{"created":"2024-12-12T01:47:16.572686+00:00","id":2009510,"links":{},"metadata":{"_buckets":{"deposit":"ee01204a-a7ef-46f0-ad1f-f56d445092da"},"_deposit":{"created_by":7,"id":"2009510","owners":[7],"pid":{"revision_id":0,"type":"depid","value":"2009510"},"status":"published"},"_oai":{"id":"oai:tokushima-u.repo.nii.ac.jp:02009510","sets":["1713853213384:1713853295607"]},"author_link":["1188"],"control_number":"2009510","item_10001_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2021-01-12","bibliographicIssueDateType":"Issued"},"bibliographicPageStart":"281","bibliographicVolumeNumber":"12","bibliographic_titles":[{"bibliographic_title":"Nature Communications","bibliographic_titleLang":"en"}]}]},"item_10001_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"A functional association is uncovered between the ribosome-associated trigger factor (TF) chaperone and the ClpXP degradation complex. Bioinformatic analyses demonstrate conservation of the close proximity of tig, the gene coding for TF, and genes coding for ClpXP, suggesting a functional interaction. The effect of TF on ClpXP-dependent degradation varies based on the nature of substrate. While degradation of some substrates are slowed down or are unaffected by TF, surprisingly, TF increases the degradation rate of a third class of substrates. These include λ phage replication protein λO, master regulator of stationary phase RpoS, and SsrA-tagged proteins. Globally, TF acts to enhance the degradation of about 2% of newly synthesized proteins. TF is found to interact through multiple sites with ClpX in a highly dynamic fashion to promote protein degradation. This chaperone–protease cooperation constitutes a unique and likely ancestral aspect of cellular protein homeostasis in which TF acts as an adaptor for ClpXP.","subitem_description_language":"en","subitem_description_type":"Abstract"}]},"item_10001_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Springer Nature","subitem_publisher_language":"en"}]},"item_10001_rights_15":{"attribute_name":"権利情報","attribute_value_mlt":[{"subitem_rights":"This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.","subitem_rights_language":"en"}]},"item_10001_source_id_9":{"attribute_name":"収録物ID","attribute_value_mlt":[{"subitem_source_identifier":"20411723","subitem_source_identifier_type":"ISSN"},{"subitem_source_identifier":"AA12645905","subitem_source_identifier_type":"NCID"}]},"item_10001_version_type_20":{"attribute_name":"出版タイプ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_1715043197608":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"open access"}]},"item_1722929371688":{"attribute_name":"出版社版DOI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_language":"ja","subitem_relation_name_text":"10.1038/s41467-020-20553-x"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://doi.org/10.1038/s41467-020-20553-x","subitem_relation_type_select":"DOI"}}]},"item_1723180141928":{"attribute_name":"EID","attribute_value_mlt":[{"subitem_identifier_type":"URI","subitem_identifier_uri":"381295"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Rizzolo, Kamran","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Yu, Angela Yeou Hsiung","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Ologbenla, Adedeji","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Kim, Sa Rang","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Zhu, Haojie","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"イシモリ, コウイチロウ","creatorNameLang":"ja"},{"creatorName":"イシモリ, コウイチロウ","creatorNameLang":"ja-Kana"},{"creatorName":"Ishimori, Koichiro","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Thibault, Guillaume","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Leung, Elisa","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Zhang, Yi Wen","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Teng, Mona","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Haniszewski, Marta","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Miah, Noha","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Phanse , Sadhna","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Minic, Zoran","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Lee, Sukyeong","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Caballero, Julio Diaz","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Babu, Mohan","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Tsai, Francis T. 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