{"created":"2024-12-12T01:56:07.814438+00:00","id":2009618,"links":{},"metadata":{"_buckets":{"deposit":"2a1af589-ec7c-446c-aee8-3d578a4346c4"},"_deposit":{"created_by":7,"id":"2009618","owners":[7],"pid":{"revision_id":0,"type":"depid","value":"2009618"},"status":"published"},"_oai":{"id":"oai:tokushima-u.repo.nii.ac.jp:02009618","sets":["1713853213384:1713853295607"]},"author_link":["489","328"],"control_number":"2009618","item_10001_alternative_title_1":{"attribute_name":"タイトル別表記","attribute_value_mlt":[{"subitem_alternative_title":"Computational Analysis of Dancing Cells","subitem_alternative_title_language":"en"}]},"item_10001_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2018-02-05","bibliographicIssueDateType":"Issued"},"bibliographicPageStart":"4","bibliographicVolumeNumber":"6","bibliographic_titles":[{"bibliographic_title":"Frontiers in Cell and Developmental Biology","bibliographic_titleLang":"en"}]}]},"item_10001_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Collective cell migration is observed during morphogenesis, angiogenesis, and wound healing, and this type of cell migration also contributes to efficient metastasis in some kinds of cancers. Because collectively migrating cells are much better organized than a random assemblage of individual cells, there seems to be a kind of order in migrating clusters. Extensive research has identified a large number of molecules involved in collective cell migration, and these factors have been analyzed using dramatic advances in imaging technology. To date, however, it remains unclear how myriad cells are integrated as a single unit. Recently, we observed unbalanced collective cell migrations that can be likened to either precision dancing or awa-odori, Japanese traditional dancing similar to the style at Rio Carnival, caused by the impairment of the conformational change of JRAB/MICAL-L2. This review begins with a brief history of image-based computational analyses on cell migration, explains why quantitative analysis of the stylization of collective cell behavior is difficult, and finally introduces our recent work on JRAB/MICAL-L2 as a successful example of the multidisciplinary approach combining cell biology, live imaging, and computational biology. In combination, these methods have enabled quantitative evaluations of the “dancing style” of collective cell migration.","subitem_description_language":"en","subitem_description_type":"Abstract"}]},"item_10001_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Frontiers Media S.A.","subitem_publisher_language":"en"}]},"item_10001_rights_15":{"attribute_name":"権利情報","attribute_value_mlt":[{"subitem_rights":"This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.","subitem_rights_language":"en"}]},"item_10001_source_id_9":{"attribute_name":"収録物ID","attribute_value_mlt":[{"subitem_source_identifier":"2296634X","subitem_source_identifier_type":"ISSN"}]},"item_10001_version_type_20":{"attribute_name":"出版タイプ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_1715043197608":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"open 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GTPases","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"JRAB/MICAL-L2","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"conformational change","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"collective cell migration","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"computational analysis","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"optical flow","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Dancing Styles of Collective Cell Migration : Image-Based Computational Analysis of 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