucocorticoid receptor. Moreover, Dex administration reduced the diameter and expression levels of the myosin heavy chain protein in C2C12 myotubes, together with the upregulation of muscle atrophy-associated ubiquitin ligases, such as muscle atrophy F-box protein 1/atrogin-1, muscle ring finger protein-1, and casitas B-lineage lymphoma proto-oncogene-b. Dex also significantly decreased phosphorylated Foxo3a and increased total Foxo3a expression. Interestingly, Dex-induced ROS accumulation and Foxo3a expression were inhibited by morin (10 μM) pretreatment. Morin also prevented the Dex-induced reduction of myotube thickness, together with muscle protein degradation and suppression of the upregulation of atrophy-associated ubiquitin ligases. In conclusion, our results suggest that morin effectively prevents glucocorticoid-induced muscle atrophy by reducing oxidative stress.","subitem_description_language":"en","subitem_description_type":"Abstract"}]},"item_10001_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Elsevier","subitem_publisher_language":"en"}]},"item_10001_rights_15":{"attribute_name":"権利情報","attribute_value_mlt":[{"subitem_rights":"© 2021 Elsevier Inc. All rights reserved.","subitem_rights_language":"en"}]},"item_10001_source_id_9":{"attribute_name":"収録物ID","attribute_value_mlt":[{"subitem_source_identifier":"00039861","subitem_source_identifier_type":"ISSN"},{"subitem_source_identifier":"AA00547159","subitem_source_identifier_type":"NCID"},{"subitem_source_identifier":"AA11539811","subitem_source_identifier_type":"NCID"}]},"item_10001_version_type_20":{"attribute_name":"出版タイプ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_be7fb7dd8ff6fe43","subitem_version_type":"NA"}]},"item_1714461018643":{"attribute_name":"報告番号","attribute_value_mlt":[{"subitem_dissertationnumber":"甲第3532号"}]},"item_1714461102074":{"attribute_name":"学位名","attribute_value_mlt":[{"subitem_degreename":"博士（栄養学）","subitem_degreename_language":"ja"}]},"item_1714461118377":{"attribute_name":"学位授与年月日","attribute_value_mlt":[{"subitem_dategranted":"2021-09-02"}]},"item_1714461137393":{"attribute_name":"学位授与機関","attribute_value_mlt":[{"subitem_degreegrantor":[{"subitem_degreegrantor_language":"ja","subitem_degreegrantor_name":"徳島大学"}]}]},"item_1715043197608":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"open access"}]},"item_1718868208704":{"attribute_name":"備考","attribute_value_mlt":[{"subitem_textarea_language":"ja","subitem_textarea_value":"内容要旨・審査要旨・論文本文の公開\n本論文は,著者Anayt Ullaの学位論文として提出され，学位審査・授与の対象となっている。\n著者名\"Anayt Ulla\"について，論文投稿時に著者姓・名が必須項目だったため，論文PDFでは便宜上 \"Anayt Ulla\" と表記されているが，実際には姓はなく，本名は \"Anaytulla\" である。\n学位授与者所属 : 徳島大学大学院栄養生命科学教育部（人間栄養科学専攻）"}]},"item_1718868303842":{"attribute_name":"学位記番号","attribute_value_mlt":[{"subitem_text_language":"ja","subitem_text_value":"甲栄286号"}]},"item_1722929371688":{"attribute_name":"出版社版DOI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_language":"ja","subitem_relation_name_text":"10.1016/j.abb.2021.108873"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://doi.org/10.1016/j.abb.2021.108873","subitem_relation_type_select":"DOI"}}]},"item_1723180141928":{"attribute_name":"EID","attribute_value_mlt":[{"subitem_identifier_type":"URI","subitem_identifier_uri":"387067"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"アナイットウラ","creatorNameLang":"ja"},{"creatorName":"アナイットウラ","creatorNameLang":"ja-Kana"},{"creatorName":"Anaytulla","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"内田, 貴之","creatorNameLang":"ja"}],"nameIdentifiers":[{"nameIdentifier":"866","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"ミキ, ユカリ","creatorNameLang":"ja"},{"creatorName":"ミキ, ユカリ","creatorNameLang":"ja-Kana"},{"creatorName":"Miki, Yukari","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"杉浦, 宏祐","creatorNameLang":"ja"}],"nameIdentifiers":[{"nameIdentifier":"1162","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"ヒガシタニ, アツシ","creatorNameLang":"ja"},{"creatorName":"ヒガシタニ, アツシ","creatorNameLang":"ja-Kana"},{"creatorName":"Higashitani, Atsushi","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"コバヤシ, タケシ","creatorNameLang":"ja"},{"creatorName":"コバヤシ, タケシ","creatorNameLang":"ja-Kana"},{"creatorName":"Kobayashi, Takeshi","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"オオノ, アヤコ","creatorNameLang":"ja"},{"creatorName":"オオノ, アヤコ","creatorNameLang":"ja-Kana"},{"creatorName":"Ohno, Ayako","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"中尾, 玲子","creatorNameLang":"ja"}],"nameIdentifiers":[{"nameIdentifier":"865","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"平坂, 勝也","creatorNameLang":"ja"}],"nameIdentifiers":[{"nameIdentifier":"223","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"榊原, 伊織","creatorNameLang":"ja"}],"nameIdentifiers":[{"nameIdentifier":"1180","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"二川, 健","creatorNameLang":"ja"}],"nameIdentifiers":[{"nameIdentifier":"1586","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_access","date":[{"dateType":"Available","dateValue":"2021-10-06"}],"displaytype":"detail","filename":"k3532_abstract_review.pdf","filesize":[{"value":"209 KB"}],"format":"application/pdf","mimetype":"application/pdf","url":{"objectType":"abstract","url":"https://tokushima-u.repo.nii.ac.jp/record/2009260/files/k3532_abstract_review.pdf"},"version_id":"26630f34-e483-4c13-a662-695e318b65f6"},{"accessrole":"open_access","date":[{"dateType":"Available","dateValue":"2021-10-06"}],"displaytype":"detail","filename":"k3532_fulltext.pdf","filesize":[{"value":"2.44 MB"}],"format":"application/pdf","mimetype":"application/pdf","url":{"objectType":"fulltext","url":"https://tokushima-u.repo.nii.ac.jp/record/2009260/files/k3532_fulltext.pdf"},"version_id":"2f8a6680-142b-43e7-8a17-ac4ba0e8520c"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"Muscle atrophy","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Morin","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Mouse C2C12 skeletal myotubes","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Reactive oxygen species","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Ubiquitin ligases","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"doctoral thesis","resourceuri":"http://purl.org/coar/resource_type/c_db06"}]},"item_title":"Morin attenuates dexamethasone-mediated oxidative stress and atrophy in mouse C2C12 skeletal myotubes","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Morin attenuates dexamethasone-mediated oxidative stress and atrophy in mouse C2C12 skeletal myotubes","subitem_title_language":"en"}]},"item_type_id":"40001","owner":"7","path":["1716268699858"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2021-10-06"},"publish_date":"2021-10-06","publish_status":"0","recid":"2009260","relation_version_is_last":true,"title":["Morin attenuates dexamethasone-mediated oxidative stress and atrophy in mouse C2C12 skeletal myotubes"],"weko_creator_id":"7","weko_shared_id":-1},"updated":"2024-12-12T01:27:49.282364+00:00"}