{"created":"2024-12-12T01:39:45.859700+00:00","id":2009414,"links":{},"metadata":{"_buckets":{"deposit":"111d744d-b367-4661-828a-20bf4cc7d250"},"_deposit":{"created_by":7,"id":"2009414","owners":[7],"pid":{"revision_id":0,"type":"depid","value":"2009414"},"status":"published"},"_oai":{"id":"oai:tokushima-u.repo.nii.ac.jp:02009414","sets":["1713853213384:1713853295607"]},"author_link":["1190"],"control_number":"2009414","item_10001_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2021-04-27","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"4","bibliographicPageStart":"109032","bibliographicVolumeNumber":"35","bibliographic_titles":[{"bibliographic_title":"Cell Reports","bibliographic_titleLang":"en"}]}]},"item_10001_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"X chromosome inactivation (XCI) is a dosage compensation mechanism in female mammals whereby transcription from one X chromosome is repressed. Analysis of human induced pluripotent stem cells (iPSCs) derived from female donors identified that low levels of XIST RNA correlated strongly with erosion of XCI. Proteomic analysis, RNA sequencing (RNA-seq), and polysome profiling showed that XCI erosion resulted in amplified RNA and protein expression from X-linked genes, providing a proteomic characterization of skewed dosage compensation. Increased protein expression was also detected from autosomal genes without an mRNA increase, thus altering the protein-RNA correlation between the X chromosome and autosomes. XCI-eroded lines display an ∼13% increase in total cell protein content, with increased ribosomal proteins, ribosome biogenesis and translation factors, and polysome levels. We conclude that XCI erosion in iPSCs causes a remodeling of the proteome, affecting the expression of a much wider range of proteins and disease-linked loci than previously realized.","subitem_description_language":"en","subitem_description_type":"Abstract"}]},"item_10001_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Elsevier","subitem_publisher_language":"en"}]},"item_10001_rights_15":{"attribute_name":"権利情報","attribute_value_mlt":[{"subitem_rights":"This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).","subitem_rights_language":"en"}]},"item_10001_source_id_9":{"attribute_name":"収録物ID","attribute_value_mlt":[{"subitem_source_identifier":"22111247","subitem_source_identifier_type":"ISSN"}]},"item_10001_version_type_20":{"attribute_name":"出版タイプ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_1715043197608":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"open access"}]},"item_1722929371688":{"attribute_name":"出版社版DOI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_language":"ja","subitem_relation_name_text":"10.1016/j.celrep.2021.109032"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://doi.org/10.1016/j.celrep.2021.109032","subitem_relation_type_select":"DOI"}}]},"item_1723180141928":{"attribute_name":"EID","attribute_value_mlt":[{"subitem_identifier_type":"URI","subitem_identifier_uri":"376409"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Brenes, Alejandro J.","creatorNameLang":"en"}]},{"creatorAffiliations":[{"affiliationNameIdentifiers":[{"affiliationNameIdentifier":"","affiliationNameIdentifierScheme":"ISNI","affiliationNameIdentifierURI":"http://www.isni.org/isni/"}],"affiliationNames":[{"affiliationName":"","affiliationNameLang":"ja"}]}],"creatorNames":[{"creatorName":"𠮷川, 治孝","creatorNameLang":"ja"},{"creatorName":"ヨシカワ, ハルノリ","creatorNameLang":"ja-Kana"},{"creatorName":"Yoshikawa, Harunori","creatorNameLang":"en"}],"familyNames":[{"familyName":"𠮷川","familyNameLang":"ja"},{"familyName":"ヨシカワ","familyNameLang":"ja-Kana"},{"familyName":"Yoshikawa","familyNameLang":"en"}],"givenNames":[{"givenName":"治孝","givenNameLang":"ja"},{"givenName":"ハルノリ","givenNameLang":"ja-Kana"},{"givenName":"Harunori","givenNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"1190","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"371756/profile-ja.html","nameIdentifierScheme":"徳島大学 教育研究者総覧","nameIdentifierURI":"http://pub2.db.tokushima-u.ac.jp/ERD/person/371756/profile-ja.html"},{"nameIdentifier":"60709567","nameIdentifierScheme":"e-Rad","nameIdentifierURI":"https://nrid.nii.ac.jp/ja/search/?qm=60709567"}]},{"creatorNames":[{"creatorName":"Bensaddek, Dalila","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Mirauta, Bogdan","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Seaton, Daniel","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Hukelmann, Jens L.","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Jiang, Hao","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Stegle, Oliver","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Lamond, Angus I.","creatorNameLang":"en"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_access","date":[{"dateType":"Available","dateValue":"2021-12-07"}],"displaytype":"detail","filename":"celrep_35_4_109032.pdf","filesize":[{"value":"4.66 MB"}],"format":"application/pdf","licensetype":"license_0","mimetype":"application/pdf","url":{"objectType":"fulltext","url":"https://tokushima-u.repo.nii.ac.jp/record/2009414/files/celrep_35_4_109032.pdf"},"version_id":"66a95bf6-c33a-4f78-bd1c-7c9255675eaf"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Erosion of human X chromosome inactivation causes major remodeling of the iPSC proteome","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Erosion of human X chromosome inactivation causes major remodeling of the iPSC proteome","subitem_title_language":"en"}]},"item_type_id":"40001","owner":"7","path":["1713853295607"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2021-12-07"},"publish_date":"2021-12-07","publish_status":"0","recid":"2009414","relation_version_is_last":true,"title":["Erosion of human X chromosome inactivation causes major remodeling of the iPSC proteome"],"weko_creator_id":"7","weko_shared_id":-1},"updated":"2025-02-13T04:57:25.929751+00:00"}