{"created":"2024-12-12T02:00:08.228423+00:00","id":2009669,"links":{},"metadata":{"_buckets":{"deposit":"a39b12c6-509b-4a4b-950f-39928b7295d4"},"_deposit":{"created_by":7,"id":"2009669","owners":[7],"pid":{"revision_id":0,"type":"depid","value":"2009669"},"status":"published"},"_oai":{"id":"oai:tokushima-u.repo.nii.ac.jp:02009669","sets":["1713853213384:1713853296295:1716267877313:1716268556148"]},"author_link":["1260","1445","1652"],"item_10001_alternative_title_1":{"attribute_name":"タイトル別表記","attribute_value_mlt":[{"subitem_alternative_title":"樹状細胞はニッケルアレルギーの発症時にニッケルイオンを抗原として直接認識する","subitem_alternative_title_language":"ja"}]},"item_10001_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2022-03-06","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"2","bibliographicPageEnd":"52","bibliographicPageStart":"40","bibliographicVolumeNumber":"34","bibliographic_titles":[{"bibliographic_title":"Journal of Oral Health and Biosciences","bibliographic_titleLang":"en"}]}]},"item_10001_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Metal hypersensitivity, a disorder of the immune system, typically manifests as contact hypersensitivity to metals during daily contact. The molecular mechanism whereby metals enter the body and cause allergic disorders remains elusive. It is thought that eluted metal ions are captured by dendritic cells (DCs) and transferred to the draining lymph nodes to activate T cells. Here, for the first time, we used a metal indicator Newport Green to locate the most common allergenic metal, nickel (Ni) ions, captured by DCs and transferred to lymph nodes. Capturing Ni ions did not affect the activity of DCs. Ni ions entered DCs and showed positive staining in keratinocytes. A time varied quantitative analysis demonstrated that at 1 h, a small amount of Ni ions was observed in the epidermal sheet. After 6 h, the number of Ni ions that entered the epidermal sheet reached a peak and remained constant for a few days and were gradually emitted 48 h later. In the cervical lymph nodes of mice, accumulation of Ni ions reached a peak within 24 h and then gradually decreased. The findings of this study will contribute to the development of effective diagnoses and treatment methods for patients allergic to Ni.","subitem_description_language":"en","subitem_description_type":"Abstract"}]},"item_10001_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"四国歯学会","subitem_publisher_language":"ja"}]},"item_10001_source_id_9":{"attribute_name":"収録物ID","attribute_value_mlt":[{"subitem_source_identifier":"21896682","subitem_source_identifier_type":"ISSN"}]},"item_10001_version_type_20":{"attribute_name":"出版タイプ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_be7fb7dd8ff6fe43","subitem_version_type":"NA"}]},"item_1714461018643":{"attribute_name":"報告番号","attribute_value_mlt":[{"subitem_dissertationnumber":"甲第3586号"}]},"item_1714461102074":{"attribute_name":"学位名","attribute_value_mlt":[{"subitem_degreename":"博士（歯学）","subitem_degreename_language":"ja"}]},"item_1714461118377":{"attribute_name":"学位授与年月日","attribute_value_mlt":[{"subitem_dategranted":"2022-03-10"}]},"item_1714461137393":{"attribute_name":"学位授与機関","attribute_value_mlt":[{"subitem_degreegrantor":[{"subitem_degreegrantor_language":"ja","subitem_degreegrantor_name":"徳島大学"}]}]},"item_1715043197608":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"open access"}]},"item_1718868208704":{"attribute_name":"備考","attribute_value_mlt":[{"subitem_textarea_language":"ja","subitem_textarea_value":"内容要旨・審査要旨・論文本文の公開\n本論文は，著者Lipei Liuの学位論文として提出され，学位審査・授与の対象となっている。\n学位授与者所属 : 徳島大学大学院口腔科学教育部（口腔科学専攻）"}]},"item_1718868303842":{"attribute_name":"学位記番号","attribute_value_mlt":[{"subitem_text_language":"ja","subitem_text_value":"甲口第481号"}]},"item_1722929371688":{"attribute_name":"出版社版DOI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_language":"ja","subitem_relation_name_text":"10.20738/johb.34.2_40"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://doi.org/10.20738/johb.34.2_40","subitem_relation_type_select":"DOI"}}]},"item_1723180141928":{"attribute_name":"EID","attribute_value_mlt":[{"subitem_identifier_type":"URI","subitem_identifier_uri":"387596"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"リュウ, レイハイ","creatorNameLang":"ja"},{"creatorName":"リュウ, レイハイ","creatorNameLang":"ja-Kana"},{"creatorName":"Liu, Lipei","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"渡邉, 恵","creatorNameLang":"ja"}],"nameIdentifiers":[{"nameIdentifier":"1260","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"南, 憲一","creatorNameLang":"ja"}],"nameIdentifiers":[{"nameIdentifier":"1445","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Yunizar, Mohammad Fadyl","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"市川, 哲雄","creatorNameLang":"ja"}],"nameIdentifiers":[{"nameIdentifier":"1652","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_access","date":[{"dateType":"Available","dateValue":"2022-04-26"}],"displaytype":"detail","filename":"k3586_abstract.pdf","filesize":[{"value":"103 KB"}],"format":"application/pdf","mimetype":"application/pdf","url":{"objectType":"abstract","url":"https://tokushima-u.repo.nii.ac.jp/record/2009669/files/k3586_abstract.pdf"},"version_id":"88ce9bf9-ff8d-467f-8245-8f6cf4fb0144"},{"accessrole":"open_access","date":[{"dateType":"Available","dateValue":"2022-04-26"}],"displaytype":"detail","filename":"k3586_review.pdf","filesize":[{"value":"58.5 KB"}],"format":"application/pdf","mimetype":"application/pdf","url":{"objectType":"other","url":"https://tokushima-u.repo.nii.ac.jp/record/2009669/files/k3586_review.pdf"},"version_id":"205c9eaf-9833-47c3-8037-b54767de72d3"},{"accessrole":"open_access","date":[{"dateType":"Available","dateValue":"2022-04-26"}],"displaytype":"detail","filename":"k3586_fulltext.pdf","filesize":[{"value":"11.5 MB"}],"format":"application/pdf","mimetype":"application/pdf","url":{"objectType":"fulltext","url":"https://tokushima-u.repo.nii.ac.jp/record/2009669/files/k3586_fulltext.pdf"},"version_id":"27b7d575-beb8-4ad6-a7cf-5faabf498b15"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"Metal allergy","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Nickel ions","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Phagocytosis","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Dendritic cell migration","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"doctoral thesis","resourceuri":"http://purl.org/coar/resource_type/c_db06"}]},"item_title":"Dendritic Cells Directly Recognize Nickel Ions as an Antigen during the Development of Nickel Allergy","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Dendritic Cells Directly Recognize Nickel Ions as an Antigen during the Development of Nickel Allergy","subitem_title_language":"en"}]},"item_type_id":"40001","owner":"7","path":["1716268556148"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2022-03-10"},"publish_date":"2022-03-10","publish_status":"0","recid":"2009669","relation_version_is_last":true,"title":["Dendritic Cells Directly Recognize Nickel Ions as an Antigen during the Development of Nickel Allergy"],"weko_creator_id":"7","weko_shared_id":-1},"updated":"2024-12-12T02:00:17.905695+00:00"}