{"created":"2024-12-12T02:07:39.904326+00:00","id":2009771,"links":{},"metadata":{"_buckets":{"deposit":"72cf8183-1397-4cb3-860b-6a85b0f9accc"},"_deposit":{"created_by":7,"id":"2009771","owners":[7],"pid":{"revision_id":0,"type":"depid","value":"2009771"},"status":"published"},"_oai":{"id":"oai:tokushima-u.repo.nii.ac.jp:02009771","sets":["1713853213384:1713853296295:1716267876683:1716268551628"]},"author_link":["639","270","431","1265","884","1536"],"item_10001_alternative_title_1":{"attribute_name":"タイトル別表記","attribute_value_mlt":[{"subitem_alternative_title":"ベタヒスチンが一側内耳破壊後のラットの前庭代償に与える影響","subitem_alternative_title_language":"ja"}]},"item_10001_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2021-03-11","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"3","bibliographicPageStart":"360","bibliographicVolumeNumber":"11","bibliographic_titles":[{"bibliographic_title":"Brain Sciences","bibliographic_titleLang":"en"}]}]},"item_10001_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Background: Vestibular compensation (VC) after unilateral labyrinthectomy (UL) consists of the initial and late processes. These processes can be evaluated based on the decline in the frequency of spontaneous nystagmus (SN) and the number of MK801-induced Fos-positive neurons in the contralateral medial vestibular nucleus (contra-MVe) in rats. Histamine H3 receptors (H3R) are reported to be involved in the development of VC. Objective: We examined the effects of betahistine, an H3R antagonist, on the initial and late processes of VC in UL rats. Methods: Betahistine dihydrochloride was continuously administered to the UL rats at doses of 100 and 200 mg/kg/day using an osmotic minipump. MK801 (1.0 mg/kg) was intraperitoneally administered on days 7, 10, 12, and 14 after UL, while Fos-positive neurons were immunohistochemically stained in the contra-MVe. Results: The SN disappeared after 42 h, and continuous infusion of betahistine did not change the decline in the frequency of SN. The number of MK801-induced Fos-positive neurons in contra-MVe significantly decreased on days 7, 10, and 12 after UL in a dose-dependent manner in the betahistine-treated rats, more so than in the saline-treated rats. Conclusion: These findings suggest that betahistine facilitated the late, but not the initial, process of VC in UL rats.","subitem_description_language":"en","subitem_description_type":"Abstract"}]},"item_10001_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"MDPI","subitem_publisher_language":"en"}]},"item_10001_rights_15":{"attribute_name":"権利情報","attribute_value_mlt":[{"subitem_rights":"© 2021 by the authors. Licensee MDPI, Basel, Switzerland.\nThis article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license ( https://creativecommons.org/licenses/by/4.0/ ).","subitem_rights_language":"en"}]},"item_10001_source_id_9":{"attribute_name":"収録物ID","attribute_value_mlt":[{"subitem_source_identifier":"20763425","subitem_source_identifier_type":"ISSN"}]},"item_10001_version_type_20":{"attribute_name":"出版タイプ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_be7fb7dd8ff6fe43","subitem_version_type":"NA"}]},"item_1714461018643":{"attribute_name":"報告番号","attribute_value_mlt":[{"subitem_dissertationnumber":"甲第3591号"}]},"item_1714461102074":{"attribute_name":"学位名","attribute_value_mlt":[{"subitem_degreename":"博士（医学）","subitem_degreename_language":"ja"}]},"item_1714461118377":{"attribute_name":"学位授与年月日","attribute_value_mlt":[{"subitem_dategranted":"2022-03-23"}]},"item_1714461137393":{"attribute_name":"学位授与機関","attribute_value_mlt":[{"subitem_degreegrantor":[{"subitem_degreegrantor_language":"ja","subitem_degreegrantor_name":"徳島大学"}]}]},"item_1715043197608":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"open access"}]},"item_1718868208704":{"attribute_name":"備考","attribute_value_mlt":[{"subitem_textarea_language":"ja","subitem_textarea_value":"内容要旨・審査要旨・論文本文の公開\n 本論文は，著者Junya Fukudaの学位論文として提出され，学位審査・授与の対象となっている。