{"created":"2024-12-12T01:36:46.586677+00:00","id":2009376,"links":{},"metadata":{"_buckets":{"deposit":"5428af59-2ef0-47f3-bc91-b01246cbe8c2"},"_deposit":{"created_by":7,"id":"2009376","owners":[7],"pid":{"revision_id":0,"type":"depid","value":"2009376"},"status":"published"},"_oai":{"id":"oai:tokushima-u.repo.nii.ac.jp:02009376","sets":["1713853213384:1713853295607"]},"author_link":["1542","209"],"control_number":"2009376","item_10001_alternative_title_1":{"attribute_name":"タイトル別表記","attribute_value_mlt":[{"subitem_alternative_title":"Analysis of DOC and Ram for NSCLC","subitem_alternative_title_language":"en"}]},"item_10001_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2019-08","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"4","bibliographicPageEnd":"460","bibliographicPageStart":"450","bibliographicVolumeNumber":"8","bibliographic_titles":[{"bibliographic_title":"Translational Lung Cancer Research","bibliographic_titleLang":"en"}]}]},"item_10001_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Background: Current clinical trials demonstrated that combination regimens comprising chemotherapy and immunotherapy lead to better patient outcomes compared to chemotherapy alone as the first line of treatment for non-small cell lung cancer (NSCLC). In addition, the combination therapy of docetaxel (Doc) and ramucirumab (Ram) was considered one of the standard treatments for advanced or relapsed NSCLC patients. However, little is known about the therapeutic responders of this combination therapy among previously treated NSCLC patients. In the present study, we aimed to identify predictive factors for therapeutic response, including programmed death-ligand 1 (PD-L1) expression in tumors, for Doc treatment in combination with Ram.\nMethods: We retrospectively analyzed a total of 135 advanced or relapsed NSCLC patients who were refractory to platinum-based chemotherapy at eleven institutions in Japan between July 2016 and November 2018.\nResults: Our observations showed that PD-L1 expression in tumors is not associated with the efficacy of combined therapy of Doc and Ram in previously treated NSCLC patients. Analysis of the patient clinical profiles indicated that prior treatment with immune checkpoint inhibitors (ICIs) is a reliable predictor for the good progression-free survival (PFS) to this combination therapy (P=0.041).\nConclusions: Our retrospective study indicated that combination regimens comprising chemotherapy and ICIs followed by Doc and Ram could be an optimal therapeutic option for NSCLC patients regardless of the PD-L1 status of tumors. Further investigations are required to strengthen clinical evidence demonstrating the effectiveness of the combination therapy of Doc plus Ram in previously treated NSCLC patients.","subitem_description_language":"en","subitem_description_type":"Abstract"}]},"item_10001_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"AME Publishing Company","subitem_publisher_language":"en"}]},"item_10001_rights_15":{"attribute_name":"権利情報","attribute_value_mlt":[{"subitem_rights":"This is an open access article under the CC BY-NC-ND license.","subitem_rights_language":"en"}]},"item_10001_source_id_9":{"attribute_name":"収録物ID","attribute_value_mlt":[{"subitem_source_identifier":"22186751","subitem_source_identifier_type":"ISSN"},{"subitem_source_identifier":"22264477","subitem_source_identifier_type":"ISSN"}]},"item_10001_version_type_20":{"attribute_name":"出版タイプ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_1715043197608":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"open access"}]},"item_1722929371688":{"attribute_name":"出版社版DOI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_language":"ja","subitem_relation_name_text":"10.21037/tlcr.2019.08.07"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://doi.org/10.21037/tlcr.2019.08.07","subitem_relation_type_select":"DOI"}}]},"item_1723180141928":{"attribute_name":"EID","attribute_value_mlt":[{"subitem_identifier_type":"URI","subitem_identifier_uri":"364931"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"ヨシムラ, アキヒロ","creatorNameLang":"ja"},{"creatorName":"ヨシムラ, アキヒロ","creatorNameLang":"ja-Kana"},{"creatorName":"Yoshimura, Akihiro","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"ヤマダ, タダアキ","creatorNameLang":"ja"},{"creatorName":"ヤマダ, タダアキ","creatorNameLang":"ja-Kana"},{"creatorName":"Yamada, Tadaaki","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"オオクマ, ユウスケ","creatorNameLang":"ja"},{"creatorName":"オオクマ, ユウスケ","creatorNameLang":"ja-Kana"},{"creatorName":"Okuma, Yusuke","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"キタダイ, ルイ","creatorNameLang":"ja"},{"creatorName":"キタダイ, ルイ","creatorNameLang":"ja-Kana"},{"creatorName":"Kitadai, Rui","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"タケダ, タカユキ","creatorNameLang":"ja"},{"creatorName":"タケダ, タカユキ","creatorNameLang":"ja-Kana"},{"creatorName":"Takeda, Takayuki","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"カネマツ, タカノリ","creatorNameLang":"ja"},{"creatorName":"カネマツ, タカノリ","creatorNameLang":"ja-Kana"},{"creatorName":"Kanematsu, Takanori","creatorNameLang":"en"}]},{"creatorAffiliations":[{"affiliationNameIdentifiers":[{"affiliationNameIdentifier":"","affiliationNameIdentifierScheme":"ISNI","affiliationNameIdentifierURI":"http://www.isni.org/isni/"}],"affiliationNames":[{"affiliationName":"","affiliationNameLang":"ja"}]}],"creatorNames":[{"creatorName":"後東, 