{"created":"2024-12-12T01:30:41.534684+00:00","id":2009296,"links":{},"metadata":{"_buckets":{"deposit":"3b7b821a-80e9-4cde-b6c9-d8869892d995"},"_deposit":{"created_by":7,"id":"2009296","owners":[7],"pid":{"revision_id":0,"type":"depid","value":"2009296"},"status":"published"},"_oai":{"id":"oai:tokushima-u.repo.nii.ac.jp:02009296","sets":["1713853213384:1713853296295:1716267876683:1716268551628"]},"author_link":["954","1548","1616","676","1556","1521"],"item_10001_alternative_title_1":{"attribute_name":"タイトル別表記","attribute_value_mlt":[{"subitem_alternative_title":"ネクロプトーシスは急性膵炎の悪化を防ぐ","subitem_alternative_title_language":"ja"},{"subitem_alternative_title":"Necroptosis and acute pancreatitis","subitem_alternative_title_language":"en"}]},"item_10001_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2021-06-10","bibliographicIssueDateType":"Issued"},"bibliographicPageStart":"601","bibliographicVolumeNumber":"12","bibliographic_titles":[{"bibliographic_title":"Cell Death & Disease","bibliographic_titleLang":"en"}]}]},"item_10001_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"The sensing of various extrinsic stimuli triggers the receptor-interacting protein kinase-3 (RIPK3)-mediated signaling pathway, which leads to mixed-lineage kinase-like (MLKL) phosphorylation followed by necroptosis. Although necroptosis is a form of cell death and is involved in inflammatory conditions, the roles of necroptosis in acute pancreatitis (AP) remain unclear. In the current study, we administered caerulein to Ripk3- or Mlkl-deficient mice (Ripk3-/- or Mlkl-/- mice, respectively) and assessed the roles of necroptosis in AP. We found that Ripk3-/- mice had significantly more severe pancreatic edema and inflammation associated with macrophage and neutrophil infiltration than control mice. Consistently, Mlkl-/- mice were more susceptible to caerulein-induced AP, which occurred in a time- and dose-dependent manner, than control mice. Mlkl-/- mice exhibit weight loss, edematous pancreatitis, necrotizing pancreatitis, and acinar cell dedifferentiation in response to tissue damage. Genetic deletion of Mlkl resulted in downregulation of the antiapoptotic genes Bclxl and Cflar in association with increases in the numbers of apoptotic cells, as detected by TUNEL assay. These findings suggest that RIPK3 and MLKL-mediated necroptosis exerts protective effects in AP and caution against the use of necroptosis inhibitors for AP treatment.","subitem_description_language":"en","subitem_description_type":"Abstract"}]},"item_10001_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Springer Nature","subitem_publisher_language":"en"}]},"item_10001_source_id_9":{"attribute_name":"収録物ID","attribute_value_mlt":[{"subitem_source_identifier":"20414889","subitem_source_identifier_type":"ISSN"}]},"item_10001_version_type_20":{"attribute_name":"出版タイプ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_be7fb7dd8ff6fe43","subitem_version_type":"NA"}]},"item_1714461018643":{"attribute_name":"報告番号","attribute_value_mlt":[{"subitem_dissertationnumber":"甲第3539号"}]},"item_1714461102074":{"attribute_name":"学位名","attribute_value_mlt":[{"subitem_degreename":"博士（医学）","subitem_degreename_language":"ja"}]},"item_1714461118377":{"attribute_name":"学位授与年月日","attribute_value_mlt":[{"subitem_dategranted":"2021-09-09"}]},"item_1714461137393":{"attribute_name":"学位授与機関","attribute_value_mlt":[{"subitem_degreegrantor":[{"subitem_degreegrantor_language":"ja","subitem_degreegrantor_name":"徳島大学"}]}]},"item_1715043197608":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"open access"}]},"item_1718868208704":{"attribute_name":"備考","attribute_value_mlt":[{"subitem_textarea_language":"ja","subitem_textarea_value":"内容要旨・審査要旨・論文本文の公開\n本論文は，著者Michittra Boonchanの学位論文として提出され，学位審査・授与の対象となっている。