{"created":"2024-12-12T01:30:37.014732+00:00","id":2009295,"links":{},"metadata":{"_buckets":{"deposit":"60450f0f-7f03-432c-b015-857f5264d082"},"_deposit":{"created_by":7,"id":"2009295","owners":[7],"pid":{"revision_id":0,"type":"depid","value":"2009295"},"status":"published"},"_oai":{"id":"oai:tokushima-u.repo.nii.ac.jp:02009295","sets":["1713853213384:1713853296295:1716267877313:1716268556148"]},"author_link":["569","572","813","593","1721","203"],"item_10001_alternative_title_1":{"attribute_name":"タイトル別表記","attribute_value_mlt":[{"subitem_alternative_title":"ヒト角化上皮細胞における5-FU誘発性酸化ストレスおよび炎症応答に対するresveratrolの保護効果","subitem_alternative_title_language":"ja"}]},"item_10001_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2021-11-01","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"3","bibliographicPageEnd":"246","bibliographicPageStart":"238","bibliographicVolumeNumber":"69","bibliographic_titles":[{"bibliographic_title":"Journal of Clinical Biochemistry and Nutrition","bibliographic_titleLang":"en"}]}]},"item_10001_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Although 5-fluorouracil (5-FU) is currently used as an anti-cancer chemotherapy, adverse effects such as oral mucositis potentially limit its clinical application. Additionally, the prevention of 5-FU-induced side effects are scarce. Resveratrol is known to decrease oxidative damage and inflammation. In this study, we examined the protective effects of resveratrol on 5-FU-induced oxidative stress and inflammatory responses in normal human keratinocytes (HaCaT cell) as in vitro oral mucositis model. HaCaT cells were exposed to 5-FU and simultaneously treated with resveratrol. The effects of resveratrol on 5-FU-induced cytotoxicity were evaluated using cell viability assay. The production of reactive oxygen species (ROS) was measured using a fluorescence spectrophotometer. The effects of resveratrol on nuclear factor erythroid 2-related factor 2 (Nrf2), silent information regulator transcript-1 (SIRT-1), and nuclear factor kappa B (NF-κB) signaling and inflammatory cytokine expression were examined. Resveratrol suppressed 5-FU-induced overproduction of ROS by upregulating anti-oxidant defense genes through Nrf2 activation and SIRT-1 expression. Concerning inflammatory responses, resveratrol suppressed the 5-FU-induced expression of pro-inflammatory cytokines via NF-κB nuclear translocation. Conversely, N-acetylcysteine reduced ROS levels without affecting the expression of pro-inflammatory cytokines. Resveratrol might be useful for preventing 5-FU-induced adverse effects by activating anti-oxidant and anti-inflammatory responses.","subitem_description_language":"en","subitem_description_type":"Abstract"}]},"item_10001_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Society for Free Radical Research Japan","subitem_publisher_language":"en"}]},"item_10001_rights_15":{"attribute_name":"権利情報","attribute_value_mlt":[{"subitem_rights":"This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivatives License (https://creativecommons.org/licenses/by-nc-nd/4.0/).","subitem_rights_language":"en"}]},"item_10001_source_id_9":{"attribute_name":"収録物ID","attribute_value_mlt":[{"subitem_source_identifier":"09120009","subitem_source_identifier_type":"ISSN"},{"subitem_source_identifier":"18805086","subitem_source_identifier_type":"ISSN"},{"subitem_source_identifier":"AA10710201","subitem_source_identifier_type":"NCID"}]},"item_10001_version_type_20":{"attribute_name":"出版タイプ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_be7fb7dd8ff6fe43","subitem_version_type":"NA"}]},"item_1714461018643":{"attribute_name":"報告番号","attribute_value_mlt":[{"subitem_dissertationnumber":"甲第3541号"}]},"item_1714461102074":{"attribute_name":"学位名","attribute_value_mlt":[{"subitem_degreename":"博士（歯学）","subitem_degreename_language":"ja"}]},"item_1714461118377":{"attribute_name":"学位授与年月日","attribute_value_mlt":[{"subitem_dategranted":"2021-09-09"}]},"item_1714461137393":{"attribute_name":"学位授与機関","attribute_value_mlt":[{"subitem_degreegrantor":[{"subitem_degreegrantor_language":"ja","subitem_degreegrantor_name":"徳島大学"}]}]},"item_1715043197608":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"open access"}]},"item_1718868208704":{"attribute_name":"備考","attribute_value_mlt":[{"subitem_textarea_language":"ja","subitem_textarea_value":"内容要旨・審査要旨・論文本文の公開\n本論文は，著者Shu Chenの学位論文として提出され，学位審査・授与の対象となっている。