{"created":"2024-12-12T01:42:08.462404+00:00","id":2009444,"links":{},"metadata":{"_buckets":{"deposit":"8eb305cc-c0cc-4755-9740-1016b423fb7a"},"_deposit":{"created_by":7,"id":"2009444","owners":[7],"pid":{"revision_id":0,"type":"depid","value":"2009444"},"status":"published"},"_oai":{"id":"oai:tokushima-u.repo.nii.ac.jp:02009444","sets":["1713829974766:1713854681789:1716364513618:1716365191274","1713853213384:1713853295607"]},"author_link":["265","621","1391","792","702","1266","193","1253"],"control_number":"2009444","item_10001_alternative_title_1":{"attribute_name":"タイトル別表記","attribute_value_mlt":[{"subitem_alternative_title":"Schwann-like cells from ADSCs using folic acid","subitem_alternative_title_language":"en"}]},"item_10001_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2021-08","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"3-4","bibliographicPageEnd":"353","bibliographicPageStart":"347","bibliographicVolumeNumber":"68","bibliographic_titles":[{"bibliographic_title":"The Journal of Medical Investigation","bibliographic_titleLang":"en"}]}]},"item_10001_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Peripheral nerve injury (PNI) after pelvic surgery is a common issue with a significant impact on patients. Autologous nerve grafting is the gold standard treatment for PNI, but this technique cannot be applied to fine nerve fibers in the pelvis. Schwann-like cell (SLC) differentiation is a novel therapeutic strategy for this clinical condition. However, the efficiency of SLC differentiation remains unsatisfactory. We modified an SLC differentiation protocol using adipose-derived stem cells (ADSCs) and folic acid. Morphology, gene expression and secretion of neurotrophic factors were examined to assess the differentiation quality and phenotypic characteristics. Our new modified protocol effectively induced a Schwann cell (SC) phenotype in ADSCs as assessed by morphology and expression of SC markers [S100 calcium-binding protein B (S100B), P < 0.01 ; p75 neurotrophic receptor (p75NTR), P < 0.05]. SLCs produced by the new protocol displayed a repair phenotype with decreased expression of ERBB2 and early growth response protein 2 (EGR2) / KROX20 (P < 0.01). Furthermore, our new protocol enhanced both mRNA expression and secretion of nerve growth factors by SLCs (P < 0.01). This protocol enhanced the SC characteristics and functions of ADSC-derived SLCs. This promising protocol requires further research and may contribute to SC-based nerve regeneration.","subitem_description_language":"en","subitem_description_type":"Abstract"}]},"item_10001_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Tokushima University Faculty of Medicine","subitem_publisher_language":"en"}]},"item_10001_source_id_9":{"attribute_name":"収録物ID","attribute_value_mlt":[{"subitem_source_identifier":"13496867","subitem_source_identifier_type":"ISSN"},{"subitem_source_identifier":"13431420","subitem_source_identifier_type":"ISSN"},{"subitem_source_identifier":"AA11166929","subitem_source_identifier_type":"NCID"}]},"item_10001_version_type_20":{"attribute_name":"出版タイプ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_1715043197608":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"open