{"created":"2024-12-12T01:37:38.151014+00:00","id":2009387,"links":{},"metadata":{"_buckets":{"deposit":"5db9ef54-3958-497c-9ed4-eba7939fa642"},"_deposit":{"created_by":7,"id":"2009387","owners":[7],"pid":{"revision_id":0,"type":"depid","value":"2009387"},"status":"published"},"_oai":{"id":"oai:tokushima-u.repo.nii.ac.jp:02009387","sets":["1713853213384:1713853295607"]},"author_link":["1586"],"control_number":"2009387","item_10001_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2020-07-12","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"11","bibliographicPageStart":"140495","bibliographicVolumeNumber":"1868","bibliographic_titles":[{"bibliographic_title":"Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics","bibliographic_titleLang":"en"}]}]},"item_10001_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"This review focuses on the Cbl-b muscle atrophy-associated ubiquitin ligase and its inhibitors. Herein, the role of E3 ubiquitin ligase-associated muscle atrophy genes (atrogenes), including MAFbx-1/agrogin-1 and MuRF-1, as well as another ubiquitin ligase, Cbl-b and its inhibitors, is discussed. Cbl-b plays an important role in unloading muscle atrophy caused by spaceflight and in bedridden patients: Cbl-b ubiquitinated and induced the degradation of IRS-1, a key intermediate in the IGF-1 signaling. Furthermore, a pentapetpide (DGpYMP), inhibited Cbl-b-mediated IRS-1 ubiquitination. This peptide-based Cbl-b inhibitor Cblin and its homologous peptides in foods presumably affect muscle atrophy under such conditions.","subitem_description_language":"en","subitem_description_type":"Abstract"}]},"item_10001_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Elsevier","subitem_publisher_language":"en"}]},"item_10001_rights_15":{"attribute_name":"権利情報","attribute_value_mlt":[{"subitem_rights":"This is an open access article under the CC BY-NC-ND license (https://creativecommons.org/licenses/by-nc-nd/4.0/).","subitem_rights_language":"en"}]},"item_10001_source_id_9":{"attribute_name":"収録物ID","attribute_value_mlt":[{"subitem_source_identifier":"15709639","subitem_source_identifier_type":"ISSN"},{"subitem_source_identifier":"AA11685085","subitem_source_identifier_type":"NCID"},{"subitem_source_identifier":"AA11966765","subitem_source_identifier_type":"NCID"}]},"item_10001_version_type_20":{"attribute_name":"出版タイプ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_1715043197608":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"open access"}]},"item_1722929371688":{"attribute_name":"出版社版DOI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_language":"ja","subitem_relation_name_text":"10.1016/j.bbapap.2020.140495"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://doi.org/10.1016/j.bbapap.2020.140495","subitem_relation_type_select":"DOI"}}]},"item_1723180141928":{"attribute_name":"EID","attribute_value_mlt":[{"subitem_identifier_type":"URI","subitem_identifier_uri":"378522"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorAffiliations":[{"affiliationNameIdentifiers":[{"affiliationNameIdentifier":"","affiliationNameIdentifierScheme":"ISNI","affiliationNameIdentifierURI":"http://www.isni.org/isni/"}],"affiliationNames":[{"affiliationName":"","affiliationNameLang":"ja"}]}],"creatorNames":[{"creatorName":"二川, 健","creatorNameLang":"ja"},{"creatorName":"ニカワ, タケシ","creatorNameLang":"ja-Kana"},{"creatorName":"Nikawa, Takeshi","creatorNameLang":"en"}],"familyNames":[{"familyName":"二川","familyNameLang":"ja"},{"familyName":"ニカワ","familyNameLang":"ja-Kana"},{"familyName":"Nikawa","familyNameLang":"en"}],"givenNames":[{"givenName":"健","givenNameLang":"ja"},{"givenName":"タケシ","givenNameLang":"ja-Kana"},{"givenName":"Takeshi","givenNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"1586","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"60150/profile-ja.html","nameIdentifierScheme":"徳島大学 教育研究者総覧","nameIdentifierURI":"http://pub2.db.tokushima-u.ac.jp/ERD/person/60150/profile-ja.html"},{"nameIdentifier":"20263824","nameIdentifierScheme":"e-Rad","nameIdentifierURI":"https://nrid.nii.ac.jp/ja/search/?qm=20263824"}]},{"creatorNames":[{"creatorName":"イシドウ, カズミ","creatorNameLang":"ja"},{"creatorName":"イシドウ, カズミ","creatorNameLang":"ja-Kana"},{"creatorName":"Ishidoh, Kazumi","creatorNameLang":"en"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_access","date":[{"dateType":"Available","dateValue":"2021-12-03"}],"displaytype":"detail","filename":"bbapap_1868_11_140495.pdf","filesize":[{"value":"1.33 MB"}],"format":"application/pdf","licensetype":"license_5","mimetype":"application/pdf","url":{"objectType":"fulltext","url":"https://tokushima-u.repo.nii.ac.jp/record/2009387/files/bbapap_1868_11_140495.pdf"},"version_id":"680650f4-7f71-4862-aea4-0afea6783b2a"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"MAFbx-1/atrogin-1","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"MuRF-1","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Cbl-b","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Cblin","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Muscle atrophy","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Ubiquitin ligase Cbl-b and inhibitory Cblin peptides","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Ubiquitin ligase Cbl-b and inhibitory Cblin peptides","subitem_title_language":"en"}]},"item_type_id":"40001","owner":"7","path":["1713853295607"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2021-12-03"},"publish_date":"2021-12-03","publish_status":"0","recid":"2009387","relation_version_is_last":true,"title":["Ubiquitin ligase Cbl-b and inhibitory Cblin peptides"],"weko_creator_id":"7","weko_shared_id":-1},"updated":"2025-01-28T08:20:53.163057+00:00"}