{"created":"2024-12-12T01:56:40.893976+00:00","id":2009625,"links":{},"metadata":{"_buckets":{"deposit":"4fd1373d-0833-4779-aaa5-c9bd5aa59681"},"_deposit":{"created_by":7,"id":"2009625","owners":[7],"pid":{"revision_id":0,"type":"depid","value":"2009625"},"status":"published"},"_oai":{"id":"oai:tokushima-u.repo.nii.ac.jp:02009625","sets":["1713853213384:1713853295607"]},"author_link":["756"],"control_number":"2009625","item_10001_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2021-12-13","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"12","bibliographicPageStart":"3513","bibliographicVolumeNumber":"10","bibliographic_titles":[{"bibliographic_title":"Cells","bibliographic_titleLang":"en"}]}]},"item_10001_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Interleukin (IL)-19, a member of the IL-10 family, is an anti-inflammatory cytokine produced primarily by macrophages. Nonalcoholic steatohepatitis (NASH) is a disease that has progressed from nonalcoholic fatty liver disease (NAFLD) and is characterized by inflammation and fibrosis. We evaluated the functions of IL-19 in a NAFLD/NASH mouse model using a 60% high fat diet with 0.1% methionine, without choline, and with 2% cholesterol (CDAHFD). Wild-type (WT) and IL-19 gene-deficient (KO) mice were fed a CDAHFD or standard diet for 9 weeks. Liver injury, inflammation, and fibrosis induced by CDAHFD were significantly worse in IL-19 KO mice than in WT mice. IL-6, TNF-α, and TGF-β were significantly higher in IL-19 KO mice than in WT mice. As a mechanism using an in vitro experiment, palmitate-induced triglyceride and cholesterol contents were decreased by the addition of IL-19 in HepG2 cells. Furthermore, addition of IL-19 decreased the expression of fatty acid synthesis-related enzymes and increased ATP content in HepG2 cells. The action of IL-19 in vitro suppressed lipid metabolism. In conclusion, IL-19 may play an important role in the development of steatosis and fibrosis by directly regulating liver metabolism and may be a potential target for the treatment of liver diseases.","subitem_description_language":"en","subitem_description_type":"Abstract"}]},"item_10001_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"MDPI","subitem_publisher_language":"en"}]},"item_10001_rights_15":{"attribute_name":"権利情報","attribute_value_mlt":[{"subitem_rights":"This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).","subitem_rights_language":"en"}]},"item_10001_source_id_9":{"attribute_name":"収録物ID","attribute_value_mlt":[{"subitem_source_identifier":"20734409","subitem_source_identifier_type":"ISSN"}]},"item_10001_version_type_20":{"attribute_name":"出版タイプ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_1715043197608":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"open 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タケシ","creatorNameLang":"ja"},{"creatorName":"イザワ, タケシ","creatorNameLang":"ja-Kana"},{"creatorName":"Izawa, Takeshi","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"ヒロタ, カナ","creatorNameLang":"ja"},{"creatorName":"ヒロタ, カナ","creatorNameLang":"ja-Kana"},{"creatorName":"Hirota, Kana","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"ニシヤマ, カズヒロ","creatorNameLang":"ja"},{"creatorName":"ニシヤマ, カズヒロ","creatorNameLang":"ja-Kana"},{"creatorName":"Nishiyama, Kazuhiro","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"イケガミ, アイリ","creatorNameLang":"ja"},{"creatorName":"イケガミ, アイリ","creatorNameLang":"ja-Kana"},{"creatorName":"Ikegami, Airi","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"アオヤマ, トモコ","creatorNameLang":"ja"},{"creatorName":"アオヤマ, トモコ","creatorNameLang":"ja-Kana"},{"creatorName":"Aoyama, Tomoko","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"イケ, ミキヒト","creatorNameLang":"ja"},{"creatorName":"イケ, 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コウイチ","creatorNameLang":"ja-Kana"},{"creatorName":"Tsuneyama, Koichi","creatorNameLang":"en"}],"familyNames":[{"familyName":"常山","familyNameLang":"ja"},{"familyName":"ツネヤマ","familyNameLang":"ja-Kana"},{"familyName":"Tsuneyama","familyNameLang":"en"}],"givenNames":[{"givenName":"幸一","givenNameLang":"ja"},{"givenName":"コウイチ","givenNameLang":"ja-Kana"},{"givenName":"Koichi","givenNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"756","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"289954/profile-ja.html","nameIdentifierScheme":"徳島大学 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