{"created":"2024-12-12T01:30:54.545467+00:00","id":2009298,"links":{},"metadata":{"_buckets":{"deposit":"d1449cac-48dc-4f7e-ab32-5655664e9d29"},"_deposit":{"created_by":7,"id":"2009298","owners":[7],"pid":{"revision_id":0,"type":"depid","value":"2009298"},"status":"published"},"_oai":{"id":"oai:tokushima-u.repo.nii.ac.jp:02009298","sets":["1713853213384:1713853296295:1716267877313:1716268556148"]},"author_link":["982","871","1434","1689","859","851","812","589"],"item_10001_alternative_title_1":{"attribute_name":"タイトル別表記","attribute_value_mlt":[{"subitem_alternative_title":"片側末梢投与されたA型ボツリヌス毒素は動物モデルにおいて両側三叉神経節に局在する","subitem_alternative_title_language":"ja"}]},"item_10001_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2021-10-05","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"10","bibliographicPageStart":"704","bibliographicVolumeNumber":"13","bibliographic_titles":[{"bibliographic_title":"Toxins","bibliographic_titleLang":"en"}]}]},"item_10001_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Peripheral nerve injury leads to sensory ganglion hyperexcitation, which increases neurotransmitter release and neuropathic pain. Botulinum toxin type A (BoNT/A) regulates pain transmission by reducing neurotransmitter release, thereby attenuating neuropathic pain. Despite multiple studies on the use of BoNT/A for managing neuropathic pain in the orofacial region, its exact mechanism of transport remains unclear. In this study, we investigated the effects of BoNT/A in managing neuropathic pain in two different animal models and its transport mechanism in the trigeminal nerve. Intraperitoneal administration of cisplatin induced bilateral neuropathic pain in the orofacial region, reducing the head withdrawal threshold to mechanical stimulation. Unilateral infraorbital nerve constriction (IONC) also reduced the ipsilateral head withdrawal threshold to mechanical stimulation. Unilateral peripheral administration of BoNT/A to the rat whisker pad attenuated cisplatin-induced pain behavior bilaterally. Furthermore, contralateral peripheral administration of BoNT/A attenuated neuropathy-induced behavior caused by IONC. We also noted the presence of BoNT/A in the blood using the mouse bioassay. In addition, the Alexa Fluor-488-labeled C-terminal half of the heavy chain of BoNT/A (BoNT/A-Hc) was localized in the neurons of the bilateral trigeminal ganglia following its unilateral administration. These findings suggest that axonal and hematogenous transport are involved in the therapeutic effects of peripherally administered BoNT/A in the orofacial region.","subitem_description_language":"en","subitem_description_type":"Abstract"}]},"item_10001_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"MDPI","subitem_publisher_language":"en"}]},"item_10001_rights_15":{"attribute_name":"権利情報","attribute_value_mlt":[{"subitem_rights":"This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).","subitem_rights_language":"en"}]},"item_10001_source_id_9":{"attribute_name":"収録物ID","attribute_value_mlt":[{"subitem_source_identifier":"20726651","subitem_source_identifier_type":"ISSN"}]},"item_10001_version_type_20":{"attribute_name":"出版タイプ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_be7fb7dd8ff6fe43","subitem_version_type":"NA"}]},"item_1714461018643":{"attribute_name":"報告番号","attribute_value_mlt":[{"subitem_dissertationnumber":"甲第3609号"}]},"item_1714461102074":{"attribute_name":"学位名","attribute_value_mlt":[{"subitem_degreename":"博士（歯学）","subitem_degreename_language":"ja"}]},"item_1714461118377":{"attribute_name":"学位授与年月日","attribute_value_mlt":[{"subitem_dategranted":"2022-03-23"}]},"item_1714461137393":{"attribute_name":"学位授与機関","attribute_value_mlt":[{"subitem_degreegrantor":[{"subitem_degreegrantor_language":"ja","subitem_degreegrantor_name":"徳島大学"}]}]},"item_1715043197608":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"open access"}]},"item_1718868208704":{"attribute_name":"備考","attribute_value_mlt":[{"subitem_textarea_language":"ja","subitem_textarea_value":"内容要旨・審査要旨・論文本文の公開\n本論文は，著者Arief Waskithoの学位論文として提出され，学位審査・授与の対象となっている。