access"}]},"item_1722929371688":{"attribute_name":"出版社版DOI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_language":"ja","subitem_relation_name_text":"10.2152/jmi.68.347"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://doi.org/10.2152/jmi.68.347","subitem_relation_type_select":"DOI"}}]},"item_1723180141928":{"attribute_name":"EID","attribute_value_mlt":[{"subitem_identifier_type":"URI","subitem_identifier_uri":"386671"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Chen, Shuhai","creatorNameLang":"en"}]},{"creatorAffiliations":[{"affiliationNameIdentifiers":[{"affiliationNameIdentifierScheme":"ISNI","affiliationNameIdentifierURI":"http://www.isni.org/isni/"}],"affiliationNames":[{"affiliationNameLang":"ja"}]}],"creatorNames":[{"creatorName":"池本, 哲也","creatorNameLang":"ja"},{"creatorName":"イケモト, テツヤ","creatorNameLang":"ja-Kana"},{"creatorName":"Ikemoto, Tetsuya","creatorNameLang":"en"}],"familyNames":[{"familyName":"池本","familyNameLang":"ja"},{"familyName":"イケモト","familyNameLang":"ja-Kana"},{"familyName":"Ikemoto","familyNameLang":"en"}],"givenNames":[{"givenName":"哲也","givenNameLang":"ja"},{"givenName":"テツヤ","givenNameLang":"ja-Kana"},{"givenName":"Tetsuya","givenNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"265","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"157341/profile-ja.html","nameIdentifierScheme":"徳島大学 教育研究者総覧","nameIdentifierURI":"http://pub2.db.tokushima-u.ac.jp/ERD/person/157341/profile-ja.html"},{"nameIdentifier":"20398019","nameIdentifierScheme":"e-Rad_Researcher","nameIdentifierURI":"https://nrid.nii.ac.jp/ja/search/?qm=20398019"}]},{"creatorAffiliations":[{"affiliationNameIdentifiers":[{"affiliationNameIdentifierScheme":"ISNI","affiliationNameIdentifierURI":"http://www.isni.org/isni/"}],"affiliationNames":[{"affiliationNameLang":"ja"}]}],"creatorNames":[{"creatorName":"徳永, 卓哉","creatorNameLang":"ja"},{"creatorName":"トクナガ, タクヤ","creatorNameLang":"ja-Kana"},{"creatorName":"Tokunaga, Takuya","creatorNameLang":"en"}],"familyNames":[{"familyName":"徳永","familyNameLang":"ja"},{"familyName":"トクナガ","familyNameLang":"ja-Kana"},{"familyName":"Tokunaga","familyNameLang":"en"}],"givenNames":[{"givenName":"卓哉","givenNameLang":"ja"},{"givenName":"タクヤ","givenNameLang":"ja-Kana"},{"givenName":"Takuya","givenNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"621","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"261398/profile-ja.html","nameIdentifierScheme":"徳島大学 教育研究者総覧","nameIdentifierURI":"http://pub2.db.tokushima-u.ac.jp/ERD/person/261398/profile-ja.html"},{"nameIdentifier":"30448328","nameIdentifierScheme":"e-Rad_Researcher","nameIdentifierURI":"https://nrid.nii.ac.jp/ja/search/?qm=30448328"}]},{"creatorNames":[{"creatorName":"オキカワ, ショウヘイ","creatorNameLang":"ja"},{"creatorName":"オキカワ, ショウヘイ","creatorNameLang":"ja-Kana"},{"creatorName":"Okikawa, Shohei","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"宮崎, 克己","creatorNameLang":"ja"},{"creatorName":"ミヤザキ, カツキ","creatorNameLang":"ja-Kana"},{"creatorName":"Miyazaki, Katsuki","creatorNameLang":"en"}],"familyNames":[{"familyName":"宮崎","familyNameLang":"ja"},{"familyName":"ミヤザキ","familyNameLang":"ja-Kana"},{"familyName":"Miyazaki","familyNameLang":"en"}],"givenNames":[{"givenName":"克己","givenNameLang":"ja"},{"givenName":"カツキ","givenNameLang":"ja-Kana"},{"givenName":"Katsuki","givenNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"1391","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"361217/profile-ja.html","nameIdentifierScheme":"徳島大学 