{"created":"2024-12-12T02:07:20.919746+00:00","id":2009767,"links":{},"metadata":{"_buckets":{"deposit":"05d20a14-7fd2-40d8-891f-b4d27c791591"},"_deposit":{"created_by":7,"id":"2009767","owners":[7],"pid":{"revision_id":0,"type":"depid","value":"2009767"},"status":"published"},"_oai":{"id":"oai:tokushima-u.repo.nii.ac.jp:02009767","sets":["1713853213384:1713853296295:1716267876683:1716268551628"]},"author_link":["396","1192","424","1214","1540","526","1633","1000","1622","1623"],"item_10001_alternative_title_1":{"attribute_name":"タイトル別表記","attribute_value_mlt":[{"subitem_alternative_title":"疾患活動性の高い重症筋無力症患者の胸腺ではプラズマブラストが増加している","subitem_alternative_title_language":"ja"}]},"item_10001_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2021-09-24","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"6","bibliographicPageStart":"e1087","bibliographicVolumeNumber":"8","bibliographic_titles":[{"bibliographic_title":"Neurology : Neuroimmunology & Neuroinflammation","bibliographic_titleLang":"en"}]}]},"item_10001_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Background and Objectives\nTo investigate intrathymic B lymphopoiesis in patients with myasthenia gravis (MG) and explore thymus pathology associated with clinical impact.\nMethods\nThymic lymphocytes from 15 young patients without MG, 22 adult patients without MG, 14 patients with MG without thymoma, and 11 patients with MG with thymoma were subjected to flow cytometry analysis of T follicular helper (Tfh), naive B, memory B, plasmablasts, CD19+B220high thymic B cells, B-cell activating factor receptor, and C-X-C chemokine receptor 5 (CXCR5). Peripheral blood mononuclear cells of 16 healthy subjects and 21 untreated patients with MG were also analyzed. Immunologic values were compared, and correlations between relevant values and clinical parameters were evaluated.\nResults\nThe frequencies of circulating and intrathymic plasmablasts were significantly higher in patients with MG than controls. On the other hand, the frequency of CD19+B220high thymic B cells was not increased in MG thymus. We observed a significant increase in CXCR5 expression on plasmablasts in MG thymus and an increased frequency of intrathymic plasmablasts that was correlated with preoperative disease activity. The frequency of intrathymic Tfh cells was significantly lower in patients who received immunosuppressive (IS) therapy than those without IS therapy. However, there was no significant difference in the frequency of intrathymic plasmablasts irrespective of IS therapy.\nDiscussion\nOur findings confirmed a correlation between increased frequency of intrathymic plasmablasts and disease activity before thymectomy. We postulate that activated intrathymic plasmablasts endow pathogenic capacity in MG.","subitem_description_language":"en","subitem_description_type":"Abstract"}]},"item_10001_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Wolters Kluwer","subitem_publisher_language":"en"},{"subitem_publisher":"American Academy of Neurology","subitem_publisher_language":"en"}]},"item_10001_rights_15":{"attribute_name":"権利情報","attribute_value_mlt":[{"subitem_rights":"This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivatives License 4.0 (CC BY-NC-ND), which permits downloading and sharing the work provided it is properly cited ( https://creativecommons.org/licenses/by-nc-nd/4.0/ ). The work cannot be changed in any way or used commercially without permission from the journal.","subitem_rights_language":"en"}]},"item_10001_source_id_9":{"attribute_name":"収録物ID","attribute_value_mlt":[{"subitem_source_identifier":"23327812","subitem_source_identifier_type":"ISSN"},{"subitem_source_identifier":"AA12724386","subitem_source_identifier_type":"NCID"}]},"item_10001_version_type_20":{"attribute_name":"出版タイプ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_be7fb7dd8ff6fe43","subitem_version_type":"NA"}]},"item_1714461018643":{"attribute_name":"報告番号","attribute_value_mlt":[{"subitem_dissertationnumber":"甲第3581号"}]},"item_1714461102074":{"attribute_name":"学位名","attribute_value_mlt":[{"subitem_degreename":"博士（医学）","subitem_degreename_language":"ja"}]},"item_1714461118377":{"attribute_name":"学位授与年月日","attribute_value_mlt":[{"subitem_dategranted":"2022-03-04"}]},"item_1714461137393":{"attribute_name":"学位授与機関","attribute_value_mlt":[{"subitem_degreegrantor":[{"subitem_degreegrantor_language":"ja","subitem_degreegrantor_name":"徳島大学"}]}]},"item_1715043197608":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"open access"}]},"item_1718868208704":{"attribute_name":"備考","attribute_value_mlt":[{"subitem_textarea_language":"ja","subitem_textarea_value":"内容要旨・審査要旨・論文本文の公開\n本論文は，著者Yohei Yamamotoの学位論文として提出され，学位審査・授与の対象となっている。