{"created":"2024-12-12T01:34:42.650278+00:00","id":2009351,"links":{},"metadata":{"_buckets":{"deposit":"6f76ac84-876d-46e6-89d0-9935e76c3250"},"_deposit":{"created_by":7,"id":"2009351","owners":[7],"pid":{"revision_id":0,"type":"depid","value":"2009351"},"status":"published"},"_oai":{"id":"oai:tokushima-u.repo.nii.ac.jp:02009351","sets":["1713853213384:1713853295607"]},"author_link":["183","231","197","564","340","309"],"control_number":"2009351","item_10001_alternative_title_1":{"attribute_name":"タイトル別表記","attribute_value_mlt":[{"subitem_alternative_title":"The Role of S1P2 in Atherogenesis","subitem_alternative_title_language":"en"}]},"item_10001_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2021-06-01","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"6","bibliographicPageEnd":"642","bibliographicPageStart":"630","bibliographicVolumeNumber":"28","bibliographic_titles":[{"bibliographic_title":"Journal of Atherosclerosis and Thrombosis","bibliographic_titleLang":"en"}]}]},"item_10001_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Aim: The bioactive lipid, sphingosine-1-phosphate (S1P), has various roles in the physiology and pathophysiology of many diseases. There are five S1P receptors; however, the role of each S1P receptor in atherogenesis is still obscure. Here we investigated the contribution of S1P receptor 2 (S1P2) to atherogenesis by using a specific S1P2 antagonist, ONO-5430514, in apolipoprotein E-deficient (Apoe−/− ) mice.\nMethods: Apoe−/− mice fed with a western-type diet (WTD) received ONO-5430514 (30 mg/kg/day) or vehicle. To examine the effect on atherogenesis, Sudan IV staining, histological analysis, qPCR, and vascular reactivity assay was performed. Human umbilical vein endothelial cells (HUVEC) were used for in vitro experiments.\nResults: WTD-fed Apoe−/− mice had significantly higher S1P2 expression in the aorta compared with wild-type mice. S1P2 antagonist treatment for 20 weeks reduced atherosclerotic lesion development (p＜0.05). S1P2 antagonist treatment for 8 weeks ameliorated endothelial dysfunction (p＜0.05) accompanied with significant reduction of lipid deposition, macrophage accumulation, and inflammatory molecule expression in the aorta compared with vehicle. S1P2 antagonist attenuated the phosphorylation of JNK in the abdominal aorta compared with vehicle (p＜0.05). In HUVEC, S1P promoted inflammatory molecule expression such as MCP-1 and VCAM-1 (p＜0.001), which was attenuated by S1P2 antagonist or a JNK inhibitor (p＜0.01). S1P2 antagonist also inhibited S1P-induced JNK phosphorylation in HUVEC (p＜0.05).\nConclusions: Our results suggested that an S1P2 antagonist attenuates endothelial dysfunction and prevents atherogenesis. S1P2, which promotes inflammatory activation of endothelial cells, might be a therapeutic target for atherosclerosis.","subitem_description_language":"en","subitem_description_type":"Abstract"}]},"item_10001_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Japan Atherosclerosis Society","subitem_publisher_language":"en"}]},"item_10001_rights_15":{"attribute_name":"権利情報","attribute_value_mlt":[{"subitem_rights":"This article is distributed under the terms of the latest version of CC BY-NC-SA defined by the Creative Commons Attribution License.","subitem_rights_language":"en"}]},"item_10001_source_id_9":{"attribute_name":"収録物ID","attribute_value_mlt":[{"subitem_source_identifier":"18803873","subitem_source_identifier_type":"ISSN"},{"subitem_source_identifier":"13403478","subitem_source_identifier_type":"ISSN"}]},"item_10001_version_type_20":{"attribute_name":"出版タイプ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_1715043197608":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"open access"}]},"item_1722929371688":{"attribute_name":"出版社版DOI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_language":"ja","subitem_relation_name_text":"10.5551/jat.54916"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://doi.org/10.5551/jat.54916","subitem_relation_type_select":"DOI"}}]},"item_1723180141928":{"attribute_name":"EID","attribute_value_mlt":[{"subitem_identifier_type":"URI","subitem_identifier_uri":"371088"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Ganbaatar, Byambasuren","creatorNameLang":"en"}]},{"creatorAffiliations":[{"affiliationNameIdentifiers":[{"affiliationNameIdentifier":"","affiliationNameIdentifierScheme":"ISNI","affiliationNameIdentifierURI":"http://www.isni.org/isni/"}],"affiliationNames":[{"affiliationName":"","affiliationNameLang":"ja"}]}],"creatorNames":[{"creatorName":"福田, 