教育研究者総覧","nameIdentifierURI":"http://pub2.db.tokushima-u.ac.jp/ERD/person/361217/profile-ja.html"},{"nameIdentifier":"30846126","nameIdentifierScheme":"e-Rad_Researcher","nameIdentifierURI":"https://nrid.nii.ac.jp/ja/search/?qm=30846126"}]},{"creatorNames":[{"creatorName":"トクダ, カズノリ","creatorNameLang":"ja"},{"creatorName":"トクダ, カズノリ","creatorNameLang":"ja-Kana"},{"creatorName":"Tokuda, Kazunori","creatorNameLang":"en"}]},{"creatorAffiliations":[{"affiliationNameIdentifiers":[{"affiliationNameIdentifierScheme":"ISNI","affiliationNameIdentifierURI":"http://www.isni.org/isni/"}],"affiliationNames":[{"affiliationNameLang":"ja"}]}],"creatorNames":[{"creatorName":"山田, 眞一郎","creatorNameLang":"ja"},{"creatorName":"ヤマダ, シンイチロウ","creatorNameLang":"ja-Kana"},{"creatorName":"Yamada, Shin-ichiro","creatorNameLang":"en"}],"familyNames":[{"familyName":"山田","familyNameLang":"ja"},{"familyName":"ヤマダ","familyNameLang":"ja-Kana"},{"familyName":"Yamada","familyNameLang":"en"}],"givenNames":[{"givenName":"眞一郎","givenNameLang":"ja"},{"givenName":"シンイチロウ","givenNameLang":"ja-Kana"},{"givenName":"Shin-ichiro","givenNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"792","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"294064/profile-ja.html","nameIdentifierScheme":"徳島大学 教育研究者総覧","nameIdentifierURI":"http://pub2.db.tokushima-u.ac.jp/ERD/person/294064/profile-ja.html"},{"nameIdentifier":"30579884","nameIdentifierScheme":"e-Rad_Researcher","nameIdentifierURI":"https://nrid.nii.ac.jp/ja/search/?qm=30579884"}]},{"creatorAffiliations":[{"affiliationNameIdentifiers":[{"affiliationNameIdentifierScheme":"ISNI","affiliationNameIdentifierURI":"http://www.isni.org/isni/"}],"affiliationNames":[{"affiliationNameLang":"ja"}]}],"creatorNames":[{"creatorName":"齋藤, 裕","creatorNameLang":"ja"},{"creatorName":"サイトウ, ユウ","creatorNameLang":"ja-Kana"},{"creatorName":"Saitou, Yu","creatorNameLang":"en"}],"familyNames":[{"familyName":"齋藤","familyNameLang":"ja"},{"familyName":"サイトウ","familyNameLang":"ja-Kana"},{"familyName":"Saitou","familyNameLang":"en"}],"givenNames":[{"givenName":"裕","givenNameLang":"ja"},{"givenName":"ユウ","givenNameLang":"ja-Kana"},{"givenName":"Yu","givenNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"702","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"277637/profile-ja.html","nameIdentifierScheme":"徳島大学 教育研究者総覧","nameIdentifierURI":"http://pub2.db.tokushima-u.ac.jp/ERD/person/277637/profile-ja.html"},{"nameIdentifier":"50548675","nameIdentifierScheme":"e-Rad_Researcher","nameIdentifierURI":"https://nrid.nii.ac.jp/ja/search/?qm=50548675"}]},{"creatorAffiliations":[{"affiliationNameIdentifiers":[{"affiliationNameIdentifierScheme":"ISNI","affiliationNameIdentifierURI":"http://www.isni.org/isni/"}],"affiliationNames":[{"affiliationNameLang":"ja"}]}],"creatorNames":[{"creatorName":"居村, 暁","creatorNameLang":"ja"},{"creatorName":"イムラ, サトル","creatorNameLang":"ja-Kana"},{"creatorName":"Imura, Satoru","creatorNameLang":"en"}],"familyNames":[{"familyName":"居村","familyNameLang":"ja"},{"familyName":"イムラ","familyNameLang":"ja-Kana"},{"familyName":"Imura","familyNameLang":"en"}],"givenNames":[{"givenName":"暁","givenNameLang":"ja"},{"givenName":"サトル","givenNameLang":"ja-Kana"},{"givenName":"Satoru","givenNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"1266","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"90380021","nameIdentifierScheme":"e-Rad_Researcher","nameIdentifierURI":"https://nrid.nii.ac.jp/ja/search/?qm=90380021"}]},{"creatorAffiliations":[{"affiliationNameIdentifiers":[{"affiliationNameIdentifierScheme":"ISNI","affiliationNameIdentifierURI":"http://www.isni.org/isni/"}],"affiliationNames":[{"affiliationNameLang":"ja"}]}],"creatorNames":[{"creatorName":"森根, 