{"created":"2024-12-12T01:40:38.311884+00:00","id":2009425,"links":{},"metadata":{"_buckets":{"deposit":"a05fd7a2-7734-47ec-88b5-05198793f717"},"_deposit":{"created_by":7,"id":"2009425","owners":[7],"pid":{"revision_id":0,"type":"depid","value":"2009425"},"status":"published"},"_oai":{"id":"oai:tokushima-u.repo.nii.ac.jp:02009425","sets":["1713853213384:1713853295607"]},"author_link":["415"],"control_number":"2009425","item_10001_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2020-08-25","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"2","bibliographicPageEnd":"256","bibliographicPageStart":"249","bibliographicVolumeNumber":"22","bibliographic_titles":[{"bibliographic_title":"Expert Opinion on Pharmacotherapy","bibliographic_titleLang":"en"}]}]},"item_10001_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Background: With limited real-world insulin glargine 300 U/mL (Gla-300) data among Japanese patients with type 1 diabetes mellitus (T1DM) available, the authors describe its effectiveness and safety in Japanese T1DM patients switching to Gla-300.\nResearch design and methods: X-STAR was a 12-month prospective, observational, post-marketing study in Japanese patients with diabetes mellitus from 2015 to 2018: insulin-experienced T1DM patients initiating Gla-300 were analyzed.\nResults: Of 774 patients, mean (±standard deviation) HbA1c (%) and fasting plasma glucose (mg/dL) decreased from 8.27 ± 1.55 to 8.15 ± 1.35 (by −0.12 ± 1.30 [p = 0.013]) and 167.9 ± 92.6 to 153.9 ± 70.9 (by −13.9 ± 103.8 [p = 0.067]) from baseline to month 12, respectively. A total of 16.3% achieved HbA1c <7.0% at month 12. Gla-300 dose increased by 1.13 ± 3.18 U/day (0.02 ± 0.05 U/kg/day) (p < 0.001), with a + 0.22 ± 2.70 (p = 0.037) body-weight change (kg) from baseline 60.83 ± 12.81 to 12-month 61.06 ± 12.89. Adverse drug reactions (ADRs) and serious ADRs occurred in 9.82% and 0.78% of the patients, respectively. Hypoglycemia was the most common ADR (9.30%). In total, 88.9% adhered to Gla-300 administration schedules, whereas <40% adhered to exercise and dietary instructions, respectively.\nConclusions: Gla-300 showed no unprecedented safety concerns for insulin-experienced T1DM patients in Japanese clinical settings. Our results provide insights into strategies for blunted Gla-300 up-titration dose, despite insufficient HbA1c control and lifestyle modification.","subitem_description_language":"en","subitem_description_type":"Abstract"}]},"item_10001_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Taylor & Francis","subitem_publisher_language":"en"}]},"item_10001_rights_15":{"attribute_name":"権利情報","attribute_value_mlt":[{"subitem_rights":"This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivatives License (http://creativecommons.org/licenses/by-nc-nd/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited, and is not altered, transformed, or built upon in any way.","subitem_rights_language":"en"}]},"item_10001_source_id_9":{"attribute_name":"収録物ID","attribute_value_mlt":[{"subitem_source_identifier":"14656566","subitem_source_identifier_type":"ISSN"},{"subitem_source_identifier":"17447666","subitem_source_identifier_type":"ISSN"},{"subitem_source_identifier":"AA11692615","subitem_source_identifier_type":"NCID"},{"subitem_source_identifier":"AA12796310","subitem_source_identifier_type":"NCID"}]},"item_10001_version_type_20":{"attribute_name":"出版タイプ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_1715043197608":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"open access"}]},"item_1722929371688":{"attribute_name":"出版社版DOI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_language":"ja","subitem_relation_name_text":"10.1080/14656566.2020.1810665"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://doi.org/10.1080/14656566.2020.1810665","subitem_relation_type_select":"DOI"}}]},"item_1723180141928":{"attribute_name":"EID","attribute_value_mlt":[{"subitem_identifier_type":"URI","subitem_identifier_uri":"376758"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorAffiliations":[{"affiliationNameIdentifiers":[{"affiliationNameIdentifier":"","affiliationNameIdentifierScheme":"ISNI","affiliationNameIdentifierURI":"http://www.isni.org/isni/"}],"affiliationNames":[{"affiliationName":"","affiliationNameLang":"ja"}]}],"creatorNames":[{"creatorName":"松久, 