大受","creatorNameLang":"ja"},{"creatorName":"フクダ, ダイジュ","creatorNameLang":"ja-Kana"},{"creatorName":"Fukuda, Daiju","creatorNameLang":"en"}],"familyNames":[{"familyName":"福田","familyNameLang":"ja"},{"familyName":"フクダ","familyNameLang":"ja-Kana"},{"familyName":"Fukuda","familyNameLang":"en"}],"givenNames":[{"givenName":"大受","givenNameLang":"ja"},{"givenName":"ダイジュ","givenNameLang":"ja-Kana"},{"givenName":"Daiju","givenNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"564","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"40637568","nameIdentifierScheme":"e-Rad","nameIdentifierURI":"https://nrid.nii.ac.jp/ja/search/?qm=40637568"}]},{"creatorNames":[{"creatorName":"シノハラ, マサカズ","creatorNameLang":"ja"},{"creatorName":"シノハラ, マサカズ","creatorNameLang":"ja-Kana"},{"creatorName":"Shinohara, Masakazu","creatorNameLang":"en"}]},{"creatorAffiliations":[{"affiliationNameIdentifiers":[{"affiliationNameIdentifier":"","affiliationNameIdentifierScheme":"ISNI","affiliationNameIdentifierURI":"http://www.isni.org/isni/"}],"affiliationNames":[{"affiliationName":"","affiliationNameLang":"ja"}]}],"creatorNames":[{"creatorName":"八木, 秀介","creatorNameLang":"ja"},{"creatorName":"ヤギ, シュウスケ","creatorNameLang":"ja-Kana"},{"creatorName":"Yagi, Shusuke","creatorNameLang":"en"}],"familyNames":[{"familyName":"八木","familyNameLang":"ja"},{"familyName":"ヤギ","familyNameLang":"ja-Kana"},{"familyName":"Yagi","familyNameLang":"en"}],"givenNames":[{"givenName":"秀介","givenNameLang":"ja"},{"givenName":"シュウスケ","givenNameLang":"ja-Kana"},{"givenName":"Shusuke","givenNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"340","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"178255/profile-ja.html","nameIdentifierScheme":"徳島大学 教育研究者総覧","nameIdentifierURI":"http://pub2.db.tokushima-u.ac.jp/ERD/person/178255/profile-ja.html"},{"nameIdentifier":"00507650","nameIdentifierScheme":"e-Rad","nameIdentifierURI":"https://nrid.nii.ac.jp/ja/search/?qm=00507650"}]},{"creatorAffiliations":[{"affiliationNameIdentifiers":[{"affiliationNameIdentifier":"","affiliationNameIdentifierScheme":"ISNI","affiliationNameIdentifierURI":"http://www.isni.org/isni/"}],"affiliationNames":[{"affiliationName":"","affiliationNameLang":"ja"}]}],"creatorNames":[{"creatorName":"楠瀬, 賢也","creatorNameLang":"ja"},{"creatorName":"クスノセ, ケンヤ","creatorNameLang":"ja-Kana"},{"creatorName":"Kusunose, Kenya","creatorNameLang":"en"}],"familyNames":[{"familyName":"楠瀬","familyNameLang":"ja"},{"familyName":"クスノセ","familyNameLang":"ja-Kana"},{"familyName":"Kusunose","familyNameLang":"en"}],"givenNames":[{"givenName":"賢也","givenNameLang":"ja"},{"givenName":"ケンヤ","givenNameLang":"ja-Kana"},{"givenName":"Kenya","givenNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"231","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"145741/profile-ja.html","nameIdentifierScheme":"徳島大学 教育研究者総覧","nameIdentifierURI":"http://pub2.db.tokushima-u.ac.jp/ERD/person/145741/profile-ja.html"},{"nameIdentifier":"70507649","nameIdentifierScheme":"e-Rad","nameIdentifierURI":"https://nrid.nii.ac.jp/ja/search/?qm=70507649"}]},{"creatorAffiliations":[{"affiliationNameIdentifiers":[{"affiliationNameIdentifier":"","affiliationNameIdentifierScheme":"ISNI","affiliationNameIdentifierURI":"http://www.isni.org/isni/"}],"affiliationNames":[{"affiliationName":"","affiliationNameLang":"ja"}]}],"creatorNames":[{"creatorName":"山田, 博胤","creatorNameLang":"ja"},{"creatorName":"ヤマダ, ヒロツグ","creatorNameLang":"ja-Kana"},{"creatorName":"Yamada, Hirotsugu","creatorNameLang":"en"}],"familyNames":[{"familyName":"山田","familyNameLang":"ja"},{"familyName":"ヤマダ","familyNameLang":"ja-Kana"},{"familyName":"Yamada","familyNameLang":"en"}],"givenNames":[{"givenName":"博胤","givenNameLang":"ja"},{"givenName":"ヒロツグ","givenNameLang":"ja-Kana"},{"givenName":"Hirotsugu","givenNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"197","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"123698/profile-ja.html","nameIdentifierScheme":"徳島大学 