久嗣","creatorNameLang":"ja"},{"creatorName":"ゴトウ, ヒサツグ","creatorNameLang":"ja-Kana"},{"creatorName":"Goto, Hisatsugu","creatorNameLang":"en"}],"familyNames":[{"familyName":"後東","familyNameLang":"ja"},{"familyName":"ゴトウ","familyNameLang":"ja-Kana"},{"familyName":"Goto","familyNameLang":"en"}],"givenNames":[{"givenName":"久嗣","givenNameLang":"ja"},{"givenName":"ヒサツグ","givenNameLang":"ja-Kana"},{"givenName":"Hisatsugu","givenNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"209","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"00437641","nameIdentifierScheme":"e-Rad","nameIdentifierURI":"https://nrid.nii.ac.jp/ja/search/?qm=00437641"}]},{"creatorNames":[{"creatorName":"米田, 浩人","creatorNameLang":"ja"},{"creatorName":"ヨネダ, ヒロト","creatorNameLang":"ja-Kana"},{"creatorName":"Yoneda, Hiroto","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"ハラダ, タイシ","creatorNameLang":"ja"},{"creatorName":"ハラダ, タイシ","creatorNameLang":"ja-Kana"},{"creatorName":"Harada, 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ユウスケ","creatorNameLang":"ja"},{"creatorName":"チハラ, ユウスケ","creatorNameLang":"ja-Kana"},{"creatorName":"Chihara, Yusuke","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"カネコ, ヨシコ","creatorNameLang":"ja"},{"creatorName":"カネコ, ヨシコ","creatorNameLang":"ja-Kana"},{"creatorName":"Kaneko, Yoshiko","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"ウチノ, ジュンジ","creatorNameLang":"ja"},{"creatorName":"ウチノ, ジュンジ","creatorNameLang":"ja-Kana"},{"creatorName":"Uchino, Junji","creatorNameLang":"en"}]},{"creatorAffiliations":[{"affiliationNameIdentifiers":[{"affiliationNameIdentifierScheme":"ISNI","affiliationNameIdentifierURI":"http://www.isni.org/isni/"}],"affiliationNames":[{"affiliationNameLang":"ja"}]}],"creatorNames":[{"creatorName":"西岡, 安彦","creatorNameLang":"ja"},{"creatorName":"ニシオカ, ヤスヒコ","creatorNameLang":"ja-Kana"},{"creatorName":"Nishioka, Yasuhiko","creatorNameLang":"en"}],"familyNames":[{"familyName":"西岡","familyNameLang":"ja"},{"familyName":"ニシオカ","familyNameLang":"ja-Kana"},{"familyName":"Nishioka","familyNameLang":"en"}],"givenNames":[{"givenName":"安彦","givenNameLang":"ja"},{"givenName":"ヤスヒコ","givenNameLang":"ja-Kana"},{"givenName":"Yasuhiko","givenNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"1542","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"60062/profile-ja.html","nameIdentifierScheme":"徳島大学 教育研究者総覧","nameIdentifierURI":"http://pub2.db.tokushima-u.ac.jp/ERD/person/60062/profile-ja.html"},{"nameIdentifier":"70274199","nameIdentifierScheme":"e-Rad_Researcher","nameIdentifierURI":"https://nrid.nii.ac.jp/ja/search/?qm=70274199"}]},{"creatorNames":[{"creatorName":"タカヤマ, コウイチ","creatorNameLang":"ja"},{"creatorName":"タカヤマ, コウイチ","creatorNameLang":"ja-Kana"},{"creatorName":"Takayama, Koichi","creatorNameLang":"en"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_access","date":[{"dateType":"Available","dateValue":"2021-12-02"}],"displaytype":"detail","filename":"tlcr_8_4_450.pdf","filesize":[{"value":"879 KB"}],"format":"application/pdf","licensetype":"license_5","mimetype":"application/pdf","url":{"objectType":"fulltext","url":"https://tokushima-u.repo.nii.ac.jp/record/2009376/files/tlcr_8_4_450.pdf"},"version_id":"33f7a65d-80b7-4bfc-bbdb-e8ee71f2e147"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"Docetaxel (Doc)","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"ramucirumab (Ram)","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"programmed death-ligand 1","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"non-small cell lung cancer (NSCLC)","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"retrospective study","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Retrospective analysis of docetaxel in combination with ramucirumab for previously treated non-small cell lung cancer patients","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Retrospective analysis of docetaxel in combination with ramucirumab for previously treated non-small cell lung cancer patients","subitem_title_language":"en"}]},"item_type_id":"40001","owner":"7","path":["1713853295607"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2021-12-02"},"publish_date":"2021-12-02","publish_status":"0","recid":"2009376","relation_version_is_last":true,"title":["Retrospective analysis of docetaxel in combination with ramucirumab for previously treated non-small cell lung cancer patients"],"weko_creator_id":"7","weko_shared_id":-1},"updated":"2025-02-10T06:19:24.227255+00:00"}