\n学位授与者所属 : 徳島大学大学院医科学教育部（医学専攻）"}]},"item_1718868303842":{"attribute_name":"学位記番号","attribute_value_mlt":[{"subitem_text_language":"ja","subitem_text_value":"甲医第1526号"}]},"item_1722929371688":{"attribute_name":"出版社版DOI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_language":"ja","subitem_relation_name_text":"10.1212/NXI.0000000000001087"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://doi.org/10.1212/NXI.0000000000001087","subitem_relation_type_select":"DOI"}}]},"item_1723180141928":{"attribute_name":"EID","attribute_value_mlt":[{"subitem_identifier_type":"URI","subitem_identifier_uri":"384892"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"山本, 遥平","creatorNameLang":"ja"},{"creatorName":"ヤマモト, ヨウヘイ","creatorNameLang":"ja-Kana"},{"creatorName":"Yamamoto, Yohei","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"松井, 尚子","creatorNameLang":"ja"}],"nameIdentifiers":[{"nameIdentifier":"396","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"ウザワ, アキユキ","creatorNameLang":"ja"},{"creatorName":"ウザワ, アキユキ","creatorNameLang":"ja-Kana"},{"creatorName":"Uzawa, Akiyuki","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"オザワ, ユキコ","creatorNameLang":"ja"},{"creatorName":"オザワ, ユキコ","creatorNameLang":"ja-Kana"},{"creatorName":"Ozawa, Yukiko","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"カナイ, テツヤ","creatorNameLang":"ja"},{"creatorName":"カナイ, テツヤ","creatorNameLang":"ja-Kana"},{"creatorName":"Kanai, Tetsuya","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"オダ, フミコ","creatorNameLang":"ja"},{"creatorName":"オダ, フミコ","creatorNameLang":"ja-Kana"},{"creatorName":"Oda, Fumiko","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"近藤, 博之","creatorNameLang":"ja"}],"nameIdentifiers":[{"nameIdentifier":"1192","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"大東, いずみ","creatorNameLang":"ja"}],"nameIdentifiers":[{"nameIdentifier":"424","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"滝沢, 宏光","creatorNameLang":"ja"}],"nameIdentifiers":[{"nameIdentifier":"1214","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"近藤, 和也","creatorNameLang":"ja"}],"nameIdentifiers":[{"nameIdentifier":"1540","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"菅野, 幹雄","creatorNameLang":"ja"}],"nameIdentifiers":[{"nameIdentifier":"526","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"北市, 隆","creatorNameLang":"ja"}],"nameIdentifiers":[{"nameIdentifier":"1633","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"秦, 広樹","creatorNameLang":"ja"}],"nameIdentifiers":[{"nameIdentifier":"1000","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"梶, 龍兒","creatorNameLang":"ja"}],"nameIdentifiers":[{"nameIdentifier":"1622","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"クワバラ, サトシ","creatorNameLang":"ja"},{"creatorName":"クワバラ, サトシ","creatorNameLang":"ja-Kana"},{"creatorName":"Kuwabara, Satoshi","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"ヤマムラ, タカシ","creatorNameLang":"ja"},{"creatorName":"ヤマムラ, タカシ","creatorNameLang":"ja-Kana"},{"creatorName":"Yamamura, Takashi","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"和泉, 唯信","creatorNameLang":"ja"}],"nameIdentifiers":[{"nameIdentifier":"1623","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_access","date":[{"dateType":"Available","dateValue":"2022-05-19"}],"displaytype":"detail","filename":"k3581_abstract_review.pdf","filesize":[{"value":"176 KB"}],"format":"application/pdf","mimetype":"application/pdf","url":{"objectType":"abstract","url":"https://tokushima-u.repo.nii.ac.jp/record/2009767/files/k3581_abstract_review.pdf"},"version_id":"fed63003-7c91-4fc8-95f5-6380fb21292f"},{"accessrole":"open_access","date":[{"dateType":"Available","dateValue":"2022-05-19"}],"displaytype":"detail","filename":"k3581_fulltext.pdf","filesize":[{"value":"846 KB"}],"format":"application/pdf","mimetype":"application/pdf","url":{"objectType":"fulltext","url":"https://tokushima-u.repo.nii.ac.jp/record/2009767/files/k3581_fulltext.pdf"},"version_id":"c15ca09f-9f6b-47e0-82bc-9efb4d241af7"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"Myasthenia Gravis","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Thymectomy","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Plasmablast","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"B cell","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Tfh cell","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"doctoral thesis","resourceuri":"http://purl.org/coar/resource_type/c_db06"}]},"item_title":"Intrathymic Plasmablasts Are Affected in Patients With Myasthenia Gravis With Active Disease","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Intrathymic Plasmablasts Are Affected in Patients With Myasthenia Gravis With Active Disease","subitem_title_language":"en"}]},"item_type_id":"40001","owner":"7","path":["1716268551628"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2022-05-19"},"publish_date":"2022-05-19","publish_status":"0","recid":"2009767","relation_version_is_last":true,"title":["Intrathymic Plasmablasts Are Affected in Patients With Myasthenia Gravis With Active Disease"],"weko_creator_id":"7","weko_shared_id":-1},"updated":"2024-12-12T02:07:29.571843+00:00"}