\n学位授与者所属 : 徳島大学大学院医科学教育部（医学専攻）"}]},"item_1718868303842":{"attribute_name":"学位記番号","attribute_value_mlt":[{"subitem_text_language":"ja","subitem_text_value":"甲医第1519号"}]},"item_1722929371688":{"attribute_name":"出版社版DOI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_language":"ja","subitem_relation_name_text":"10.3390/brainsci11030360"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://doi.org/10.3390/brainsci11030360","subitem_relation_type_select":"DOI"}}]},"item_1723180141928":{"attribute_name":"EID","attribute_value_mlt":[{"subitem_identifier_type":"URI","subitem_identifier_uri":"385405"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"福田, 潤弥","creatorNameLang":"ja"},{"creatorName":"フクダ, ジュンヤ","creatorNameLang":"ja-Kana"},{"creatorName":"Fukuda, Junya","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"松田, 和徳","creatorNameLang":"ja"}],"nameIdentifiers":[{"nameIdentifier":"639","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"佐藤, 豪","creatorNameLang":"ja"}],"nameIdentifiers":[{"nameIdentifier":"270","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"キタハラ, タダシ","creatorNameLang":"ja"},{"creatorName":"キタハラ, タダシ","creatorNameLang":"ja-Kana"},{"creatorName":"Kitahara, Tadashi","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"マツオカ, モモヨ","creatorNameLang":"ja"},{"creatorName":"マツオカ, モモヨ","creatorNameLang":"ja-Kana"},{"creatorName":"Matsuoka, Momoyo","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"東, 貴弘","creatorNameLang":"ja"}],"nameIdentifiers":[{"nameIdentifier":"431","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"北村, 嘉章","creatorNameLang":"ja"}],"nameIdentifiers":[{"nameIdentifier":"1265","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"冨田, 江一","creatorNameLang":"ja"}],"nameIdentifiers":[{"nameIdentifier":"884","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"武田, 憲昭","creatorNameLang":"ja"}],"nameIdentifiers":[{"nameIdentifier":"1536","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_access","date":[{"dateType":"Available","dateValue":"2022-05-25"}],"displaytype":"detail","filename":"k3591_abstract_review.pdf","filesize":[{"value":"194 KB"}],"format":"application/pdf","mimetype":"application/pdf","url":{"objectType":"abstract","url":"https://tokushima-u.repo.nii.ac.jp/record/2009771/files/k3591_abstract_review.pdf"},"version_id":"7b51b10d-ff23-4ec2-ba67-923d75b3dc8f"},{"accessrole":"open_access","date":[{"dateType":"Available","dateValue":"2022-05-25"}],"displaytype":"detail","filename":"k3591_fulltext.pdf","filesize":[{"value":"1.14 MB"}],"format":"application/pdf","mimetype":"application/pdf","url":{"objectType":"fulltext","url":"https://tokushima-u.repo.nii.ac.jp/record/2009771/files/k3591_fulltext.pdf"},"version_id":"ad643d1e-47f4-4c51-acdc-8447d147a7eb"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"vestibular compensation","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"betahistine dihydrochloride","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"medial vestibular nucleus","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Fos","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"histamine H3 receptor","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"doctoral thesis","resourceuri":"http://purl.org/coar/resource_type/c_db06"}]},"item_title":"Effects of Betahistine on the Development of Vestibular Compensation after Unilateral Labyrinthectomy in Rats","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Effects of Betahistine on the Development of Vestibular Compensation after Unilateral Labyrinthectomy in Rats","subitem_title_language":"en"}]},"item_type_id":"40001","owner":"7","path":["1716268551628"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2022-05-25"},"publish_date":"2022-05-25","publish_status":"0","recid":"2009771","relation_version_is_last":true,"title":["Effects of Betahistine on the Development of Vestibular Compensation after Unilateral Labyrinthectomy in Rats"],"weko_creator_id":"7","weko_shared_id":-1},"updated":"2024-12-12T02:07:49.382335+00:00"}