{"created":"2024-12-12T02:07:49.937555+00:00","id":2009773,"links":{},"metadata":{"_buckets":{"deposit":"96b43d4d-da9e-4bd7-b633-d58e381756fc"},"_deposit":{"created_by":7,"id":"2009773","owners":[7],"pid":{"revision_id":0,"type":"depid","value":"2009773"},"status":"published"},"_oai":{"id":"oai:tokushima-u.repo.nii.ac.jp:02009773","sets":["1713853213384:1713853296295:1716267876683:1716268551628"]},"author_link":["970","454","930","1645","343"],"item_10001_alternative_title_1":{"attribute_name":"タイトル別表記","attribute_value_mlt":[{"subitem_alternative_title":"術後嘔気・嘔吐に対するNK-1受容体拮抗薬 : システマティックレビューとメタ解析","subitem_alternative_title_language":"ja"},{"subitem_alternative_title":"Antagonistas do receptor da neurocinina-1 no tratamento de náusea e vômito no pós-operatório : revisão sistemática e meta-análise","subitem_alternative_title_language":"en"}]},"item_10001_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2020-06-25","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"5","bibliographicPageEnd":"519","bibliographicPageStart":"508","bibliographicVolumeNumber":"70","bibliographic_titles":[{"bibliographic_title":"Brazilian Journal of Anesthesiology (English Edition)","bibliographic_titleLang":"en"}]}]},"item_10001_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Background: Postoperative Nausea and Vomiting (PONV) is a common complication of general anesthesia. Several kinds of antiemetics, including 5-Hydroxytryptamine3 (5-HT3) receptor antagonists, and Neurokinin-1 (NK-1) receptor antagonists have been used to treat PONV.\nObjectives: To compare the antiemetic effect of NK-1 receptor antagonists, including fosaprepitant.\nData sources: Online databases (PubMed, MEDLINE, Scopus, The Cochrane Library databases) were used.\nStudy eligibility criteria, participants, and interventions: Randomized Controlled Trials (RCTs) performed in patients over 18 years with ASA-PS of I-III, aimed to assess the efficacy of antiemetics including NK-1 receptor antagonists and 5-HT3 receptor antagonists, and compared the incidence of PONV were included.\nStudy appraisal and synthesis methods: All statistical assessments were conducted by a random effect approach, and odds ratios and 95% Confidence Intervals were calculated.\nResults: Aprepitant 40 mg and 80 mg significantly reduced the incidence of vomiting 0-24 hours postoperatively (Odds Ratio [OR = 0.40]; 95% Confidence Interval [95% CI 0.30-0.54]; p < 0.001, and OR = 0.32; 95% CI 0.19-0.56; p < 0.001). Fosaprepitant could also reduce the incidence of vomiting significantly both 0-24 and 0-48 hours postoperatively (OR = 0.07; 95% CI 0.02-0.24; p < 0.001 and OR = 0.07; 95% CI 0.02-0.23; p < 0.001).\nLimitations: Risk factors for PONV are not considered, RCTs using multiple antiemetics are included, RCTs for fosaprepitant is small, and some bias may be present.\nConclusions and implications of key findings: Aprepitant and fosaprepitant can be effective prophylactic antiemetics for postoperative vomiting. However, more studies are required for higher-quality meta-analyses.","subitem_description_language":"en","subitem_description_type":"Abstract"},{"subitem_description":"Histórico: Náusea e Vômito no Pós-Operatório (NVPO) é um evento adverso frequente da anestesia geral. Várias classes de antieméticos, incluindo antagonistas do receptor 5-Hidroxitriptamina3 (5-HT3) e antagonistas do receptor da Neurocinina-1 (NK-1), têm sido utilizados para tratar a NVPO.\nObjetivo: Comparar o efeito antiemético dos antagonistas do receptor NK-1, incluindo o fosaprepitanto.\nFontes de dados: Foram utilizadas bases de dados on-line (PubMed, MEDLINE, Scopus, The Cochrane Library).\nCritérios de elegibilidade do estudo, participantes e intervenções: Foram incluídos Estudos Clínicos Randomizados (ECR) realizados em pacientes acima de 18 anos classificação ASA I a III, com o objetivo de avaliar a eficácia de antieméticos que incluíssem antagonistas do receptor NK-1 e antagonistas do receptor 5-HT3, e que comparassem a incidência de NVPO.