{"created":"2024-12-12T01:27:45.359632+00:00","id":2009261,"links":{},"metadata":{"_buckets":{"deposit":"dc048e63-ec4d-4874-a7d3-7b6d891d8965"},"_deposit":{"created_by":7,"id":"2009261","owners":[7],"pid":{"revision_id":0,"type":"depid","value":"2009261"},"status":"published"},"_oai":{"id":"oai:tokushima-u.repo.nii.ac.jp:02009261","sets":["1713853213384:1713853296295:1716267876683:1716268551628"]},"author_link":["924","908","939","310","989","756"],"item_10001_alternative_title_1":{"attribute_name":"タイトル別表記","attribute_value_mlt":[{"subitem_alternative_title":"細胞診における探針エレクトロスプレーイオン化質量分析の有用性 : 肺癌培養細胞での検討","subitem_alternative_title_language":"ja"},{"subitem_alternative_title":"PESI-MS for Diagnostic Cytology","subitem_alternative_title_language":"en"}]},"item_10001_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2021-06-07","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"5","bibliographicPageEnd":"439","bibliographicPageStart":"430","bibliographicVolumeNumber":"65","bibliographic_titles":[{"bibliographic_title":"Acta Cytologica","bibliographic_titleLang":"en"}]}]},"item_10001_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Objectives: Cytology and histology are 2 indispensable diagnostic tools for cancer diagnosis, which are rapidly increasing in importance with aging populations. We applied mass spectrometry (MS) as a rapid approach for swiftly acquiring nonmorphological information of interested cells. Conventional MS, which primarily rely on promoting ionization by pre-applying a matrix to cells, has the drawback of time-consuming both on data acquisition and analysis. As an emerging method, probe electrospray ionization-MS (PESI-MS) with a dedicated probe is capable to pierce sample and measure specimen in small amounts, either liquid or solid, without the requirement for sample pretreatment. Furthermore, PESI-MS is timesaving compared to the conventional MS. Herein, we investigated the capability of PESI-MS to characterize the cell types derived from the respiratory tract of human tissues. Study Design: PESI-MS analyses with DPiMS-2020 were performed on various type of cultured cells including 5 lung squamous cell carcinomas, 5 lung adenocarcinomas, 5 small-cell carcinomas, 4 malignant mesotheliomas, and 2 normal controls. Results: Several characteristic peaks were detected at around m/z 200 and 800 that were common in all samples. As expected, partial least squares-discriminant analysis of PESI-MS data distinguished the cancer cell types from normal control cells. Moreover, distinct clusters divided squamous cell carcinoma from adenocarcinoma. Conclusion: PESI-MS presented a promising potential as a novel diagnostic modality for swiftly acquiring specific cytological information.","subitem_description_language":"en","subitem_description_type":"Abstract"}]},"item_10001_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Karger","subitem_publisher_language":"en"}]},"item_10001_rights_15":{"attribute_name":"権利情報","attribute_value_mlt":[{"subitem_rights":"© 2021 S. Karger AG, Basel","subitem_rights_language":"en"}]},"item_10001_source_id_9":{"attribute_name":"収録物ID","attribute_value_mlt":[{"subitem_source_identifier":"00015547","subitem_source_identifier_type":"ISSN"},{"subitem_source_identifier":"19382650","subitem_source_identifier_type":"ISSN"},{"subitem_source_identifier":"AA00044384","subitem_source_identifier_type":"NCID"},{"subitem_source_identifier":"AA12780809","subitem_source_identifier_type":"NCID"}]},"item_10001_version_type_20":{"attribute_name":"出版タイプ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_be7fb7dd8ff6fe43","subitem_version_type":"NA"}]},"item_1714461018643":{"attribute_name":"報告番号","attribute_value_mlt":[{"subitem_dissertationnumber":"甲第3535号"}]},"item_1714461102074":{"attribute_name":"学位名","attribute_value_mlt":[{"subitem_degreename":"博士（医学）","subitem_degreename_language":"ja"}]},"item_1714461118377":{"attribute_name":"学位授与年月日","attribute_value_mlt":[{"subitem_dategranted":"2021-09-09"}]},"item_1714461137393":{"attribute_name":"学位授与機関","attribute_value_mlt":[{"subitem_degreegrantor":[{"subitem_degreegrantor_language":"ja","subitem_degreegrantor_name":"徳島大学"}]}]},"item_1715043197608":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"open access"}]},"item_1718868208704":{"attribute_name":"備考","attribute_value_mlt":[{"subitem_textarea_language":"ja","subitem_textarea_value":"内容要旨・審査要旨・論文本文の公開\n本論文は，著者Yuki Morimotoの学位論文として提出され，学位審査・授与の対象となっている。