\n学位授与者所属 : 徳島大学大学院医科学教育部（医学専攻）"}]},"item_1718868303842":{"attribute_name":"学位記番号","attribute_value_mlt":[{"subitem_text_language":"ja","subitem_text_value":"甲医第1506号"}]},"item_1722929371688":{"attribute_name":"出版社版DOI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_language":"ja","subitem_relation_name_text":"10.1038/s41419-021-03847-w"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://doi.org/10.1038/s41419-021-03847-w","subitem_relation_type_select":"DOI"}}]},"item_1723180141928":{"attribute_name":"EID","attribute_value_mlt":[{"subitem_identifier_type":"URI","subitem_identifier_uri":"376274"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"ブンチャン, ミチトラ","creatorNameLang":"ja"},{"creatorName":"ブンチャン, ミチトラ","creatorNameLang":"ja-Kana"},{"creatorName":"Boonchan, Michittra","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"有持, 秀喜","creatorNameLang":"ja"}],"nameIdentifiers":[{"nameIdentifier":"1616","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"大塚, 邦紘","creatorNameLang":"ja"}],"nameIdentifiers":[{"nameIdentifier":"954","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"小林, 智子","creatorNameLang":"ja"},{"creatorName":"コバヤシ, トモコ","creatorNameLang":"ja-Kana"},{"creatorName":"Kobayashi, Tomoko","creatorNameLang":"en"}]},{"creatorAffiliations":[{"affiliationNameIdentifiers":[{"affiliationNameIdentifier":"","affiliationNameIdentifierScheme":"ISNI","affiliationNameIdentifierURI":"http://www.isni.org/isni/"}],"affiliationNames":[{"affiliationName":"","affiliationNameLang":"ja"}]}],"creatorNames":[{"creatorName":"上原, 久典","creatorNameLang":"ja"},{"creatorName":"ウエハラ, ヒサノリ","creatorNameLang":"ja-Kana"},{"creatorName":"Uehara, Hisanori","creatorNameLang":"en"}],"familyNames":[{"familyName":"上原","familyNameLang":"ja"},{"familyName":"ウエハラ","familyNameLang":"ja-Kana"},{"familyName":"Uehara","familyNameLang":"en"}],"givenNames":[{"givenName":"久典","givenNameLang":"ja"},{"givenName":"ヒサノリ","givenNameLang":"ja-Kana"},{"givenName":"Hisanori","givenNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"1548","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"60072/profile-ja.html","nameIdentifierScheme":"徳島大学 教育研究者総覧","nameIdentifierURI":"http://pub2.db.tokushima-u.ac.jp/ERD/person/60072/profile-ja.html"},{"nameIdentifier":"30263809","nameIdentifierScheme":"e-Rad","nameIdentifierURI":"https://nrid.nii.ac.jp/ja/search/?qm=30263809"}]},{"creatorNames":[{"creatorName":"Jaroonwitchawan, Thiranut","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"佐々木, 由紀","creatorNameLang":"ja"}],"nameIdentifiers":[{"nameIdentifier":"676","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"九十九, 伸一","creatorNameLang":"ja"}],"nameIdentifiers":[{"nameIdentifier":"1556","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"安友, 康二","creatorNameLang":"ja"}],"nameIdentifiers":[{"nameIdentifier":"1521","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_access","date":[{"dateType":"Available","dateValue":"2021-10-13"}],"displaytype":"detail","filename":"k3539_abstract_review.pdf","filesize":[{"value":"197 KB"}],"format":"application/pdf","mimetype":"application/pdf","url":{"objectType":"abstract","url":"https://tokushima-u.repo.nii.ac.jp/record/2009296/files/k3539_abstract_review.pdf"},"version_id":"95b9a2c0-ef72-4cae-906b-68a05a82f81f"},{"accessrole":"open_access","date":[{"dateType":"Available","dateValue":"2021-10-14"}],"displaytype":"detail","filename":"k3539_fulltext.pdf","filesize":[{"value":"4.51 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