\nMétodos de avaliação e síntese do estudo: Todas as avaliações estatísticas foram realizadas por abordagem de efeito aleatório e foram calculadas razões de chances e Intervalos de Confiança de 95%.\nResultados: As doses de 40 mg e 80 mg de aprepitanto reduziram significantemente a incidência de vômito no período de 0 a 24 horas pós-operatórias (razão de chances [OR = 0,40]; Intervalo de Confiança de 95% [95% IC] 0,30-0,54; p < 0,001 e OR = 0,32; 95% IC 0,19-0,56; p < 0,001). O fosaprepitanto pode também reduzir significantemente a incidência de vômito tanto de 0-24 horas como no período de 0-48 horas pós-operatórias (OR = 0,07; 95% IC 0,02-0,24; p < 0,001 e OR = 0,07; 95% IC 0,02-0,23; p < 0,001).\nLimitações:Os fatores de risco para NVPO não foram analisados, ECRs usando múltiplos antieméticos foram incluídos, ECRs para fosaprepitanto tinham amostras pequenas, podendo haver algum viés.\nConclusões e implicações dos principais achados: Aprepitanto e fosaprepitanto podem ser drogas antieméticas profiláticas efetivas para vômito no pós-operatório. No entanto, são necessários mais estudos para a elaboração de meta-análises de melhor qualidade.","subitem_description_language":"en","subitem_description_type":"Abstract"}]},"item_10001_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Sociedade Brasileira de Anestesiologia","subitem_publisher_language":"en"},{"subitem_publisher":"Elsevier","subitem_publisher_language":"en"}]},"item_10001_rights_15":{"attribute_name":"権利情報","attribute_value_mlt":[{"subitem_rights":"This is an open access article under the CC BY-NC-ND license ( http://creativecommons.org/licenses/by-nc-nd/4.0/ ).","subitem_rights_language":"en"}]},"item_10001_source_id_9":{"attribute_name":"収録物ID","attribute_value_mlt":[{"subitem_source_identifier":"01040014","subitem_source_identifier_type":"ISSN"}]},"item_10001_version_type_20":{"attribute_name":"出版タイプ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_be7fb7dd8ff6fe43","subitem_version_type":"NA"}]},"item_1714461018643":{"attribute_name":"報告番号","attribute_value_mlt":[{"subitem_dissertationnumber":"甲第3593号"}]},"item_1714461102074":{"attribute_name":"学位名","attribute_value_mlt":[{"subitem_degreename":"博士（医学）","subitem_degreename_language":"ja"}]},"item_1714461118377":{"attribute_name":"学位授与年月日","attribute_value_mlt":[{"subitem_dategranted":"2022-03-23"}]},"item_1714461137393":{"attribute_name":"学位授与機関","attribute_value_mlt":[{"subitem_degreegrantor":[{"subitem_degreegrantor_language":"ja","subitem_degreegrantor_name":"徳島大学"}]}]},"item_1715043197608":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"open access"}]},"item_1718868208704":{"attribute_name":"備考","attribute_value_mlt":[{"subitem_textarea_language":"ja","subitem_textarea_value":"内容要旨・審査要旨・論文本文の公開\n本論文は，著者Chiaki Murakamiの学位論文として提出され，学位審査・授与の対象となっている。\nポルトガル語版論文あり（DOI：https://doi.org/10.1016/j.bjan.2020.04.005）\n学位授与者所属 : 徳島大学大学院医科学教育部（医学専攻）"}]},"item_1718868303842":{"attribute_name":"学位記番号","attribute_value_mlt":[{"subitem_text_language":"ja","subitem_text_value":"甲医第1522号"}]},"item_1722929371688":{"attribute_name":"出版社版DOI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_language":"ja","subitem_relation_name_text":"10.1016/j.bjane.2020.06.015"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://doi.org/10.1016/j.bjane.2020.06.015","subitem_relation_type_select":"DOI"}}]},"item_1723180141928":{"attribute_name":"EID","attribute_value_mlt":[{"subitem_identifier_type":"URI","subitem_identifier_uri":"381837"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"村上, 千晶","creatorNameLang":"ja"}],"nameIdentifiers":[{"nameIdentifier":"970","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"角田, 