\n学位授与者所属 : 徳島大学大学院医科学教育部（医学専攻）"}]},"item_1718868303842":{"attribute_name":"学位記番号","attribute_value_mlt":[{"subitem_text_language":"ja","subitem_text_value":"甲医第1502号"}]},"item_1722929371688":{"attribute_name":"出版社版DOI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_language":"ja","subitem_relation_name_text":"10.1159/000516639"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://doi.org/10.1159/000516639","subitem_relation_type_select":"DOI"}}]},"item_1723180141928":{"attribute_name":"EID","attribute_value_mlt":[{"subitem_identifier_type":"URI","subitem_identifier_uri":"380927"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"森本, 友樹","creatorNameLang":"ja"},{"creatorName":"モリモト, ユウキ","creatorNameLang":"ja-Kana"},{"creatorName":"Morimoto, Yuki","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"尾矢, 剛志","creatorNameLang":"ja"}],"nameIdentifiers":[{"nameIdentifier":"924","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"(市村)清水, 真祐子","creatorNameLang":"ja"}],"nameIdentifiers":[{"nameIdentifier":"908","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"松本, 穣","creatorNameLang":"ja"}],"nameIdentifiers":[{"nameIdentifier":"939","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"小川, 博久","creatorNameLang":"ja"}],"nameIdentifiers":[{"nameIdentifier":"310","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"小林, 智子","creatorNameLang":"ja"},{"creatorName":"コバヤシ, トモコ","creatorNameLang":"ja-Kana"},{"creatorName":"Kobayashi, Tomoko","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"スミダ, サトシ","creatorNameLang":"ja"},{"creatorName":"スミダ, サトシ","creatorNameLang":"ja-Kana"},{"creatorName":"Sumida, Satoshi","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"カキモト, タクミ","creatorNameLang":"ja"},{"creatorName":"カキモト, タクミ","creatorNameLang":"ja-Kana"},{"creatorName":"Kakimoto, Takumi","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"山下, 理子","creatorNameLang":"ja"}],"nameIdentifiers":[{"nameIdentifier":"989","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Cheng, Chunmei","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"常山, 幸一","creatorNameLang":"ja"}],"nameIdentifiers":[{"nameIdentifier":"756","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_access","date":[{"dateType":"Available","dateValue":"2021-10-06"}],"displaytype":"detail","filename":"k3535_abstract_review.pdf","filesize":[{"value":"194 KB"}],"format":"application/pdf","mimetype":"application/pdf","url":{"objectType":"abstract","url":"https://tokushima-u.repo.nii.ac.jp/record/2009261/files/k3535_abstract_review.pdf"},"version_id":"71fe2417-6c8b-4d21-b5ff-9dcc04431b97"},{"accessrole":"open_access","date":[{"dateType":"Available","dateValue":"2021-10-06"}],"displaytype":"detail","filename":"k3535_fulltext.pdf","filesize":[{"value":"707 KB"}],"format":"application/pdf","mimetype":"application/pdf","url":{"objectType":"fulltext","url":"https://tokushima-u.repo.nii.ac.jp/record/2009261/files/k3535_fulltext.pdf"},"version_id":"9466763a-6d2d-4352-a031-1ac90f37b517"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"Mass spectrometry","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Rapid cytological diagnosis","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Probe electrospray ionization mass spectrometry","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Lung cytopathology","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"doctoral thesis","resourceuri":"http://purl.org/coar/resource_type/c_db06"}]},"item_title":"Applying Probe Electrospray Ionization Mass Spectrometry to Cytological Diagnosis : A Preliminary Study by Using Cultured Lung Cancer Cells","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Applying Probe Electrospray Ionization Mass Spectrometry to Cytological Diagnosis : A Preliminary Study by Using Cultured Lung Cancer Cells","subitem_title_language":"en"}]},"item_type_id":"40001","owner":"7","path":["1716268551628"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2021-10-06"},"publish_date":"2021-10-06","publish_status":"0","recid":"2009261","relation_version_is_last":true,"title":["Applying Probe Electrospray Ionization Mass Spectrometry to Cytological Diagnosis : A Preliminary Study by Using Cultured Lung Cancer Cells"],"weko_creator_id":"7","weko_shared_id":-1},"updated":"2024-12-12T01:27:54.400614+00:00"}