\n学位授与者所属 : 徳島大学大学院口腔科学教育部（口腔科学専攻）"}]},"item_1718868303842":{"attribute_name":"学位記番号","attribute_value_mlt":[{"subitem_text_language":"ja","subitem_text_value":"甲口第477号"}]},"item_1722929371688":{"attribute_name":"出版社版DOI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_language":"ja","subitem_relation_name_text":"10.3390/toxins13100704"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://doi.org/10.3390/toxins13100704","subitem_relation_type_select":"DOI"}}]},"item_1723180141928":{"attribute_name":"EID","attribute_value_mlt":[{"subitem_identifier_type":"URI","subitem_identifier_uri":"382624"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"ワスキソ, アリーフ","creatorNameLang":"ja"},{"creatorName":"ワスキソ, アリーフ","creatorNameLang":"ja-Kana"},{"creatorName":"Waskitho, Arief","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"ヤマモト, ユミコ","creatorNameLang":"ja"},{"creatorName":"ヤマモト, ユミコ","creatorNameLang":"ja-Kana"},{"creatorName":"Yamamoto, Yumiko","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Raman, Swarnalakshmi","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"加納, 史也","creatorNameLang":"ja"}],"nameIdentifiers":[{"nameIdentifier":"982","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Yan, Huijiao","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Raju, Resmi","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Afroz, Shaista","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"守田, 剛","creatorNameLang":"ja"}],"nameIdentifiers":[{"nameIdentifier":"871","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"生田目, 大介","creatorNameLang":"ja"}],"nameIdentifiers":[{"nameIdentifier":"1434","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"大倉, 一夫","creatorNameLang":"ja"}],"nameIdentifiers":[{"nameIdentifier":"1689","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"大島, 正充","creatorNameLang":"ja"}],"nameIdentifiers":[{"nameIdentifier":"859","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"山本, 朗仁","creatorNameLang":"ja"}],"nameIdentifiers":[{"nameIdentifier":"851","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"馬場, 麻人","creatorNameLang":"ja"}],"nameIdentifiers":[{"nameIdentifier":"812","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"松香, 芳三","creatorNameLang":"ja"}],"nameIdentifiers":[{"nameIdentifier":"589","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_access","date":[{"dateType":"Available","dateValue":"2022-04-26"}],"displaytype":"detail","filename":"k3609_abstract.pdf","filesize":[{"value":"114 KB"}],"format":"application/pdf","mimetype":"application/pdf","url":{"objectType":"abstract","url":"https://tokushima-u.repo.nii.ac.jp/record/2009298/files/k3609_abstract.pdf"},"version_id":"19f57239-daa9-4e65-af3b-64889f08f1fd"},{"accessrole":"open_access","date":[{"dateType":"Available","dateValue":"2022-04-26"}],"displaytype":"detail","filename":"k3609_review.pdf","filesize":[{"value":"61 KB"}],"format":"application/pdf","mimetype":"application/pdf","url":{"objectType":"other","url":"https://tokushima-u.repo.nii.ac.jp/record/2009298/files/k3609_review.pdf"},"version_id":"25178ad6-d47a-4cb1-ba2f-2208c906a8b0"},{"accessrole":"open_access","date":[{"dateType":"Available","dateValue":"2022-04-26"}],"displaytype":"detail","filename":"k3609_fulltext.pdf","filesize":[{"value":"2 MB"}],"format":"application/pdf","mimetype":"application/pdf","url":{"objectType":"fulltext","url":"https://tokushima-u.repo.nii.ac.jp/record/2009298/files/k3609_fulltext.pdf"},"version_id":"19e25c9f-3e79-4fb3-b65e-62361a38673f"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"Botulinum toxin","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"trigeminal ganglion","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"neuropathic pain","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"doctoral thesis","resourceuri":"http://purl.org/coar/resource_type/c_db06"}]},"item_title":"Peripherally Administered Botulinum Toxin Type a Localizes Bilaterally in Trigeminal Ganglia of Animal Model","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Peripherally Administered Botulinum Toxin Type a Localizes Bilaterally in Trigeminal Ganglia of Animal Model","subitem_title_language":"en"}]},"item_type_id":"40001","owner":"7","path":["1716268556148"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2021-10-14"},"publish_date":"2021-10-14","publish_status":"0","recid":"2009298","relation_version_is_last":true,"title":["Peripherally Administered Botulinum Toxin Type a Localizes Bilaterally in Trigeminal Ganglia of Animal Model"],"weko_creator_id":"7","weko_shared_id":-1},"updated":"2024-12-12T01:31:06.300839+00:00"}