奈美","creatorNameLang":"ja"}],"nameIdentifiers":[{"nameIdentifier":"454","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"里見, 志帆","creatorNameLang":"ja"}],"nameIdentifiers":[{"nameIdentifier":"930","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"ナカムラ, リュウジ","creatorNameLang":"ja"},{"creatorName":"ナカムラ, リュウジ","creatorNameLang":"ja-Kana"},{"creatorName":"Nakamura, Ryuji","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"ミヨシ, ヒロツグ","creatorNameLang":"ja"},{"creatorName":"ミヨシ, ヒロツグ","creatorNameLang":"ja-Kana"},{"creatorName":"Miyoshi, Hirotsugu","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"モリオ, アツシ","creatorNameLang":"ja"},{"creatorName":"モリオ, アツシ","creatorNameLang":"ja-Kana"},{"creatorName":"Morio, Atsushi","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"サエキ, ノボル","creatorNameLang":"ja"},{"creatorName":"サエキ, ノボル","creatorNameLang":"ja-Kana"},{"creatorName":"Saeki, Noboru","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"カトウ, タカヒロ","creatorNameLang":"ja"},{"creatorName":"カトウ, タカヒロ","creatorNameLang":"ja-Kana"},{"creatorName":"Kato, Takahiro","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"オオシタ, ナオヒロ","creatorNameLang":"ja"},{"creatorName":"オオシタ, ナオヒロ","creatorNameLang":"ja-Kana"},{"creatorName":"Ohshita, Naohiro","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"田中, 克哉","creatorNameLang":"ja"}],"nameIdentifiers":[{"nameIdentifier":"1645","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"堤, 保夫","creatorNameLang":"ja"}],"nameIdentifiers":[{"nameIdentifier":"343","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_access","date":[{"dateType":"Available","dateValue":"2022-05-25"}],"displaytype":"detail","filename":"k3593_abstract_review.pdf","filesize":[{"value":"269 KB"}],"format":"application/pdf","mimetype":"application/pdf","url":{"objectType":"abstract","url":"https://tokushima-u.repo.nii.ac.jp/record/2009773/files/k3593_abstract_review.pdf"},"version_id":"f6c28c5b-74cf-4d91-a1d5-fd9f9d3e22fe"},{"accessrole":"open_access","date":[{"dateType":"Available","dateValue":"2022-05-25"}],"displaytype":"detail","filename":"k3593_fulltext.pdf","filesize":[{"value":"1.21 MB"}],"format":"application/pdf","mimetype":"application/pdf","url":{"objectType":"fulltext","url":"https://tokushima-u.repo.nii.ac.jp/record/2009773/files/k3593_fulltext.pdf"},"version_id":"83f9afdf-080c-4c78-8a6c-ab843834c52d"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"postoperative nausea and vomiting","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"prophylaxis","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"treatment","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"NK-1 receptor antagonists","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Náusea e vômito no pós-operatório","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Profilaxia","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Tratamento","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Antagonistas do receptor NK-1","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"doctoral thesis","resourceuri":"http://purl.org/coar/resource_type/c_db06"}]},"item_title":"Neurokinin-1 receptor antagonists for postoperative nausea and vomiting : a systematic review and meta-analysis","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Neurokinin-1 receptor antagonists for postoperative nausea and vomiting : a systematic review and meta-analysis","subitem_title_language":"en"}]},"item_type_id":"40001","owner":"7","path":["1716268551628"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2022-05-25"},"publish_date":"2022-05-25","publish_status":"0","recid":"2009773","relation_version_is_last":true,"title":["Neurokinin-1 receptor antagonists for postoperative nausea and vomiting : a systematic review and meta-analysis"],"weko_creator_id":"7","weko_shared_id":-1},"updated":"2024-12-12T02:08:03.489096+00:00"}