教育研究者総覧","nameIdentifierURI":"http://pub2.db.tokushima-u.ac.jp/ERD/person/123698/profile-ja.html"},{"nameIdentifier":"40380084","nameIdentifierScheme":"e-Rad","nameIdentifierURI":"https://nrid.nii.ac.jp/ja/search/?qm=40380084"}]},{"creatorAffiliations":[{"affiliationNameIdentifiers":[{"affiliationNameIdentifier":"","affiliationNameIdentifierScheme":"ISNI","affiliationNameIdentifierURI":"http://www.isni.org/isni/"}],"affiliationNames":[{"affiliationName":"","affiliationNameLang":"ja"}]}],"creatorNames":[{"creatorName":"添木, 武","creatorNameLang":"ja"},{"creatorName":"ソエキ, タケシ","creatorNameLang":"ja-Kana"},{"creatorName":"Soeki, Takeshi","creatorNameLang":"en"}],"familyNames":[{"familyName":"添木","familyNameLang":"ja"},{"familyName":"ソエキ","familyNameLang":"ja-Kana"},{"familyName":"Soeki","familyNameLang":"en"}],"givenNames":[{"givenName":"武","givenNameLang":"ja"},{"givenName":"タケシ","givenNameLang":"ja-Kana"},{"givenName":"Takeshi","givenNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"183","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"121162/profile-ja.html","nameIdentifierScheme":"徳島大学 教育研究者総覧","nameIdentifierURI":"http://pub2.db.tokushima-u.ac.jp/ERD/person/121162/profile-ja.html"},{"nameIdentifier":"60393211","nameIdentifierScheme":"e-Rad","nameIdentifierURI":"https://nrid.nii.ac.jp/ja/search/?qm=60393211"}]},{"creatorNames":[{"creatorName":"ヒラタ, ケンイチ","creatorNameLang":"ja"},{"creatorName":"ヒラタ, ケンイチ","creatorNameLang":"ja-Kana"},{"creatorName":"Hirata, Ken-ichi","creatorNameLang":"en"}]},{"creatorAffiliations":[{"affiliationNameIdentifiers":[{"affiliationNameIdentifier":"","affiliationNameIdentifierScheme":"ISNI","affiliationNameIdentifierURI":"http://www.isni.org/isni/"}],"affiliationNames":[{"affiliationName":"","affiliationNameLang":"ja"}]}],"creatorNames":[{"creatorName":"佐田, 政隆","creatorNameLang":"ja"},{"creatorName":"サタ, マサタカ","creatorNameLang":"ja-Kana"},{"creatorName":"Sata, Masataka","creatorNameLang":"en"}],"familyNames":[{"familyName":"佐田","familyNameLang":"ja"},{"familyName":"サタ","familyNameLang":"ja-Kana"},{"familyName":"Sata","familyNameLang":"en"}],"givenNames":[{"givenName":"政隆","givenNameLang":"ja"},{"givenName":"マサタカ","givenNameLang":"ja-Kana"},{"givenName":"Masataka","givenNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"309","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"173932/profile-ja.html","nameIdentifierScheme":"徳島大学 教育研究者総覧","nameIdentifierURI":"http://pub2.db.tokushima-u.ac.jp/ERD/person/173932/profile-ja.html"},{"nameIdentifier":"80345214","nameIdentifierScheme":"e-Rad","nameIdentifierURI":"https://nrid.nii.ac.jp/ja/search/?qm=80345214"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_access","date":[{"dateType":"Available","dateValue":"2021-11-12"}],"displaytype":"detail","filename":"jat_28_6_630.pdf","filesize":[{"value":"688 KB"}],"format":"application/pdf","licensetype":"license_4","mimetype":"application/pdf","url":{"objectType":"fulltext","url":"https://tokushima-u.repo.nii.ac.jp/record/2009351/files/jat_28_6_630.pdf"},"version_id":"f9a42cda-d76d-4f18-aac0-0000a1a4d447"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"Atherosclerosis","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Inflammation","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Endothelial function","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"S1P2 receptor","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"S1P","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Inhibition of S1P Receptor 2 Attenuates Endothelial Dysfunction and Inhibits Atherogenesis in Apolipoprotein E-Deficient Mice","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Inhibition of S1P Receptor 2 Attenuates Endothelial Dysfunction and Inhibits Atherogenesis in Apolipoprotein E-Deficient Mice","subitem_title_language":"en"}]},"item_type_id":"40001","owner":"7","path":["1713853295607"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2021-11-12"},"publish_date":"2021-11-12","publish_status":"0","recid":"2009351","relation_version_is_last":true,"title":["Inhibition of S1P Receptor 2 Attenuates Endothelial Dysfunction and Inhibits Atherogenesis in Apolipoprotein E-Deficient Mice"],"weko_creator_id":"7","weko_shared_id":-1},"updated":"2025-02-10T06:42:03.209867+00:00"}