\n学位授与者所属 : 徳島大学大学院口腔科学教育部（口腔科学専攻）"}]},"item_1718868303842":{"attribute_name":"学位記番号","attribute_value_mlt":[{"subitem_text_language":"ja","subitem_text_value":"甲口第472号"}]},"item_1722929371688":{"attribute_name":"出版社版DOI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_language":"ja","subitem_relation_name_text":"10.3164/jcbn.21-23"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://doi.org/10.3164/jcbn.21-23","subitem_relation_type_select":"DOI"}}]},"item_1723180141928":{"attribute_name":"EID","attribute_value_mlt":[{"subitem_identifier_type":"URI","subitem_identifier_uri":"386015"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"陳, 舒","creatorNameLang":"ja"},{"creatorName":"チン, ジョ","creatorNameLang":"ja-Kana"},{"creatorName":"Chen, Shu","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"玉木, 直文","creatorNameLang":"ja"}],"nameIdentifiers":[{"nameIdentifier":"569","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"工藤, 保誠","creatorNameLang":"ja"}],"nameIdentifiers":[{"nameIdentifier":"572","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"常松, 貴明","creatorNameLang":"ja"}],"nameIdentifiers":[{"nameIdentifier":"813","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"三木, かなめ","creatorNameLang":"ja"}],"nameIdentifiers":[{"nameIdentifier":"593","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"石丸, 直澄","creatorNameLang":"ja"}],"nameIdentifiers":[{"nameIdentifier":"1721","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"伊藤, 博夫","creatorNameLang":"ja"}],"nameIdentifiers":[{"nameIdentifier":"203","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_access","date":[{"dateType":"Available","dateValue":"2021-10-13"}],"displaytype":"detail","filename":"k3541_abstract.pdf","filesize":[{"value":"203 KB"}],"format":"application/pdf","mimetype":"application/pdf","url":{"objectType":"abstract","url":"https://tokushima-u.repo.nii.ac.jp/record/2009295/files/k3541_abstract.pdf"},"version_id":"33ec021a-5ff7-40ad-a68d-c27f1ca88d72"},{"accessrole":"open_access","date":[{"dateType":"Available","dateValue":"2021-10-13"}],"displaytype":"detail","filename":"k3541_review.pdf","filesize":[{"value":"52.6 KB"}],"format":"application/pdf","mimetype":"application/pdf","url":{"objectType":"other","url":"https://tokushima-u.repo.nii.ac.jp/record/2009295/files/k3541_review.pdf"},"version_id":"e40a236a-f9fa-49d0-b2d2-dbd40aa112be"},{"accessrole":"open_access","date":[{"dateType":"Available","dateValue":"2021-11-01"}],"displaytype":"detail","filename":"k3541_fulltext.pdf","filesize":[{"value":"978 KB"}],"format":"application/pdf","mimetype":"application/pdf","url":{"objectType":"fulltext","url":"https://tokushima-u.repo.nii.ac.jp/record/2009295/files/k3541_fulltext.pdf"},"version_id":"0f36d302-8924-47f6-a16d-9104a8725a61"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"oxidative stress","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"inflammation","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"oral mucositis","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"antioxidant","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":" human normal keratinocyte","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"resveratrol","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"doctoral thesis","resourceuri":"http://purl.org/coar/resource_type/c_db06"}]},"item_title":"Protective effects of resveratrol against 5-fluorouracil-induced oxidative stress and inflammatory responses in human keratinocytes","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Protective effects of resveratrol against 5-fluorouracil-induced oxidative stress and inflammatory responses in human keratinocytes","subitem_title_language":"en"}]},"item_type_id":"40001","owner":"7","path":["1716268556148"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2021-10-13"},"publish_date":"2021-10-13","publish_status":"0","recid":"2009295","relation_version_is_last":true,"title":["Protective effects of resveratrol against 5-fluorouracil-induced oxidative stress and inflammatory responses in human keratinocytes"],"weko_creator_id":"7","weko_shared_id":-1},"updated":"2024-12-12T01:30:47.741704+00:00"}