{"created":"2024-12-12T01:36:07.216866+00:00","id":2009368,"links":{},"metadata":{"_buckets":{"deposit":"2644e390-5e1d-4bcc-aa38-459ac6c21cff"},"_deposit":{"created_by":7,"id":"2009368","owners":[7],"pid":{"revision_id":0,"type":"depid","value":"2009368"},"status":"published"},"_oai":{"id":"oai:tokushima-u.repo.nii.ac.jp:02009368","sets":["1713853213384:1713853295607"]},"author_link":["828"],"control_number":"2009368","item_10001_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2020-12-30","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"1","bibliographicPageStart":"22","bibliographicVolumeNumber":"14","bibliographic_titles":[{"bibliographic_title":"Pharmaceuticals","bibliographic_titleLang":"en"}]}]},"item_10001_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"In a previous study, we reported on the development of a synthetic polymer conjugate of pirarubicin (THP) that was formed via an acid-labile hydrazone bond between the polymer and the THP. However, the synthetic polymer itself was non-biodegradable, which could lead to unexpected adverse effects. Human serum albumin (HSA), which has a high biocompatibility and good biodegradability, is also a potent carrier for delivering antitumor drugs. The objective of this study was to develop pH-sensitive HSA conjugates of THP (HSA-THP), and investigate the release of THP and the cytotoxicity under acidic conditions in vitro for further clinical development. HSA-THP was synthesized by conjugating maleimide hydrazone derivatives of THP with poly-thiolated HSA using 2-iminothiolane, via a thiol-maleimide coupling reaction. We synthesized two types of HSA-THP that contained different amounts of THP (HSA-THP2 and HSA-THP4). Free THP was released from both of the HSA conjugates more rapidly at an acidic pH, and the rates of release for HSA-THP2 and HSA-THP4 were similar. Moreover, both HSA-THPs exhibited a higher cytotoxicity at acidic pH than at neutral pH, which is consistent with the effective liberation of free THP under acidic conditions. These findings suggest that these types of HSA-THPs are promising candidates for further development.","subitem_description_language":"en","subitem_description_type":"Abstract"}]},"item_10001_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"MDPI","subitem_publisher_language":"en"}]},"item_10001_rights_15":{"attribute_name":"権利情報","attribute_value_mlt":[{"subitem_rights":"This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).","subitem_rights_language":"en"}]},"item_10001_source_id_9":{"attribute_name":"収録物ID","attribute_value_mlt":[{"subitem_source_identifier":"14248247","subitem_source_identifier_type":"ISSN"}]},"item_10001_version_type_20":{"attribute_name":"出版タイプ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_1715043197608":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"open access"}]},"item_1722929371688":{"attribute_name":"出版社版DOI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_language":"ja","subitem_relation_name_text":"10.3390/ph14010022"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://doi.org/10.3390/ph14010022","subitem_relation_type_select":"DOI"}}]},"item_1723180141928":{"attribute_name":"EID","attribute_value_mlt":[{"subitem_identifier_type":"URI","subitem_identifier_uri":"374278"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"ツキガワ, ケンジ","creatorNameLang":"ja"},{"creatorName":"ツキガワ, ケンジ","creatorNameLang":"ja-Kana"},{"creatorName":"Tsukigawa, Kenji","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"イモト, シュウヘイ","creatorNameLang":"ja"},{"creatorName":"イモト, シュウヘイ","creatorNameLang":"ja-Kana"},{"creatorName":"Imoto, Shuhei","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"ヤマサキ, ケイシ","creatorNameLang":"ja"},{"creatorName":"ヤマサキ, ケイシ","creatorNameLang":"ja-Kana"},{"creatorName":"Yamasaki, Keishi","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"ニシ, コウジ","creatorNameLang":"ja"},{"creatorName":"ニシ, コウジ","creatorNameLang":"ja-Kana"},{"creatorName":"Nishi, Koji","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"ツツミ, トシヒコ","creatorNameLang":"ja"},{"creatorName":"ツツミ, トシヒコ","creatorNameLang":"ja-Kana"},{"creatorName":"Tsutsumi, Toshihiko","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"ヨコヤマ, ショウコ","creatorNameLang":"ja"},{"creatorName":"ヨコヤマ, ショウコ","creatorNameLang":"ja-Kana"},{"creatorName":"Yokoyama, Shoko","creatorNameLang":"en"}]},{"creatorAffiliations":[{"affiliationNameIdentifiers":[{"affiliationNameIdentifier":"","affiliationNameIdentifierScheme":"ISNI","affiliationNameIdentifierURI":"http://www.isni.org/isni/"}],"affiliationNames":[{"affiliationName":"","affiliationNameLang":"ja"}]}],"creatorNames":[{"creatorName":"異島, 優","creatorNameLang":"ja"},{"creatorName":"イシマ, ユウ","creatorNameLang":"ja-Kana"},{"creatorName":"Ishima, Yu","creatorNameLang":"en"}],"familyNames":[{"familyName":"異島","familyNameLang":"ja"},{"familyName":"イシマ","familyNameLang":"ja-Kana"},{"familyName":"Ishima","familyNameLang":"en"}],"givenNames":[{"givenName":"優","givenNameLang":"ja"},{"givenName":"ユウ","givenNameLang":"ja-Kana"},{"givenName":"Yu","givenNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"828","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"310655/profile-ja.html","nameIdentifierScheme":"徳島大学 教育研究者総覧","nameIdentifierURI":"http://pub2.db.tokushima-u.ac.jp/ERD/person/310655/profile-ja.html"}]},{"creatorNames":[{"creatorName":"オタギリ, マサキ","creatorNameLang":"ja"},{"creatorName":"オタギリ, マサキ","creatorNameLang":"ja-Kana"},{"creatorName":"Otagiri, Masaki","creatorNameLang":"en"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_access","date":[{"dateType":"Available","dateValue":"2021-12-02"}],"displaytype":"detail","filename":"ph_14_1_22.pdf","filesize":[{"value":"1.83 MB"}],"format":"application/pdf","licensetype":"license_0","mimetype":"application/pdf","url":{"objectType":"fulltext","url":"https://tokushima-u.repo.nii.ac.jp/record/2009368/files/ph_14_1_22.pdf"},"version_id":"d545ded5-f54f-42a0-af3a-c9cfb0ec4671"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"pirarubicin (THP)","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"human serum albumin (HSA)","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"HSA-drug conjugates","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"pH-sensitive","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"drug release","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"cytotoxicity","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Synthesis and In Vitro Assessment of pH-Sensitive Human Serum Albumin Conjugates of Pirarubicin","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Synthesis and In Vitro Assessment of pH-Sensitive Human Serum Albumin Conjugates of Pirarubicin","subitem_title_language":"en"}]},"item_type_id":"40001","owner":"7","path":["1713853295607"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2021-12-02"},"publish_date":"2021-12-02","publish_status":"0","recid":"2009368","relation_version_is_last":true,"title":["Synthesis and In Vitro Assessment of pH-Sensitive Human Serum Albumin Conjugates of Pirarubicin"],"weko_creator_id":"7","weko_shared_id":-1},"updated":"2025-01-29T11:53:44.676734+00:00"}