{"created":"2024-12-12T01:46:44.514784+00:00","id":2009504,"links":{},"metadata":{"_buckets":{"deposit":"51e6d0ec-01fc-4bbe-962c-9429a70e0415"},"_deposit":{"created_by":7,"id":"2009504","owners":[7],"pid":{"revision_id":0,"type":"depid","value":"2009504"},"status":"published"},"_oai":{"id":"oai:tokushima-u.repo.nii.ac.jp:02009504","sets":["1713853213384:1713853295607"]},"author_link":["959"],"control_number":"2009504","item_10001_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2021-08-03","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"15","bibliographicPageStart":"4684","bibliographicVolumeNumber":"26","bibliographic_titles":[{"bibliographic_title":"Molecules","bibliographic_titleLang":"en"}]}]},"item_10001_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Allergy is an excessive immune response to a specific antigen. Type I allergies, such as hay fever and food allergies, have increased significantly in recent years and have become a worldwide problem. We previously reported that an ascorbic acid derivative having palmitoyl and glucosyl groups, 2-O-α-D-glucopyranosyl-6-O-hexadecanoyl-L-ascorbic acid (6-sPalm-AA-2G), showed inhibitory effects on degranulation in vitro and on the passive cutaneous anaphylaxis (PCA) reaction in mice. In this study, several palmitoyl derivatives of ascorbic acid were synthesized and a structure–activity relationship study was performed to discover more potent ascorbic acid derivatives with degranulation inhibitory activity. 6-Deoxy-2-O-methyl-6-(N-hexadecanoyl)amino-L-ascorbic acid (2-Me-6-N-Palm-AA), in which a methyl group was introduced into the hydroxyl group at the C-2 position of ascorbic acid and in which the hydroxyl group at the C-6 position was substituted with an N-palmitoyl group, exhibited much higher inhibitory activity for degranulation in vitro than did 6-sPalm-AA-2G. 2-Me-6-N-Palm-AA strongly inhibit the PCA reaction in mice at lower doses than those of 6-sPalm-AA-2G. These findings suggest that 2-Me-6-N-Palm-AA may be a promising therapeutic candidate for allergic diseases.","subitem_description_language":"en","subitem_description_type":"Abstract"}]},"item_10001_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"MDPI","subitem_publisher_language":"en"}]},"item_10001_rights_15":{"attribute_name":"権利情報","attribute_value_mlt":[{"subitem_rights":"This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).","subitem_rights_language":"en"}]},"item_10001_source_id_9":{"attribute_name":"収録物ID","attribute_value_mlt":[{"subitem_source_identifier":"14203049","subitem_source_identifier_type":"ISSN"}]},"item_10001_version_type_20":{"attribute_name":"出版タイプ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_1715043197608":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"open access"}]},"item_1722929371688":{"attribute_name":"出版社版DOI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_language":"ja","subitem_relation_name_text":"10.3390/molecules26154684"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://doi.org/10.3390/molecules26154684","subitem_relation_type_select":"DOI"}}]},"item_1723180141928":{"attribute_name":"EID","attribute_value_mlt":[{"subitem_identifier_type":"URI","subitem_identifier_uri":"378637"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"ミウラ, カオリ","creatorNameLang":"ja"},{"creatorName":"ミウラ, カオリ","creatorNameLang":"ja-Kana"},{"creatorName":"Miura, Kaori","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"マツノ, ヒロアキ","creatorNameLang":"ja"},{"creatorName":"マツノ, ヒロアキ","creatorNameLang":"ja-Kana"},{"creatorName":"Matsuno, Hiroaki","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"イワオカ, ユウジ","creatorNameLang":"ja"},{"creatorName":"イワオカ, ユウジ","creatorNameLang":"ja-Kana"},{"creatorName":"Iwaoka, Yuji","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"イトウ, ヒデユキ","creatorNameLang":"ja"},{"creatorName":"イトウ, ヒデユキ","creatorNameLang":"ja-Kana"},{"creatorName":"Ito, Hideyuki","creatorNameLang":"en"}]},{"creatorAffiliations":[{"affiliationNameIdentifiers":[{"affiliationNameIdentifier":"","affiliationNameIdentifierScheme":"ISNI","affiliationNameIdentifierURI":"http://www.isni.org/isni/"}],"affiliationNames":[{"affiliationName":"","affiliationNameLang":"ja"}]}],"creatorNames":[{"creatorName":"田井, 章博","creatorNameLang":"ja"},{"creatorName":"タイ, アキヒロ","creatorNameLang":"ja-Kana"},{"creatorName":"Tai, Akihiro","creatorNameLang":"en"}],"familyNames":[{"familyName":"田井","familyNameLang":"ja"},{"familyName":"タイ","familyNameLang":"ja-Kana"},{"familyName":"Tai","familyNameLang":"en"}],"givenNames":[{"givenName":"章博","givenNameLang":"ja"},{"givenName":"アキヒロ","givenNameLang":"ja-Kana"},{"givenName":"Akihiro","givenNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"959","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"350199/profile-ja.html","nameIdentifierScheme":"徳島大学 教育研究者総覧","nameIdentifierURI":"http://pub2.db.tokushima-u.ac.jp/ERD/person/350199/profile-ja.html"},{"nameIdentifier":"70284081","nameIdentifierScheme":"e-Rad","nameIdentifierURI":"https://nrid.nii.ac.jp/ja/search/?qm=70284081"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_access","date":[{"dateType":"Available","dateValue":"2022-01-28"}],"displaytype":"detail","filename":"molecules_26_15_4684.pdf","filesize":[{"value":"1.52 MB"}],"format":"application/pdf","licensetype":"license_0","mimetype":"application/pdf","url":{"objectType":"fulltext","url":"https://tokushima-u.repo.nii.ac.jp/record/2009504/files/molecules_26_15_4684.pdf"},"version_id":"12930911-0ae6-4062-b90c-b9ef19beff6f"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"ascorbic acid derivatives","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"degranulation","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"passive cutaneous anaphylaxis","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"structure-activity relationship","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Antiallergic Activity of 6-Deoxy-2-O-methyl-6-(N-hexadecanoyl)amino-L-ascorbic Acid","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Antiallergic Activity of 6-Deoxy-2-O-methyl-6-(N-hexadecanoyl)amino-L-ascorbic Acid","subitem_title_language":"en"}]},"item_type_id":"40001","owner":"7","path":["1713853295607"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2022-01-28"},"publish_date":"2022-01-28","publish_status":"0","recid":"2009504","relation_version_is_last":true,"title":["Antiallergic Activity of 6-Deoxy-2-O-methyl-6-(N-hexadecanoyl)amino-L-ascorbic Acid"],"weko_creator_id":"7","weko_shared_id":-1},"updated":"2025-01-28T04:39:54.823101+00:00"}