裕二","creatorNameLang":"ja"},{"creatorName":"モリネ, ユウジ","creatorNameLang":"ja-Kana"},{"creatorName":"Morine, Yuji","creatorNameLang":"en"}],"familyNames":[{"familyName":"森根","familyNameLang":"ja"},{"familyName":"モリネ","familyNameLang":"ja-Kana"},{"familyName":"Morine","familyNameLang":"en"}],"givenNames":[{"givenName":"裕二","givenNameLang":"ja"},{"givenName":"ユウジ","givenNameLang":"ja-Kana"},{"givenName":"Yuji","givenNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"193","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"121751/profile-ja.html","nameIdentifierScheme":"徳島大学 教育研究者総覧","nameIdentifierURI":"http://pub2.db.tokushima-u.ac.jp/ERD/person/121751/profile-ja.html"},{"nameIdentifier":"60398021","nameIdentifierScheme":"e-Rad_Researcher","nameIdentifierURI":"https://nrid.nii.ac.jp/ja/search/?qm=60398021"}]},{"creatorAffiliations":[{"affiliationNameIdentifiers":[{"affiliationNameIdentifierScheme":"ISNI","affiliationNameIdentifierURI":"http://www.isni.org/isni/"}],"affiliationNames":[{"affiliationNameLang":"ja"}]}],"creatorNames":[{"creatorName":"島田, 光生","creatorNameLang":"ja"},{"creatorName":"シマダ, ミツオ","creatorNameLang":"ja-Kana"},{"creatorName":"Shimada, Mitsuo","creatorNameLang":"en"}],"familyNames":[{"familyName":"島田","familyNameLang":"ja"},{"familyName":"シマダ","familyNameLang":"ja-Kana"},{"familyName":"Shimada","familyNameLang":"en"}],"givenNames":[{"givenName":"光生","givenNameLang":"ja"},{"givenName":"ミツオ","givenNameLang":"ja-Kana"},{"givenName":"Mitsuo","givenNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"1253","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"82712/profile-ja.html","nameIdentifierScheme":"徳島大学 教育研究者総覧","nameIdentifierURI":"http://pub2.db.tokushima-u.ac.jp/ERD/person/82712/profile-ja.html"},{"nameIdentifier":"10216070","nameIdentifierScheme":"e-Rad_Researcher","nameIdentifierURI":"https://nrid.nii.ac.jp/ja/search/?qm=10216070"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_access","date":[{"dateType":"Available","dateValue":"2021-12-03"}],"displaytype":"detail","filename":"jmi_68_3-4_347.pdf","filesize":[{"value":"582 KB"}],"format":"application/pdf","mimetype":"application/pdf","url":{"objectType":"fulltext","url":"https://tokushima-u.repo.nii.ac.jp/record/2009444/files/jmi_68_3-4_347.pdf"},"version_id":"0af3fda3-1751-4a54-861d-2adce8d51b3d"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"Adipose-derived stem cell","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Schwann-like cells","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Folic acid","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Nerve growth factor","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Regenerative medicine","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Effective in vitro differentiation of adipose-derived stem cells into Schwann-like cells with folic acid supplementation","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Effective in vitro differentiation of adipose-derived stem cells into Schwann-like cells with folic acid supplementation","subitem_title_language":"en"}]},"item_type_id":"40001","owner":"7","path":["1713853295607","1716365191274"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2021-12-03"},"publish_date":"2021-12-03","publish_status":"0","recid":"2009444","relation_version_is_last":true,"title":["Effective in vitro differentiation of adipose-derived stem cells into Schwann-like cells with folic acid supplementation"],"weko_creator_id":"7","weko_shared_id":-1},"updated":"2025-04-28T06:46:41.368273+00:00"}