宗英","creatorNameLang":"ja"},{"creatorName":"マツヒサ, ムネヒデ","creatorNameLang":"ja-Kana"},{"creatorName":"Matsuhisa, Munehide","creatorNameLang":"en"}],"familyNames":[{"familyName":"松久","familyNameLang":"ja"},{"familyName":"マツヒサ","familyNameLang":"ja-Kana"},{"familyName":"Matsuhisa","familyNameLang":"en"}],"givenNames":[{"givenName":"宗英","givenNameLang":"ja"},{"givenName":"ムネヒデ","givenNameLang":"ja-Kana"},{"givenName":"Munehide","givenNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"415","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"205776/profile-ja.html","nameIdentifierScheme":"徳島大学 教育研究者総覧","nameIdentifierURI":"http://pub2.db.tokushima-u.ac.jp/ERD/person/205776/profile-ja.html"},{"nameIdentifier":"60362737","nameIdentifierScheme":"e-Rad","nameIdentifierURI":"https://nrid.nii.ac.jp/ja/search/?qm=60362737"}]},{"creatorNames":[{"creatorName":"オダワラ, マサト","creatorNameLang":"ja"},{"creatorName":"オダワラ, マサト","creatorNameLang":"ja-Kana"},{"creatorName":"Odawara, Masato","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"ヒロセ, タカヒサ","creatorNameLang":"ja"},{"creatorName":"ヒロセ, タカヒサ","creatorNameLang":"ja-Kana"},{"creatorName":"Hirose, Takahisa","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"コシダ, リュウスケ","creatorNameLang":"ja"},{"creatorName":"コシダ, リュウスケ","creatorNameLang":"ja-Kana"},{"creatorName":"Koshida, Ryusuke","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"センダ, マサユキ","creatorNameLang":"ja"},{"creatorName":"センダ, マサユキ","creatorNameLang":"ja-Kana"},{"creatorName":"Senda, Masayuki","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"タナカ, ヤスシ","creatorNameLang":"ja"},{"creatorName":"タナカ, ヤスシ","creatorNameLang":"ja-Kana"},{"creatorName":"Tanaka, Yasushi","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"テラウチ, ヤスオ","creatorNameLang":"ja"},{"creatorName":"テラウチ, ヤスオ","creatorNameLang":"ja-Kana"},{"creatorName":"Terauchi, Yasuo","creatorNameLang":"en"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_access","date":[{"dateType":"Available","dateValue":"2021-12-22"}],"displaytype":"detail","filename":"eop_22_2_249.pdf","filesize":[{"value":"836 KB"}],"format":"application/pdf","licensetype":"license_5","mimetype":"application/pdf","url":{"objectType":"fulltext","url":"https://tokushima-u.repo.nii.ac.jp/record/2009425/files/eop_22_2_249.pdf"},"version_id":"1c7df56d-4824-4e76-8566-0a51da9d9010"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"Basal insulin","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Japanese","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"post-marketing surveillance study","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"type 1 diabetes mellitus","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Real-world data on the use of insulin glargine 300 U/mL in Japanese patients with type 1 diabetes : twelve-month results from a post-marketing surveillance study (X-STAR study)","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Real-world data on the use of insulin glargine 300 U/mL in Japanese patients with type 1 diabetes : twelve-month results from a post-marketing surveillance study (X-STAR study)","subitem_title_language":"en"}]},"item_type_id":"40001","owner":"7","path":["1713853295607"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2021-12-22"},"publish_date":"2021-12-22","publish_status":"0","recid":"2009425","relation_version_is_last":true,"title":["Real-world data on the use of insulin glargine 300 U/mL in Japanese patients with type 1 diabetes : twelve-month results from a post-marketing surveillance study (X-STAR study)"],"weko_creator_id":"7","weko_shared_id":-1},"updated":"2025-01-29T07:18:48.897438+00:00"}